BCL2 | OmnibusX

Name	Number of supported studies	Average coverage
B cell	26 studies	32% ± 15%	Explore
regulatory T cell	22 studies	30% ± 13%	Explore
astrocyte	18 studies	53% ± 23%	Explore
CD4-positive, alpha-beta T cell	18 studies	28% ± 13%	Explore
T cell	15 studies	31% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	30% ± 11%	Explore
memory B cell	14 studies	24% ± 8%	Explore
microglial cell	13 studies	38% ± 13%	Explore
mucosal invariant T cell	12 studies	25% ± 11%	Explore
naive B cell	11 studies	27% ± 9%	Explore
oligodendrocyte	11 studies	31% ± 14%	Explore
macrophage	10 studies	29% ± 15%	Explore
CD8-positive, alpha-beta T cell	10 studies	23% ± 10%	Explore
adipocyte	10 studies	70% ± 17%	Explore
smooth muscle cell	10 studies	25% ± 10%	Explore
GABAergic neuron	9 studies	35% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	25% ± 5%	Explore
oligodendrocyte precursor cell	9 studies	29% ± 7%	Explore
fibroblast	9 studies	26% ± 8%	Explore
endothelial cell	8 studies	35% ± 15%	Explore
glutamatergic neuron	8 studies	38% ± 22%	Explore
dendritic cell	7 studies	28% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	30% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	25% ± 6%	Explore
gamma-delta T cell	7 studies	20% ± 5%	Explore
natural killer cell	6 studies	30% ± 6%	Explore
plasma cell	6 studies	30% ± 14%	Explore
leukocyte	6 studies	37% ± 17%	Explore
mast cell	6 studies	28% ± 10%	Explore
myeloid cell	6 studies	25% ± 5%	Explore
ionocyte	5 studies	28% ± 10%	Explore
neuron	5 studies	29% ± 15%	Explore
pericyte	5 studies	41% ± 13%	Explore
epithelial cell	5 studies	20% ± 7%	Explore
interneuron	5 studies	40% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	24% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 7%	Explore
mature NK T cell	5 studies	30% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	25% ± 8%	Explore
lymphocyte	4 studies	49% ± 17%	Explore
Mueller cell	4 studies	37% ± 10%	Explore
myofibroblast cell	4 studies	32% ± 12%	Explore
cholangiocyte	3 studies	40% ± 15%	Explore
conventional dendritic cell	3 studies	34% ± 9%	Explore
GABAergic interneuron	3 studies	25% ± 5%	Explore
glial cell	3 studies	46% ± 22%	Explore
ependymal cell	3 studies	48% ± 18%	Explore
monocyte	3 studies	20% ± 4%	Explore
T follicular helper cell	3 studies	27% ± 10%	Explore
Schwann cell	3 studies	55% ± 29%	Explore
melanocyte	3 studies	54% ± 30%	Explore
T-helper 17 cell	3 studies	23% ± 6%	Explore
cardiac muscle cell	3 studies	24% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	28% ± 6%	Explore
mural cell	3 studies	35% ± 16%	Explore

Name	Number of supported studies	Average coverage
brain	16 studies	32% ± 17%	Explore
peripheral blood	6 studies	21% ± 7%	Explore
lung	4 studies	18% ± 2%	Explore
adipose	4 studies	24% ± 6%	Explore
lymph node	3 studies	19% ± 2%	Explore
heart	3 studies	21% ± 1%	Explore
kidney	3 studies	30% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	5505.84	653 / 653	96%	20.16	581 / 605
kidney	97%	1448.42	86 / 89	96%	26.65	863 / 901
breast	100%	3456.87	458 / 459	88%	30.77	982 / 1118
brain	94%	1462.41	2480 / 2642	92%	9.60	646 / 705
prostate	100%	2322.44	245 / 245	70%	6.44	350 / 502
skin	79%	1168.20	1431 / 1809	85%	14.20	403 / 472
lung	98%	1274.99	565 / 578	46%	5.42	536 / 1155
uterus	100%	4549.01	170 / 170	41%	5.39	186 / 459
ovary	100%	3850.99	180 / 180	24%	1.87	105 / 430
intestine	100%	2289.02	964 / 966	23%	1.63	121 / 527
bladder	100%	1901.48	21 / 21	18%	2.22	93 / 504
esophagus	92%	1752.31	1331 / 1445	23%	2.07	43 / 183
adipose	100%	3059.28	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	30.52	80 / 80
spleen	100%	3571.72	241 / 241	0%	0	0 / 0
blood vessel	100%	2046.95	1332 / 1335	0%	0	0 / 0
muscle	93%	1827.98	748 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	32.04	27 / 29
stomach	57%	938.96	206 / 359	27%	1.83	77 / 286
heart	81%	784.04	695 / 861	0%	0	0 / 0
peripheral blood	70%	4213.82	653 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	67%	10.75	30 / 45
pancreas	24%	160.75	80 / 328	34%	2.55	61 / 178
adrenal gland	8%	56.90	21 / 258	40%	3.86	92 / 230
liver	4%	26.89	10 / 226	10%	0.92	42 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002326	Biological process	B cell lineage commitment
GO_0042542	Biological process	response to hydrogen peroxide
GO_0010468	Biological process	regulation of gene expression
GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0003014	Biological process	renal system process
GO_0033689	Biological process	negative regulation of osteoblast proliferation
GO_0051924	Biological process	regulation of calcium ion transport
GO_0001541	Biological process	ovarian follicle development
