PIK3R1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	40% ± 16%	Explore
fibroblast	34 studies	36% ± 15%	Explore
CD8-positive, alpha-beta T cell	32 studies	34% ± 11%	Explore
T cell	28 studies	31% ± 12%	Explore
macrophage	28 studies	32% ± 16%	Explore
CD4-positive, alpha-beta T cell	25 studies	34% ± 11%	Explore
mature NK T cell	21 studies	37% ± 11%	Explore
regulatory T cell	21 studies	32% ± 12%	Explore
astrocyte	20 studies	39% ± 14%	Explore
mast cell	18 studies	29% ± 9%	Explore
endothelial cell	18 studies	29% ± 12%	Explore
pericyte	17 studies	31% ± 14%	Explore
smooth muscle cell	17 studies	28% ± 10%	Explore
gamma-delta T cell	17 studies	50% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	32% ± 12%	Explore
microglial cell	16 studies	46% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	52% ± 16%	Explore
oligodendrocyte	15 studies	43% ± 17%	Explore
oligodendrocyte precursor cell	15 studies	56% ± 21%	Explore
mucosal invariant T cell	14 studies	42% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	42% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	30% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	50% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	48% ± 19%	Explore
glutamatergic neuron	11 studies	58% ± 26%	Explore
adipocyte	11 studies	45% ± 13%	Explore
basal cell	10 studies	30% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	40% ± 19%	Explore
non-classical monocyte	10 studies	26% ± 13%	Explore
GABAergic neuron	10 studies	38% ± 17%	Explore
neuron	9 studies	40% ± 18%	Explore
myeloid cell	9 studies	34% ± 9%	Explore
myofibroblast cell	9 studies	33% ± 8%	Explore
dendritic cell	8 studies	29% ± 14%	Explore
monocyte	8 studies	26% ± 7%	Explore
innate lymphoid cell	8 studies	38% ± 17%	Explore
naive B cell	8 studies	19% ± 2%	Explore
connective tissue cell	8 studies	27% ± 8%	Explore
epithelial cell	8 studies	30% ± 14%	Explore
B cell	7 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	7 studies	20% ± 3%	Explore
classical monocyte	7 studies	26% ± 8%	Explore
amacrine cell	7 studies	29% ± 9%	Explore
retinal rod cell	7 studies	35% ± 22%	Explore
leukocyte	6 studies	40% ± 11%	Explore
hepatocyte	6 studies	51% ± 25%	Explore
interneuron	6 studies	35% ± 17%	Explore
Mueller cell	6 studies	41% ± 8%	Explore
CD4-positive helper T cell	5 studies	32% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	34% ± 11%	Explore
exhausted T cell	5 studies	30% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	34% ± 13%	Explore
conventional dendritic cell	5 studies	31% ± 12%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 2%	Explore
hematopoietic stem cell	5 studies	29% ± 10%	Explore
adventitial cell	5 studies	40% ± 9%	Explore
cardiac muscle cell	5 studies	52% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	49% ± 17%	Explore
myoepithelial cell	5 studies	49% ± 16%	Explore
endothelial cell of lymphatic vessel	4 studies	21% ± 2%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	48% ± 22%	Explore
hematopoietic precursor cell	4 studies	43% ± 14%	Explore
secretory cell	4 studies	19% ± 3%	Explore
plasmablast	4 studies	32% ± 23%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	35% ± 10%	Explore
erythrocyte	4 studies	24% ± 6%	Explore
progenitor cell	4 studies	24% ± 12%	Explore
glial cell	4 studies	28% ± 9%	Explore
lymphocyte	4 studies	49% ± 23%	Explore
precursor B cell	4 studies	34% ± 13%	Explore
pro-B cell	4 studies	37% ± 15%	Explore
type I pneumocyte	4 studies	20% ± 5%	Explore
mesothelial cell	4 studies	29% ± 14%	Explore
goblet cell	4 studies	21% ± 4%	Explore
platelet	3 studies	18% ± 1%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	44% ± 16%	Explore
GABAergic interneuron	3 studies	33% ± 7%	Explore
retinal ganglion cell	3 studies	26% ± 6%	Explore
common myeloid progenitor	3 studies	26% ± 12%	Explore
mononuclear phagocyte	3 studies	26% ± 10%	Explore
ciliated cell	3 studies	23% ± 9%	Explore
ON-bipolar cell	3 studies	20% ± 3%	Explore
glycinergic amacrine cell	3 studies	33% ± 5%	Explore
abnormal cell	3 studies	31% ± 12%	Explore
intestinal crypt stem cell	3 studies	30% ± 9%	Explore
