SORT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_0007218Biological processneuropeptide signaling pathway
GO_0099558Biological processmaintenance of synapse structure
GO_0006897Biological processendocytosis
GO_0006622Biological processprotein targeting to lysosome
GO_0048011Biological processneurotrophin TRK receptor signaling pathway
GO_0014902Biological processmyotube differentiation
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0032868Biological processresponse to insulin
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0038180Biological processnerve growth factor signaling pathway
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0016050Biological processvesicle organization
GO_0008333Biological processendosome to lysosome transport
GO_0090160Biological processGolgi to lysosome transport
GO_0032509Biological processendosome transport via multivesicular body sorting pathway
GO_0048227Biological processplasma membrane to endosome transport
GO_0001503Biological processossification
GO_0046323Biological processglucose import
GO_0051005Biological processnegative regulation of lipoprotein lipase activity
GO_0006895Biological processGolgi to endosome transport
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0005764Cellular componentlysosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0030140Cellular componenttrans-Golgi network transport vesicle
GO_0010008Cellular componentendosome membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0032580Cellular componentGolgi cisterna membrane
GO_0031965Cellular componentnuclear membrane
GO_0150053Cellular componentcerebellar climbing fiber to Purkinje cell synapse
GO_0005765Cellular componentlysosomal membrane
GO_1905394Molecular functionretromer complex binding
GO_0019899Molecular functionenzyme binding
GO_0030379Molecular functionneurotensin receptor activity, non-G protein-coupled
GO_0048406Molecular functionnerve growth factor binding
GO_0005515Molecular functionprotein binding
GO_0010465Molecular functionnerve growth factor receptor activity

IV. Literature review

[source]
Gene nameSORT1
Protein nameSortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)
Sortilin 1
Synonyms
DescriptionFUNCTION: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex . The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. .

AccessionsQ99523
A0A0J9YY30
ENST00000633956.1
ENST00000256637.8 [Q99523-1]
A0A0J9YVU2
ENST00000471996.1
ENST00000493736.5
A0A0J9YVX1
ENST00000538502.5 [Q99523-2]
A0A0J9YX61
ENST00000482236.5