GO_0010332	Biological process	response to gamma radiation
GO_0001656	Biological process	metanephros development
GO_0048741	Biological process	skeletal muscle fiber development
GO_0010224	Biological process	response to UV-B
GO_0006959	Biological process	humoral immune response
GO_0060218	Biological process	hematopoietic stem cell differentiation
GO_0051402	Biological process	neuron apoptotic process
GO_0048599	Biological process	oocyte development
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0097192	Biological process	extrinsic apoptotic signaling pathway in absence of ligand
GO_0035094	Biological process	response to nicotine
GO_1902166	Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_2000672	Biological process	negative regulation of motor neuron apoptotic process
GO_2001234	Biological process	negative regulation of apoptotic signaling pathway
GO_0001662	Biological process	behavioral fear response
GO_0060402	Biological process	calcium ion transport into cytosol
GO_0006914	Biological process	autophagy
GO_2001243	Biological process	negative regulation of intrinsic apoptotic signaling pathway
GO_0043583	Biological process	ear development
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0048743	Biological process	positive regulation of skeletal muscle fiber development
GO_0030279	Biological process	negative regulation of ossification
GO_0043029	Biological process	T cell homeostasis
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0010039	Biological process	response to iron ion
GO_0002931	Biological process	response to ischemia
GO_0000209	Biological process	protein polyubiquitination
GO_0045636	Biological process	positive regulation of melanocyte differentiation
GO_0009314	Biological process	response to radiation
GO_0032880	Biological process	regulation of protein localization
GO_2000811	Biological process	negative regulation of anoikis
GO_0007565	Biological process	female pregnancy
GO_0014911	Biological process	positive regulation of smooth muscle cell migration
GO_0072593	Biological process	reactive oxygen species metabolic process
GO_0097048	Biological process	dendritic cell apoptotic process
GO_0033077	Biological process	T cell differentiation in thymus
GO_0046666	Biological process	retinal cell programmed cell death
GO_0008630	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage
GO_0022612	Biological process	gland morphogenesis
GO_0010559	Biological process	regulation of glycoprotein biosynthetic process
GO_0030336	Biological process	negative regulation of cell migration
GO_0032835	Biological process	glomerulus development
GO_0008631	Biological process	intrinsic apoptotic signaling pathway in response to oxidative stress
GO_0048546	Biological process	digestive tract morphogenesis
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0010523	Biological process	negative regulation of calcium ion transport into cytosol
GO_0030308	Biological process	negative regulation of cell growth
GO_0035265	Biological process	organ growth
GO_0033687	Biological process	osteoblast proliferation
GO_0042149	Biological process	cellular response to glucose starvation
GO_0070059	Biological process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0031103	Biological process	axon regeneration
GO_0048753	Biological process	pigment granule organization
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0031069	Biological process	hair follicle morphogenesis
GO_0050853	Biological process	B cell receptor signaling pathway
GO_0008625	Biological process	extrinsic apoptotic signaling pathway via death domain receptors
GO_0001782	Biological process	B cell homeostasis
GO_0001952	Biological process	regulation of cell-matrix adhesion
GO_0033033	Biological process	negative regulation of myeloid cell apoptotic process
GO_0045069	Biological process	regulation of viral genome replication
GO_0070231	Biological process	T cell apoptotic process
GO_0007409	Biological process	axonogenesis
GO_0046671	Biological process	negative regulation of retinal cell programmed cell death
GO_0042551	Biological process	neuron maturation
GO_0048538	Biological process	thymus development
GO_0030890	Biological process	positive regulation of B cell proliferation
GO_1904036	Biological process	negative regulation of epithelial cell apoptotic process
GO_0001836	Biological process	release of cytochrome c from mitochondria
GO_0006582	Biological process	melanin metabolic process
GO_0048041	Biological process	focal adhesion assembly
GO_1904019	Biological process	epithelial cell apoptotic process
GO_0008584	Biological process	male gonad development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0014042	Biological process	positive regulation of neuron maturation
