DEDD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0035556Biological processintracellular signal transduction
GO_0016075Biological processrRNA catabolic process
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0030262Biological processapoptotic nuclear changes
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0019725Biological processcellular homeostasis
GO_0006396Biological processRNA processing
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0003677Molecular functionDNA binding
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDEDD2
Protein nameDeath effector domain containing 2
DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3)
SynonymsFLAME3
PSEC0004
DescriptionFUNCTION: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

AccessionsENST00000336034.8 [Q8WXF8-2]
ENST00000596251.6 [Q8WXF8-1]
ENST00000595337.5 [Q8WXF8-1]
M0QYK9
ENST00000598200.1
M0QXK7
ENST00000598727.5
Q8WXF8