BAG3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905337Biological processpositive regulation of aggrephagy
GO_0034620Biological processcellular response to unfolded protein
GO_0071260Biological processcellular response to mechanical stimulus
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0034605Biological processcellular response to heat
GO_0000045Biological processautophagosome assembly
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0098840Biological processprotein transport along microtubule
GO_0006457Biological processprotein folding
GO_0043066Biological processnegative regulation of apoptotic process
GO_0061684Biological processchaperone-mediated autophagy
GO_0050821Biological processprotein stabilization
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0010658Biological processstriated muscle cell apoptotic process
GO_0070842Biological processaggresome assembly
GO_0010664Biological processnegative regulation of striated muscle cell apoptotic process
GO_0016020Cellular componentmembrane
GO_0030018Cellular componentZ disc
GO_0005654Cellular componentnucleoplasm
GO_0001725Cellular componentstress fiber
GO_0101031Cellular componentprotein folding chaperone complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016235Cellular componentaggresome
GO_0005634Cellular componentnucleus
GO_0000774Molecular functionadenyl-nucleotide exchange factor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0045296Molecular functioncadherin binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0140597Molecular functionprotein carrier chaperone
GO_0045505Molecular functiondynein intermediate chain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBAG3
Protein nameBAG cochaperone 3
BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)
SynonymsBIS
DescriptionFUNCTION: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 . Has anti-apoptotic activity . Plays a role in the HSF1 nucleocytoplasmic transport . .

AccessionsENST00000450186.1
O95817
ENST00000369085.8
C9JFK9