GO_0042100	Biological process	B cell proliferation
GO_0046902	Biological process	regulation of mitochondrial membrane permeability
GO_0009636	Biological process	response to toxic substance
GO_0002320	Biological process	lymphoid progenitor cell differentiation
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0021747	Biological process	cochlear nucleus development
GO_0070233	Biological process	negative regulation of T cell apoptotic process
GO_0014909	Biological process	smooth muscle cell migration
GO_0009791	Biological process	post-embryonic development
GO_0033028	Biological process	myeloid cell apoptotic process
GO_0030307	Biological process	positive regulation of cell growth
GO_0043375	Biological process	CD8-positive, alpha-beta T cell lineage commitment
GO_0001783	Biological process	B cell apoptotic process
GO_0034097	Biological process	response to cytokine
GO_0051607	Biological process	defense response to virus
GO_0006974	Biological process	DNA damage response
GO_0006808	Biological process	regulation of nitrogen utilization
GO_0002903	Biological process	negative regulation of B cell apoptotic process
GO_2000378	Biological process	negative regulation of reactive oxygen species metabolic process
GO_0048864	Biological process	stem cell development
GO_0051649	Biological process	establishment of localization in cell
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0048536	Biological process	spleen development
GO_0051881	Biological process	regulation of mitochondrial membrane potential
GO_0014031	Biological process	mesenchymal cell development
GO_0030318	Biological process	melanocyte differentiation
GO_0051384	Biological process	response to glucocorticoid
GO_0051902	Biological process	negative regulation of mitochondrial depolarization
GO_0007015	Biological process	actin filament organization
GO_0010507	Biological process	negative regulation of autophagy
GO_0032848	Biological process	negative regulation of cellular pH reduction
GO_0006915	Biological process	apoptotic process
GO_2000134	Biological process	negative regulation of G1/S transition of mitotic cell cycle
GO_0097049	Biological process	motor neuron apoptotic process
GO_2001240	Biological process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0001503	Biological process	ossification
GO_2000669	Biological process	negative regulation of dendritic cell apoptotic process
GO_0098609	Biological process	cell-cell adhesion
GO_0022898	Biological process	regulation of transmembrane transporter activity
GO_0032469	Biological process	endoplasmic reticulum calcium ion homeostasis
GO_0031647	Biological process	regulation of protein stability
GO_0071456	Biological process	cellular response to hypoxia
GO_0097138	Cellular component	BAD-BCL-2 complex
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005634	Cellular component	nucleus
GO_0046930	Cellular component	pore complex
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0032991	Cellular component	protein-containing complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0043209	Cellular component	myelin sheath
GO_0005829	Cellular component	cytosol
GO_0031965	Cellular component	nuclear membrane
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0016248	Molecular function	channel inhibitor activity
GO_0015267	Molecular function	channel activity
GO_0042802	Molecular function	identical protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0051400	Molecular function	BH domain binding
GO_0051721	Molecular function	protein phosphatase 2A binding
GO_0051434	Molecular function	BH3 domain binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0043565	Molecular function	sequence-specific DNA binding
GO_0002020	Molecular function	protease binding
GO_0005515	Molecular function	protein binding

Gene name	BCL2
Protein name	Apoptosis regulator Bcl-2 BCL2 protein BCL2 apoptosis regulator BCL2
Synonyms
Description	FUNCTION: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells . Regulates cell death by controlling the mitochondrial membrane permeability . Appears to function in a feedback loop system with caspases . Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release . .
Accessions	Q96PA0 A0N771 A0A1L4AQQ4 A0A1L4AQQ8 ENST00000398117.1 [P10415-1] P10415 ENST00000678349.1 [P10415-2] A0A1L4AQQ5 A0A1L4AQR6 ENST00000677227.1 A0A7I2V5Q9 A0A7I2V4W1 ENST00000590515.1 A0A1L4AQR0 ENST00000678134.1 A0A7I2V5Q7 A0A7I2V3S7 ENST00000678301.1 ENST00000589955.2 [P10415-2] ENST00000333681.5 [P10415-1]

BCL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review