STK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0035265Biological processorgan growth
GO_0030216Biological processkeratinocyte differentiation
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0001841Biological processneural tube formation
GO_0035329Biological processhippo signaling
GO_0032092Biological processpositive regulation of protein binding
GO_0007165Biological processsignal transduction
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_1903945Biological processpositive regulation of hepatocyte apoptotic process
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_1902043Biological processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0046621Biological processnegative regulation of organ growth
GO_0003157Biological processendocardium development
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_1904237Biological processpositive regulation of substrate-dependent cell migration, cell attachment to substrate
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0051262Biological processprotein tetramerization
GO_0001569Biological processbranching involved in blood vessel morphogenesis
GO_0035556Biological processintracellular signal transduction
GO_0050821Biological processprotein stabilization
GO_0097284Biological processhepatocyte apoptotic process
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0006606Biological processprotein import into nucleus
GO_0007417Biological processcentral nervous system development
GO_0060706Biological processcell differentiation involved in embryonic placenta development
GO_0006915Biological processapoptotic process
GO_0060800Biological processregulation of cell differentiation involved in embryonic placenta development
GO_0000902Biological processcell morphogenesis
GO_0006468Biological processprotein phosphorylation
GO_0043408Biological processregulation of MAPK cascade
GO_0046777Biological processprotein autophosphorylation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0060215Biological processprimitive hemopoiesis
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTK4
Protein nameSerine/threonine kinase 4
Serine/threonine-protein kinase 4 (EC 2.7.11.1)
Serine/threonine-protein kinase 4
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]
SynonymsMST1
KRS2
DescriptionFUNCTION: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. .

AccessionsF5H5B4
ENST00000372801.5 [Q13043-2]
ENST00000474717.3
A0A087WVN8
ENST00000698220.1
ENST00000487587.3
ENST00000372806.8 [Q13043-1]
Q13043
ENST00000698224.1
A0A087WYT4
ENST00000698219.1
ENST00000499879.7
A0A8V8TLH7
ENST00000698218.1
A0A8V8TNA0
A0A8V8TLK1
ENST00000698222.1
A0PJ51
ENST00000698221.1
A0A8V8TM18
A0A8V8TM13
A0A8V8TN08