Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 22 studies | 30% ± 15% | |
| fibroblast | 18 studies | 31% ± 13% | |
| smooth muscle cell | 16 studies | 32% ± 13% | |
| basal cell | 14 studies | 28% ± 8% | |
| macrophage | 13 studies | 28% ± 10% | |
| endothelial cell of vascular tree | 12 studies | 31% ± 11% | |
| pericyte | 11 studies | 31% ± 10% | |
| astrocyte | 10 studies | 30% ± 13% | |
| conventional dendritic cell | 7 studies | 27% ± 8% | |
| connective tissue cell | 7 studies | 24% ± 6% | |
| endothelial cell of artery | 7 studies | 22% ± 6% | |
| epithelial cell | 6 studies | 34% ± 14% | |
| monocyte | 5 studies | 26% ± 4% | |
| ciliated cell | 5 studies | 23% ± 8% | |
| type I pneumocyte | 4 studies | 21% ± 4% | |
| abnormal cell | 4 studies | 25% ± 8% | |
| secretory cell | 4 studies | 26% ± 4% | |
| myofibroblast cell | 4 studies | 31% ± 9% | |
| vein endothelial cell | 4 studies | 31% ± 7% | |
| leukocyte | 4 studies | 30% ± 15% | |
| T cell | 3 studies | 24% ± 5% | |
| CD4-positive, alpha-beta T cell | 3 studies | 23% ± 5% | |
| regulatory T cell | 3 studies | 16% ± 1% | |
| capillary endothelial cell | 3 studies | 27% ± 5% | |
| luminal cell of prostate epithelium | 3 studies | 24% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 7767.50 | 1444 / 1445 | 100% | 187.15 | 183 / 183 |
| skin | 100% | 6707.16 | 1808 / 1809 | 99% | 88.29 | 468 / 472 |
| prostate | 99% | 5009.73 | 243 / 245 | 100% | 100.71 | 500 / 502 |
| breast | 100% | 5060.05 | 457 / 459 | 99% | 122.68 | 1106 / 1118 |
| uterus | 100% | 4678.91 | 170 / 170 | 98% | 126.33 | 452 / 459 |
| lung | 99% | 9178.67 | 570 / 578 | 99% | 127.56 | 1147 / 1155 |
| bladder | 100% | 7251.90 | 21 / 21 | 98% | 90.28 | 493 / 504 |
| adrenal gland | 99% | 4487.16 | 256 / 258 | 98% | 170.88 | 225 / 230 |
| kidney | 98% | 4531.37 | 87 / 89 | 98% | 73.22 | 886 / 901 |
| stomach | 97% | 7136.76 | 349 / 359 | 99% | 70.90 | 282 / 286 |
| intestine | 94% | 6176.12 | 906 / 966 | 99% | 76.44 | 522 / 527 |
| thymus | 98% | 4090.59 | 638 / 653 | 91% | 88.74 | 551 / 605 |
| brain | 88% | 5852.48 | 2327 / 2642 | 99% | 96.83 | 697 / 705 |
| ovary | 88% | 3457.02 | 159 / 180 | 98% | 52.89 | 422 / 430 |
| liver | 57% | 2129.14 | 129 / 226 | 82% | 38.52 | 332 / 406 |
| pancreas | 32% | 709.85 | 105 / 328 | 98% | 95.55 | 174 / 178 |
| muscle | 100% | 34929.03 | 803 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 160.85 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 37.91 | 1 / 1 |
| adipose | 100% | 6738.13 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 7847.35 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 66.44 | 79 / 80 |
| heart | 96% | 11417.48 | 825 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 66% | 22.10 | 19 / 29 |
| spleen | 56% | 1504.70 | 135 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 29% | 1432.34 | 271 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1905337 | Biological process | positive regulation of aggrephagy |
| GO_0034620 | Biological process | cellular response to unfolded protein |
| GO_0071260 | Biological process | cellular response to mechanical stimulus |
| GO_0046716 | Biological process | muscle cell cellular homeostasis |
| GO_0034605 | Biological process | cellular response to heat |
| GO_0000045 | Biological process | autophagosome assembly |
| GO_0042307 | Biological process | positive regulation of protein import into nucleus |
| GO_0008625 | Biological process | extrinsic apoptotic signaling pathway via death domain receptors |
| GO_0046827 | Biological process | positive regulation of protein export from nucleus |
| GO_0098840 | Biological process | protein transport along microtubule |
| GO_0006457 | Biological process | protein folding |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0061684 | Biological process | chaperone-mediated autophagy |
| GO_0050821 | Biological process | protein stabilization |
| GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0010658 | Biological process | striated muscle cell apoptotic process |
| GO_0070842 | Biological process | aggresome assembly |
| GO_0010664 | Biological process | negative regulation of striated muscle cell apoptotic process |
| GO_0016020 | Cellular component | membrane |
| GO_0030018 | Cellular component | Z disc |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0001725 | Cellular component | stress fiber |
| GO_0101031 | Cellular component | protein folding chaperone complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016235 | Cellular component | aggresome |
| GO_0005634 | Cellular component | nucleus |
| GO_0000774 | Molecular function | adenyl-nucleotide exchange factor activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0051087 | Molecular function | protein-folding chaperone binding |
| GO_0140597 | Molecular function | protein carrier chaperone |
| GO_0045505 | Molecular function | dynein intermediate chain binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BAG3 |
| Protein name | BAG cochaperone 3 BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1) |
| Synonyms | BIS |
| Description | FUNCTION: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 . Has anti-apoptotic activity . Plays a role in the HSF1 nucleocytoplasmic transport . . |
| Accessions | ENST00000450186.1 O95817 ENST00000369085.8 C9JFK9 |