BEX3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	39 studies	51% ± 24%	Explore
endothelial cell	35 studies	45% ± 21%	Explore
pericyte	26 studies	53% ± 24%	Explore
smooth muscle cell	24 studies	53% ± 25%	Explore
basal cell	18 studies	39% ± 19%	Explore
connective tissue cell	18 studies	63% ± 24%	Explore
epithelial cell	18 studies	52% ± 27%	Explore
endothelial cell of lymphatic vessel	17 studies	51% ± 19%	Explore
astrocyte	13 studies	39% ± 23%	Explore
myofibroblast cell	13 studies	67% ± 25%	Explore
glutamatergic neuron	10 studies	47% ± 18%	Explore
mesothelial cell	10 studies	72% ± 25%	Explore
endothelial cell of vascular tree	10 studies	30% ± 10%	Explore
type I pneumocyte	9 studies	57% ± 19%	Explore
platelet	9 studies	59% ± 14%	Explore
capillary endothelial cell	9 studies	37% ± 21%	Explore
neuron	9 studies	63% ± 24%	Explore
oligodendrocyte	9 studies	29% ± 13%	Explore
endothelial cell of artery	9 studies	48% ± 21%	Explore
GABAergic neuron	9 studies	40% ± 18%	Explore
ciliated cell	9 studies	41% ± 17%	Explore
secretory cell	9 studies	47% ± 19%	Explore
type II pneumocyte	8 studies	59% ± 22%	Explore
vein endothelial cell	8 studies	47% ± 25%	Explore
hematopoietic stem cell	8 studies	48% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	55% ± 20%	Explore
abnormal cell	7 studies	59% ± 16%	Explore
goblet cell	7 studies	24% ± 9%	Explore
regulatory T cell	7 studies	21% ± 4%	Explore
oligodendrocyte precursor cell	7 studies	47% ± 24%	Explore
club cell	6 studies	43% ± 24%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	21% ± 3%	Explore
kidney loop of Henle epithelial cell	6 studies	75% ± 11%	Explore
progenitor cell	6 studies	76% ± 18%	Explore
renal alpha-intercalated cell	6 studies	64% ± 15%	Explore
megakaryocyte	6 studies	71% ± 22%	Explore
amacrine cell	6 studies	58% ± 27%	Explore
retinal ganglion cell	6 studies	66% ± 34%	Explore
interneuron	6 studies	51% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	84% ± 10%	Explore
enteroendocrine cell	5 studies	66% ± 23%	Explore
erythroblast	5 studies	23% ± 5%	Explore
intestinal crypt stem cell	5 studies	34% ± 9%	Explore
neuroendocrine cell	5 studies	69% ± 23%	Explore
transit amplifying cell	5 studies	25% ± 4%	Explore
hematopoietic precursor cell	4 studies	49% ± 16%	Explore
T cell	4 studies	46% ± 31%	Explore
macrophage	4 studies	28% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
glomerular endothelial cell	4 studies	58% ± 12%	Explore
retinal bipolar neuron	4 studies	55% ± 32%	Explore
OFF-bipolar cell	4 studies	54% ± 29%	Explore
ON-bipolar cell	4 studies	54% ± 29%	Explore
retina horizontal cell	4 studies	63% ± 17%	Explore
retinal pigment epithelial cell	4 studies	52% ± 24%	Explore
Mueller cell	4 studies	57% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 13%	Explore
luminal cell of prostate epithelium	4 studies	42% ± 17%	Explore
ionocyte	3 studies	28% ± 8%	Explore
pancreatic A cell	3 studies	74% ± 5%	Explore
type B pancreatic cell	3 studies	65% ± 6%	Explore
kidney connecting tubule epithelial cell	3 studies	84% ± 10%	Explore
podocyte	3 studies	81% ± 12%	Explore
enterocyte	3 studies	33% ± 15%	Explore
neural crest cell	3 studies	83% ± 16%	Explore
GABAergic amacrine cell	3 studies	62% ± 13%	Explore
glycinergic amacrine cell	3 studies	48% ± 13%	Explore
renal principal cell	3 studies	80% ± 7%	Explore
placental villous trophoblast	3 studies	81% ± 24%	Explore
common myeloid progenitor	3 studies	47% ± 23%	Explore
