CASP8AP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0097190Biological processapoptotic signaling pathway
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0071260Biological processcellular response to mechanical stimulus
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0036337Biological processFas signaling pathway
GO_0005654Cellular componentnucleoplasm
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0005123Molecular functiondeath receptor binding
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_0016505Molecular functionpeptidase activator activity involved in apoptotic process
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0032184Molecular functionSUMO polymer binding

IV. Literature review

[source]
Gene nameCASP8AP2
Protein nameCASP8-associated protein 2 (FLICE-associated huge protein)
CASP8AP2 protein
Alternative protein CASP8AP2
Caspase 8 associated protein 2
SynonymsRIP25
FLASH
KIAA1315
DescriptionFUNCTION: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. .

AccessionsA0A087WTW5
Q9UKL3
ENST00000671703.2
ENST00000419040.6
L8EC81
ENST00000552401.5
ENST00000551025.4
A0A096LP21
A7E2C0