CRADD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0097190Biological processapoptotic signaling pathway
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0071260Biological processcellular response to mechanical stimulus
GO_0043065Biological processpositive regulation of apoptotic process
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0005730Cellular componentnucleolus
GO_0005829Cellular componentcytosol
GO_1905369Cellular componentendopeptidase complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0002020Molecular functionprotease binding
GO_0070513Molecular functiondeath domain binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCRADD
Protein nameDeath domain-containing protein CRADD (Caspase and RIP adapter with death domain) (RIP-associated protein with a death domain)
CRADD protein
CASP2 and RIPK1 domain containing adaptor with death domain (CRADD protein) (cDNA, FLJ95760, Homo sapiens CASP2 and RIPK1 domain containing adaptor with deathdomain (CRADD), mRNA)
CASP2 and RIPK1 domain containing adaptor with death domain
SynonymshCG_40089
RAIDD
DescriptionFUNCTION: Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis . Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway . .

AccessionsF8VVY5
ENST00000542893.2 [P78560-1]
ENST00000332896.8 [P78560-1]
ENST00000551065.5 [P78560-2]
ENST00000552033.5
ENST00000552983.5
Q8IY43
F5H7C2
P78560
F8VV49
Q53XL1
B5BU44
ENST00000548483.5