DELE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140468Biological processHRI-mediated signaling
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_1901526Biological processpositive regulation of mitophagy
GO_1990641Biological processresponse to iron ion starvation
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005829Cellular componentcytosol
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDELE1
Protein nameDAP3 binding cell death enhancer 1
DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1)]
SynonymsDELE
KIAA0141
DescriptionFUNCTION: Protein kinase activator that acts as a key activator of the integrated stress response (ISR) following various stresses, such as iron deficiency and mitochondrial stress . Detects impaired protein import and processing in mitochondria, activating the ISR . May also required for the induction of death receptor-mediated apoptosis through the regulation of caspase activation . .; FUNCTION: [DAP3-binding cell death enhancer 1]: Protein kinase activator that activates the ISR in response to iron deficiency: iron deficiency impairs mitochondrial import, promoting DELE1 localization at the mitochondrial surface, where it binds and activates EIF2AK1/HRI to trigger the ISR. .; FUNCTION: [DAP3-binding cell death enhancer 1 short form]: Protein kinase activator generated by protein cleavage in response to mitochondrial stress, which accumulates in the cytosol and specifically binds to and activates the protein kinase activity of EIF2AK1/HRI . It thereby activates the integrated stress response (ISR): EIF2AK1/HRI activation promotes eIF-2-alpha (EIF2S1) phosphorylation, leading to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, the master transcriptional regulator of the ISR . .

AccessionsENST00000194118.8
H0YA48
Q14154
ENST00000507481.2
ENST00000432126.7
D6RBI8
ENST00000508751.1