alveolar macrophage	3 studies	29% ± 11%	Explore
chondrocyte	3 studies	36% ± 22%	Explore
T follicular helper cell	3 studies	41% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	38% ± 14%	Explore
Schwann cell	3 studies	43% ± 17%	Explore
melanocyte	3 studies	30% ± 11%	Explore
transit amplifying cell	3 studies	27% ± 13%	Explore
granule cell	3 studies	28% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 7%	Explore
double negative thymocyte	3 studies	50% ± 21%	Explore
double-positive, alpha-beta thymocyte	3 studies	41% ± 18%	Explore
memory B cell	3 studies	18% ± 5%	Explore
mural cell	3 studies	40% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	42% ± 22%	Explore
peripheral blood	16 studies	31% ± 13%	Explore
lung	11 studies	23% ± 8%	Explore
eye	9 studies	27% ± 8%	Explore
intestine	7 studies	20% ± 4%	Explore
liver	6 studies	33% ± 12%	Explore
heart	5 studies	31% ± 10%	Explore
bone marrow	4 studies	30% ± 11%	Explore
uterus	4 studies	32% ± 5%	Explore
breast	4 studies	24% ± 6%	Explore
adipose	4 studies	43% ± 16%	Explore
kidney	3 studies	27% ± 5%	Explore
lymph node	3 studies	26% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	7054.29	2596 / 2642	100%	101.20	702 / 705
breast	100%	18655.68	459 / 459	98%	50.88	1091 / 1118
thymus	97%	5861.60	636 / 653	96%	29.52	580 / 605
prostate	98%	6758.10	240 / 245	91%	22.64	458 / 502
intestine	99%	10668.37	959 / 966	89%	17.72	469 / 527
lung	99%	9286.20	574 / 578	85%	17.88	979 / 1155
skin	99%	9406.51	1797 / 1809	85%	20.47	399 / 472
esophagus	95%	13480.35	1374 / 1445	87%	18.63	160 / 183
liver	96%	7156.62	217 / 226	86%	22.84	351 / 406
bladder	100%	9421.95	21 / 21	73%	15.77	369 / 504
uterus	100%	14849.96	170 / 170	67%	22.45	309 / 459
stomach	76%	5292.36	273 / 359	90%	21.16	258 / 286
kidney	79%	3079.01	70 / 89	87%	28.60	784 / 901
adrenal gland	80%	3151.15	206 / 258	85%	28.42	195 / 230
ovary	97%	9074.24	174 / 180	67%	12.06	289 / 430
pancreas	21%	600.16	68 / 328	87%	19.03	155 / 178
spleen	100%	6799.32	241 / 241	0%	0	0 / 0
adipose	100%	13003.49	1202 / 1204	0%	0	0 / 0
blood vessel	100%	10833.30	1330 / 1335	0%	0	0 / 0
muscle	96%	10960.64	774 / 803	0%	0	0 / 0
heart	84%	6170.52	720 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	73%	17.16	33 / 45
lymph node	0%	0	0 / 0	69%	14.14	20 / 29
peripheral blood	60%	3319.56	553 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	24%	2.78	19 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0046326	Biological process	positive regulation of glucose import
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0030316	Biological process	osteoclast differentiation
GO_0034644	Biological process	cellular response to UV
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0033120	Biological process	positive regulation of RNA splicing
GO_0048009	Biological process	insulin-like growth factor receptor signaling pathway
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0060396	Biological process	growth hormone receptor signaling pathway
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0001953	Biological process	negative regulation of cell-matrix adhesion
GO_0008625	Biological process	extrinsic apoptotic signaling pathway via death domain receptors
GO_0042307	Biological process	positive regulation of protein import into nucleus
GO_0046854	Biological process	phosphatidylinositol phosphate biosynthetic process
GO_0001678	Biological process	intracellular glucose homeostasis
GO_0042267	Biological process	natural killer cell mediated cytotoxicity
GO_0006955	Biological process	immune response
GO_0030217	Biological process	T cell differentiation
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0051491	Biological process	positive regulation of filopodium assembly
GO_0008286	Biological process	insulin receptor signaling pathway
GO_1900103	Biological process	positive regulation of endoplasmic reticulum unfolded protein response
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0051497	Biological process	negative regulation of stress fiber assembly
GO_0050821	Biological process	protein stabilization
