Name | Number of supported studies | Average coverage | |
---|---|---|---|
pericyte | 17 studies | 29% ± 9% | |
oligodendrocyte | 16 studies | 65% ± 17% | |
smooth muscle cell | 14 studies | 30% ± 9% | |
astrocyte | 13 studies | 37% ± 17% | |
endothelial cell | 13 studies | 44% ± 16% | |
microglial cell | 12 studies | 38% ± 15% | |
glutamatergic neuron | 10 studies | 47% ± 23% | |
adipocyte | 9 studies | 48% ± 16% | |
oligodendrocyte precursor cell | 8 studies | 36% ± 12% | |
ciliated cell | 7 studies | 23% ± 6% | |
myeloid cell | 7 studies | 20% ± 3% | |
epithelial cell | 7 studies | 30% ± 10% | |
type I pneumocyte | 7 studies | 27% ± 8% | |
alveolar macrophage | 6 studies | 31% ± 9% | |
macrophage | 6 studies | 30% ± 12% | |
GABAergic neuron | 6 studies | 47% ± 18% | |
classical monocyte | 5 studies | 23% ± 6% | |
neuron | 5 studies | 39% ± 18% | |
interneuron | 5 studies | 43% ± 25% | |
type II pneumocyte | 5 studies | 22% ± 4% | |
squamous epithelial cell | 4 studies | 43% ± 12% | |
non-classical monocyte | 4 studies | 26% ± 8% | |
retinal pigment epithelial cell | 4 studies | 47% ± 20% | |
cardiac muscle cell | 4 studies | 29% ± 4% | |
mast cell | 4 studies | 18% ± 2% | |
myofibroblast cell | 4 studies | 23% ± 5% | |
monocyte | 4 studies | 22% ± 3% | |
GABAergic interneuron | 3 studies | 22% ± 3% | |
muscle cell | 3 studies | 40% ± 21% | |
abnormal cell | 3 studies | 25% ± 8% | |
ependymal cell | 3 studies | 42% ± 20% | |
goblet cell | 3 studies | 17% ± 2% | |
club cell | 3 studies | 18% ± 2% | |
basal cell | 3 studies | 17% ± 1% | |
podocyte | 3 studies | 43% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 9202.99 | 651 / 653 | 97% | 69.44 | 587 / 605 |
breast | 98% | 8880.88 | 449 / 459 | 99% | 68.38 | 1103 / 1118 |
intestine | 98% | 7499.08 | 949 / 966 | 98% | 46.43 | 517 / 527 |
brain | 97% | 15548.71 | 2555 / 2642 | 100% | 111.62 | 702 / 705 |
kidney | 100% | 6768.43 | 89 / 89 | 94% | 43.11 | 849 / 901 |
lung | 99% | 13194.43 | 572 / 578 | 94% | 42.76 | 1087 / 1155 |
esophagus | 99% | 11702.12 | 1433 / 1445 | 93% | 48.73 | 171 / 183 |
skin | 93% | 5529.14 | 1676 / 1809 | 99% | 148.86 | 465 / 472 |
bladder | 95% | 5790.90 | 20 / 21 | 89% | 36.31 | 447 / 504 |
prostate | 85% | 5286.33 | 208 / 245 | 97% | 34.04 | 488 / 502 |
stomach | 84% | 4985.36 | 300 / 359 | 97% | 51.05 | 276 / 286 |
uterus | 93% | 6255.49 | 158 / 170 | 86% | 41.39 | 397 / 459 |
adrenal gland | 64% | 2865.60 | 165 / 258 | 83% | 33.15 | 191 / 230 |
pancreas | 46% | 1672.45 | 150 / 328 | 96% | 42.99 | 171 / 178 |
ovary | 18% | 1318.37 | 33 / 180 | 100% | 75.93 | 429 / 430 |
eye | 0% | 0 | 0 / 0 | 100% | 150.13 | 80 / 80 |
ureter | 0% | 0 | 0 / 0 | 100% | 30.84 | 1 / 1 |
blood vessel | 100% | 33433.84 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 16993.31 | 802 / 803 | 0% | 0 | 0 / 0 |
adipose | 98% | 10735.77 | 1180 / 1204 | 0% | 0 | 0 / 0 |
heart | 90% | 10039.34 | 776 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 84% | 31.64 | 38 / 45 |
liver | 7% | 265.98 | 16 / 226 | 60% | 16.98 | 245 / 406 |
spleen | 66% | 3008.24 | 158 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 53% | 6462.35 | 495 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 10% | 3.10 | 3 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0010468 | Biological process | regulation of gene expression |
GO_0007218 | Biological process | neuropeptide signaling pathway |
GO_0099558 | Biological process | maintenance of synapse structure |
GO_0006897 | Biological process | endocytosis |
GO_0006622 | Biological process | protein targeting to lysosome |
GO_0048011 | Biological process | neurotrophin TRK receptor signaling pathway |
GO_0014902 | Biological process | myotube differentiation |
GO_0008625 | Biological process | extrinsic apoptotic signaling pathway via death domain receptors |
GO_0032868 | Biological process | response to insulin |
GO_0045599 | Biological process | negative regulation of fat cell differentiation |
GO_0038180 | Biological process | nerve growth factor signaling pathway |
GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
GO_0016050 | Biological process | vesicle organization |
GO_0008333 | Biological process | endosome to lysosome transport |
GO_0090160 | Biological process | Golgi to lysosome transport |
GO_0032509 | Biological process | endosome transport via multivesicular body sorting pathway |
GO_0048227 | Biological process | plasma membrane to endosome transport |
GO_0001503 | Biological process | ossification |
GO_0046323 | Biological process | glucose import |
GO_0051005 | Biological process | negative regulation of lipoprotein lipase activity |
GO_0006895 | Biological process | Golgi to endosome transport |
GO_0005886 | Cellular component | plasma membrane |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005769 | Cellular component | early endosome |
GO_0005764 | Cellular component | lysosome |
GO_0030136 | Cellular component | clathrin-coated vesicle |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0009986 | Cellular component | cell surface |
GO_0005829 | Cellular component | cytosol |
GO_0030140 | Cellular component | trans-Golgi network transport vesicle |
GO_0010008 | Cellular component | endosome membrane |
GO_0005905 | Cellular component | clathrin-coated pit |
GO_0032580 | Cellular component | Golgi cisterna membrane |
GO_0031965 | Cellular component | nuclear membrane |
GO_0150053 | Cellular component | cerebellar climbing fiber to Purkinje cell synapse |
GO_0005765 | Cellular component | lysosomal membrane |
GO_1905394 | Molecular function | retromer complex binding |
GO_0019899 | Molecular function | enzyme binding |
GO_0030379 | Molecular function | neurotensin receptor activity, non-G protein-coupled |
GO_0048406 | Molecular function | nerve growth factor binding |
GO_0005515 | Molecular function | protein binding |
GO_0010465 | Molecular function | nerve growth factor receptor activity |
Gene name | SORT1 |
Protein name | Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3) Sortilin 1 |
Synonyms | |
Description | FUNCTION: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex . The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. . |
Accessions | Q99523 A0A0J9YY30 ENST00000633956.1 ENST00000256637.8 [Q99523-1] A0A0J9YVU2 ENST00000471996.1 ENST00000493736.5 A0A0J9YVX1 ENST00000538502.5 [Q99523-2] A0A0J9YX61 ENST00000482236.5 |