DEDD report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DEDD at tissue level.

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0042981Biological processregulation of apoptotic process
GO_0007283Biological processspermatogenesis
GO_1901837Biological processnegative regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO_0046697Biological processdecidualization
GO_0005730Cellular componentnucleolus
GO_0005737Cellular componentcytoplasm
GO_0003677Molecular functionDNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDEDD
Protein nameDeath effector domain-containing protein (DEDPro1) (Death effector domain-containing testicular molecule) (FLDED-1)
Death effector domain containing
SynonymsKE05
DEDPRO1
hCG_20845
DEFT
DescriptionFUNCTION: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). .

AccessionsO75618
ENST00000368005.5
ENST00000458050.6 [O75618-1]
ENST00000368006.8 [O75618-1]
ENST00000545495.5 [O75618-1]
ENST00000490843.6 [O75618-1]
B1AQP5
ENST00000464113.1
V9GY27