GO_0008630	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage
GO_0006606	Biological process	protein import into nucleus
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0002687	Biological process	positive regulation of leukocyte migration
GO_0120183	Biological process	positive regulation of focal adhesion disassembly
GO_0035655	Biological process	interleukin-18-mediated signaling pathway
GO_0097529	Biological process	myeloid leukocyte migration
GO_0034143	Biological process	regulation of toll-like receptor 4 signaling pathway
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0030183	Biological process	B cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0045671	Biological process	negative regulation of osteoclast differentiation
GO_0005801	Cellular component	cis-Golgi network
GO_0005886	Cellular component	plasma membrane
GO_0005942	Cellular component	phosphatidylinositol 3-kinase complex
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005911	Cellular component	cell-cell junction
GO_0005943	Cellular component	phosphatidylinositol 3-kinase complex, class IA
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_1990578	Cellular component	perinuclear endoplasmic reticulum membrane
GO_0005634	Cellular component	nucleus
GO_0052742	Molecular function	phosphatidylinositol kinase activity
GO_0035014	Molecular function	phosphatidylinositol 3-kinase regulator activity
GO_0005158	Molecular function	insulin receptor binding
GO_0141038	Molecular function	phosphatidylinositol 3-kinase activator activity
GO_0043548	Molecular function	phosphatidylinositol 3-kinase binding
GO_0005159	Molecular function	insulin-like growth factor receptor binding
GO_0019903	Molecular function	protein phosphatase binding
GO_0140767	Molecular function	enzyme-substrate adaptor activity
GO_0046935	Molecular function	1-phosphatidylinositol-3-kinase regulator activity
GO_0043560	Molecular function	insulin receptor substrate binding
GO_0005068	Molecular function	transmembrane receptor protein tyrosine kinase adaptor activity
GO_0043559	Molecular function	insulin binding
GO_0019209	Molecular function	kinase activator activity
GO_0043125	Molecular function	ErbB-3 class receptor binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0036312	Molecular function	phosphatidylinositol 3-kinase regulatory subunit binding
GO_0005515	Molecular function	protein binding
GO_0001784	Molecular function	phosphotyrosine residue binding
GO_0005168	Molecular function	neurotrophin TRKA receptor binding

IV. Literature review

[source]

Gene name	PIK3R1
Protein name	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) Phosphoinositide-3-kinase regulatory subunit 1 (cDNA FLJ44373 fis, clone TRACH3009455, highly similar to Phosphatidylinositol 3-kinase regulatory subunit alpha) Phosphoinositide-3-kinase regulatory subunit PIK3R1/NR4A3 fusion protein Phosphoinositide-3-kinase regulatory subunit 1 Phosphatidylinositol 3-kinase regulatory subunit alpha (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha)
Synonyms	NR4A3 fusion GRB1
Description	FUNCTION: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling . Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement . .
Accessions	J7GU64 ENST00000697461.1 [P27986-4] A0A8V8TLF7 ENST00000519025.5 ENST00000520675.1 ENST00000697460.1 ENST00000697458.1 [P27986-1] ENST00000517698.6 A0A1D8GZE1 ENST00000697467.1 [P27986-5] ENST00000320694.13 [P27986-3] ENST00000522084.6 ENST00000697466.1 H0YB27 A0A8V8TMF9 J7GXU7 H0YBC2 A0A8V8TMF4 ENST00000697464.1 ENST00000697557.1 E5RK66 ENST00000697457.1 E5RGI8 A0A8V8TL14 ENST00000697469.1 ENST00000523807.5 ENST00000336483.10 [P27986-2] P27986 A0A8V8TLF1 ENST00000697465.1 E5RHI0 ENST00000521409.5 ENST00000697556.1 A0A8V8TL31 A0A8V8TME9 A0A8V8TLE6 ENST00000517643.2 [P27986-1] ENST00000697470.1 ENST00000697468.1 E5RJY0 ENST00000521657.6 [P27986-1] A0A8V8TL10 ENST00000697462.1 A0A2X0SFG1 B3KWZ7 ENST00000521381.6 [P27986-1] ENST00000523872.1 [P27986-5]

PIK3R1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review