TNFRSF1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0006366Biological processtranscription by RNA polymerase II
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0072659Biological processprotein localization to plasma membrane
GO_0006954Biological processinflammatory response
GO_0071260Biological processcellular response to mechanical stimulus
GO_1905038Biological processregulation of membrane lipid metabolic process
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0003332Biological processnegative regulation of extracellular matrix constituent secretion
GO_0050728Biological processnegative regulation of inflammatory response
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_1902339Biological processpositive regulation of apoptotic process involved in morphogenesis
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0003176Biological processaortic valve development
GO_0006693Biological processprostaglandin metabolic process
GO_0042742Biological processdefense response to bacterium
GO_0003177Biological processpulmonary valve development
GO_0050729Biological processpositive regulation of inflammatory response
GO_0034250Biological processpositive regulation of amide metabolic process
GO_1903140Biological processregulation of establishment of endothelial barrier
GO_0045834Biological processpositive regulation of lipid metabolic process
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0010614Biological processnegative regulation of cardiac muscle hypertrophy
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0002947Cellular componenttumor necrosis factor receptor superfamily complex
GO_0005615Cellular componentextracellular space
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0043120Molecular functiontumor necrosis factor binding
GO_0005031Molecular functiontumor necrosis factor receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNFRSF1A
Protein nameTumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]
TNF receptor superfamily member 1A
Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (Tumor necrosis factor receptor type I) (p55) (p60)
Tumor necrosis factor receptor superfamily member 1A
SynonymsTNFAR
TNFR1
DescriptionFUNCTION: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

AccessionsENST00000539372.5
F5H4T5
F5GWJ4
J9PH39
ENST00000543048.5
ENST00000437813.8 [P19438-5]
ENST00000440083.7
ENST00000540022.5
F5H8A6
Q6Y4Q7
ENST00000698339.1 [P19438-5]
F5H6Z2
ENST00000162749.7 [P19438-1]
A0A8V8TLL5
F5H7N1
ENST00000536194.1
ENST00000535958.2
ENST00000534885.5
P19438
F5H6V7
ENST00000698340.1 [P19438-4]
ENST00000543995.5
F5H061