Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 19 studies | 42% ± 20% | |
endothelial cell | 19 studies | 31% ± 10% | |
oligodendrocyte | 15 studies | 41% ± 15% | |
oligodendrocyte precursor cell | 13 studies | 38% ± 17% | |
microglial cell | 10 studies | 25% ± 9% | |
fibroblast | 10 studies | 26% ± 9% | |
adipocyte | 9 studies | 39% ± 10% | |
macrophage | 8 studies | 21% ± 4% | |
GABAergic neuron | 7 studies | 46% ± 18% | |
smooth muscle cell | 7 studies | 21% ± 6% | |
glutamatergic neuron | 6 studies | 41% ± 20% | |
interneuron | 6 studies | 38% ± 23% | |
endothelial cell of lymphatic vessel | 6 studies | 27% ± 6% | |
pericyte | 6 studies | 23% ± 7% | |
retina horizontal cell | 5 studies | 47% ± 17% | |
retinal cone cell | 5 studies | 41% ± 16% | |
cardiac muscle cell | 5 studies | 60% ± 16% | |
ciliated cell | 5 studies | 32% ± 13% | |
type I pneumocyte | 5 studies | 29% ± 5% | |
type II pneumocyte | 5 studies | 26% ± 4% | |
hepatocyte | 4 studies | 61% ± 28% | |
granule cell | 4 studies | 23% ± 5% | |
mesothelial cell | 4 studies | 28% ± 8% | |
epithelial cell | 4 studies | 35% ± 15% | |
Mueller cell | 4 studies | 35% ± 11% | |
amacrine cell | 4 studies | 22% ± 9% | |
retinal rod cell | 4 studies | 51% ± 15% | |
club cell | 4 studies | 25% ± 4% | |
GABAergic interneuron | 3 studies | 23% ± 5% | |
glial cell | 3 studies | 30% ± 2% | |
progenitor cell | 3 studies | 26% ± 3% | |
plasma cell | 3 studies | 24% ± 6% | |
glycinergic amacrine cell | 3 studies | 20% ± 3% | |
endothelial cell of vascular tree | 3 studies | 26% ± 12% | |
retinal pigment epithelial cell | 3 studies | 38% ± 22% | |
ependymal cell | 3 studies | 48% ± 20% | |
T cell | 3 studies | 20% ± 2% | |
capillary endothelial cell | 3 studies | 19% ± 2% | |
natural killer cell | 3 studies | 18% ± 3% | |
respiratory goblet cell | 3 studies | 30% ± 12% | |
lymphocyte | 3 studies | 26% ± 4% | |
basal cell | 3 studies | 31% ± 15% | |
neuron | 3 studies | 51% ± 17% | |
mucus secreting cell | 3 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 390.02 | 2639 / 2642 | 100% | 10.58 | 705 / 705 |
prostate | 100% | 637.54 | 245 / 245 | 100% | 11.93 | 500 / 502 |
liver | 100% | 916.81 | 226 / 226 | 99% | 11.46 | 403 / 406 |
stomach | 100% | 483.03 | 359 / 359 | 99% | 5.21 | 283 / 286 |
kidney | 100% | 724.52 | 89 / 89 | 99% | 10.74 | 890 / 901 |
lung | 100% | 505.08 | 577 / 578 | 99% | 7.16 | 1139 / 1155 |
pancreas | 99% | 332.77 | 326 / 328 | 99% | 5.86 | 176 / 178 |
thymus | 100% | 506.99 | 652 / 653 | 98% | 8.06 | 594 / 605 |
breast | 100% | 534.51 | 459 / 459 | 98% | 6.82 | 1094 / 1118 |
adrenal gland | 100% | 1013.38 | 258 / 258 | 97% | 13.58 | 224 / 230 |
intestine | 100% | 606.36 | 966 / 966 | 97% | 5.53 | 513 / 527 |
bladder | 100% | 628.62 | 21 / 21 | 97% | 6.12 | 490 / 504 |
uterus | 100% | 629.35 | 170 / 170 | 96% | 6.19 | 441 / 459 |
skin | 100% | 565.72 | 1809 / 1809 | 95% | 7.59 | 448 / 472 |
esophagus | 100% | 541.18 | 1445 / 1445 | 94% | 4.04 | 172 / 183 |
ovary | 100% | 476.62 | 180 / 180 | 89% | 3.82 | 382 / 430 |
adipose | 100% | 482.44 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 617.59 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 511.03 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 7.05 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.52 | 1 / 1 |
blood vessel | 100% | 605.15 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 950.63 | 854 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 97% | 5.68 | 28 / 29 |
peripheral blood | 89% | 292.50 | 827 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 80% | 3.78 | 64 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006974 | Biological process | DNA damage response |
GO_0097190 | Biological process | apoptotic signaling pathway |
GO_0006919 | Biological process | activation of cysteine-type endopeptidase activity involved in apoptotic process |
GO_0008625 | Biological process | extrinsic apoptotic signaling pathway via death domain receptors |
GO_2001235 | Biological process | positive regulation of apoptotic signaling pathway |
GO_0071260 | Biological process | cellular response to mechanical stimulus |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0006977 | Biological process | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
GO_0005730 | Cellular component | nucleolus |
GO_0005829 | Cellular component | cytosol |
GO_1905369 | Cellular component | endopeptidase complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0002020 | Molecular function | protease binding |
GO_0070513 | Molecular function | death domain binding |
GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | CRADD |
Protein name | Death domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain) CRADD protein CASP2 and RIPK1 domain containing adaptor with death domain (CRADD protein) (cDNA, FLJ95760, Homo sapiens CASP2 and RIPK1 domain containing adaptor with deathdomain (CRADD), mRNA) CASP2 and RIPK1 domain containing adaptor with death domain |
Synonyms | hCG_40089 RAIDD |
Description | FUNCTION: Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis . Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway . . |
Accessions | F8VVY5 ENST00000542893.2 [P78560-1] ENST00000332896.8 [P78560-1] ENST00000551065.5 [P78560-2] ENST00000552033.5 ENST00000552983.5 Q8IY43 F5H7C2 P78560 F8VV49 Q53XL1 B5BU44 ENST00000548483.5 |