Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 6 studies | 18% ± 4% | |
CD16-negative, CD56-bright natural killer cell, human | 5 studies | 17% ± 1% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 21% ± 3% | |
B cell | 4 studies | 18% ± 2% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 4 studies | 22% ± 5% | |
endothelial cell | 4 studies | 21% ± 3% | |
retinal ganglion cell | 4 studies | 73% ± 25% | |
amacrine cell | 4 studies | 37% ± 15% | |
CD4-positive, alpha-beta T cell | 3 studies | 25% ± 6% | |
retinal bipolar neuron | 3 studies | 32% ± 12% | |
mucosal invariant T cell | 3 studies | 16% ± 2% | |
epithelial cell | 3 studies | 36% ± 15% | |
retina horizontal cell | 3 studies | 29% ± 13% | |
retinal cone cell | 3 studies | 49% ± 20% | |
retinal rod cell | 3 studies | 28% ± 9% | |
Mueller cell | 3 studies | 17% ± 2% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 18% ± 2% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 18% ± 5% | |
neuron | 3 studies | 38% ± 21% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 8280.99 | 2641 / 2642 | 100% | 117.69 | 705 / 705 |
prostate | 100% | 2730.80 | 244 / 245 | 100% | 111.86 | 502 / 502 |
ovary | 100% | 2113.32 | 180 / 180 | 100% | 52.23 | 428 / 430 |
breast | 100% | 2107.75 | 459 / 459 | 99% | 61.98 | 1106 / 1118 |
thymus | 100% | 2265.30 | 651 / 653 | 99% | 70.83 | 600 / 605 |
kidney | 100% | 2619.04 | 89 / 89 | 99% | 60.50 | 889 / 901 |
lung | 99% | 2564.71 | 574 / 578 | 99% | 38.06 | 1144 / 1155 |
intestine | 100% | 3270.14 | 966 / 966 | 98% | 33.25 | 516 / 527 |
skin | 99% | 1658.58 | 1788 / 1809 | 98% | 57.13 | 463 / 472 |
stomach | 100% | 2447.91 | 359 / 359 | 97% | 29.51 | 277 / 286 |
bladder | 100% | 2760.52 | 21 / 21 | 97% | 31.50 | 488 / 504 |
uterus | 99% | 2042.21 | 169 / 170 | 95% | 35.42 | 438 / 459 |
adrenal gland | 100% | 3110.40 | 258 / 258 | 95% | 114.89 | 218 / 230 |
pancreas | 94% | 1180.73 | 307 / 328 | 99% | 44.72 | 177 / 178 |
esophagus | 97% | 3012.87 | 1404 / 1445 | 96% | 26.40 | 175 / 183 |
liver | 90% | 946.38 | 204 / 226 | 90% | 24.91 | 365 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 40.27 | 29 / 29 |
spleen | 100% | 2188.20 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3195.36 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 2863.91 | 802 / 803 | 0% | 0 | 0 / 0 |
adipose | 100% | 1935.41 | 1199 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 95% | 51.06 | 76 / 80 |
heart | 94% | 3321.33 | 810 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 20.75 | 41 / 45 |
peripheral blood | 68% | 1090.63 | 634 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0090200 | Biological process | positive regulation of release of cytochrome c from mitochondria |
GO_0097190 | Biological process | apoptotic signaling pathway |
GO_0006914 | Biological process | autophagy |
GO_0008625 | Biological process | extrinsic apoptotic signaling pathway via death domain receptors |
GO_2000786 | Biological process | positive regulation of autophagosome assembly |
GO_0042981 | Biological process | regulation of apoptotic process |
GO_0051204 | Biological process | protein insertion into mitochondrial membrane |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
GO_0008630 | Biological process | intrinsic apoptotic signaling pathway in response to DNA damage |
GO_0005741 | Cellular component | mitochondrial outer membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MOAP1 |
Protein name | Modulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4) |
Synonyms | PNMA4 |
Description | FUNCTION: Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis . Required for death receptor-dependent apoptosis . When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation . Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins . Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex . . |
Accessions | Q96BY2 ENST00000298894.5 ENST00000556883.1 ENST00000627896.1 ENST00000616515.2 |