MOAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_0097190Biological processapoptotic signaling pathway
GO_0006914Biological processautophagy
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_2000786Biological processpositive regulation of autophagosome assembly
GO_0042981Biological processregulation of apoptotic process
GO_0051204Biological processprotein insertion into mitochondrial membrane
GO_0043065Biological processpositive regulation of apoptotic process
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMOAP1
Protein nameModulator of apoptosis 1 (MAP-1) (MAP1) (Paraneoplastic antigen Ma4)
SynonymsPNMA4
DescriptionFUNCTION: Retrotransposon-derived protein that forms virion-like capsids (By similarity). Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis . Required for death receptor-dependent apoptosis . When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation . Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins . Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex . .

AccessionsQ96BY2
ENST00000298894.5
ENST00000556883.1
ENST00000627896.1
ENST00000616515.2