retinal cone cell	3 studies	52% ± 22%	Explore
adventitial cell	3 studies	35% ± 12%	Explore
myeloid cell	3 studies	37% ± 8%	Explore
rod bipolar cell	3 studies	62% ± 17%	Explore
muscle cell	3 studies	49% ± 16%	Explore
myoepithelial cell	3 studies	62% ± 21%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	63% ± 15%	Explore
glial cell	3 studies	52% ± 25%	Explore
hepatocyte	3 studies	45% ± 31%	Explore
melanocyte	3 studies	27% ± 7%	Explore
granule cell	3 studies	26% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	38% ± 15%	Explore
lung	12 studies	40% ± 21%	Explore
eye	9 studies	42% ± 15%	Explore
kidney	7 studies	48% ± 14%	Explore
intestine	6 studies	50% ± 23%	Explore
placenta	5 studies	43% ± 27%	Explore
pancreas	4 studies	48% ± 18%	Explore
uterus	4 studies	49% ± 17%	Explore
breast	4 studies	27% ± 6%	Explore
esophagus	3 studies	36% ± 28%	Explore
prostate	3 studies	31% ± 5%	Explore
skin	3 studies	30% ± 12%	Explore
thymus	3 studies	57% ± 18%	Explore
liver	3 studies	27% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	14676.06	2642 / 2642	100%	878.88	704 / 705
adrenal gland	100%	11956.02	258 / 258	100%	694.95	229 / 230
ovary	100%	15869.33	180 / 180	99%	455.85	427 / 430
thymus	100%	10582.97	653 / 653	99%	459.98	600 / 605
prostate	100%	6300.73	244 / 245	99%	418.41	497 / 502
kidney	100%	7018.16	89 / 89	96%	252.08	861 / 901
uterus	100%	5555.88	170 / 170	91%	376.75	417 / 459
bladder	100%	3998.48	21 / 21	86%	299.55	435 / 504
lung	99%	4347.47	571 / 578	86%	255.31	988 / 1155
breast	99%	4253.70	456 / 459	85%	224.51	946 / 1118
skin	86%	4276.56	1553 / 1809	95%	342.60	450 / 472
pancreas	77%	1671.17	251 / 328	98%	248.22	174 / 178
esophagus	94%	3455.55	1365 / 1445	57%	118.94	104 / 183
intestine	86%	3303.70	830 / 966	62%	105.11	327 / 527
stomach	76%	2558.09	273 / 359	46%	76.07	131 / 286
liver	47%	938.17	106 / 226	72%	200.46	292 / 406
eye	0%	0	0 / 0	100%	329.90	80 / 80
ureter	0%	0	0 / 0	100%	382.07	1 / 1
blood vessel	99%	5235.47	1315 / 1335	0%	0	0 / 0
spleen	98%	3500.52	236 / 241	0%	0	0 / 0
adipose	96%	3063.78	1154 / 1204	0%	0	0 / 0
heart	93%	5094.84	798 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	219.58	39 / 45
lymph node	0%	0	0 / 0	55%	88.68	16 / 29
peripheral blood	2%	42.74	21 / 929	0%	0	0 / 0
muscle	1%	9.15	5 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0008625	Biological process	extrinsic apoptotic signaling pathway via death domain receptors
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0008656	Molecular function	cysteine-type endopeptidase activator activity involved in apoptotic process
GO_0042802	Molecular function	identical protein binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0005163	Molecular function	nerve growth factor receptor binding
GO_0046872	Molecular function	metal ion binding
GO_0140678	Molecular function	molecular function inhibitor activity

IV. Literature review

[source]

Gene name	BEX3
Protein name	Alternative protein NGFRAP1 Protein BEX3 (Brain-expressed X-linked protein 3) (Nerve growth factor receptor-associated protein 1) (Ovarian granulosa cell 13.0 kDa protein HGR74) (p75NTR-associated cell death executor)
Synonyms	DXS6984E NGFRAP1 NADE
Description	FUNCTION: May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. .
Accessions	Q14991 ENST00000372645.3 [Q00994-1] ENST00000361298.9 [Q00994-2] ENST00000372634.1 [Q00994-2] Q00994 ENST00000372635.1 [Q00994-1]

BEX3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review