DAXX report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903936Biological processcellular response to sodium arsenite
GO_0007254Biological processJNK cascade
GO_0010468Biological processregulation of gene expression
GO_0034620Biological processcellular response to unfolded protein
GO_0034605Biological processcellular response to heat
GO_0036480Biological processneuron intrinsic apoptotic signaling pathway in response to oxidative stress
GO_0010629Biological processnegative regulation of gene expression
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0071276Biological processcellular response to cadmium ion
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0006338Biological processchromatin remodeling
GO_0031396Biological processregulation of protein ubiquitination
GO_0006334Biological processnucleosome assembly
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0071280Biological processcellular response to copper ion
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0072738Biological processcellular response to diamide
GO_0030521Biological processandrogen receptor signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0000775Cellular componentchromosome, centromeric region
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0042393Molecular functionhistone binding
GO_0031072Molecular functionheat shock protein binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0019901Molecular functionprotein kinase binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0002039Molecular functionp53 binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDAXX
Protein nameDeath domain-associated protein 6 (Daxx)
Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)
Death domain associated protein
Death domain-associated protein 6
Death domain associated protein (Death domain-associated protein 6)
SynonymsBING2
DAP6
DescriptionFUNCTION: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Acts as a histone chaperone that facilitates deposition of histone H3.3. Acts as a targeting component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Does not affect the ATPase activity of ATRX but alleviates its transcription repression activity. Upon neuronal activation associates with regulatory elements of selected immediate early genes where it promotes deposition of histone H3.3 which may be linked to transcriptional induction of these genes. Required for the recruitment of histone H3.3:H4 dimers to PML-nuclear bodies (PML-NBs); the process is independent of ATRX and facilitated by ASF1A; PML-NBs are suggested to function as regulatory sites for the incorporation of newly synthesized histone H3.3 into chromatin. In case of overexpression of centromeric histone variant CENPA (as found in various tumors) is involved in its mislocalization to chromosomes; the ectopic localization involves a heterotypic tetramer containing CENPA, and histones H3.3 and H4 and decreases binding of CTCF to chromatin. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Shows restriction activity towards human cytomegalovirus (HCMV). Plays a role as a positive regulator of the heat shock transcription factor HSF1 activity during the stress protein response . .

AccessionsENST00000419051.1
ENST00000454197.1
ENST00000428268.1
ENST00000446403.1
ENST00000414272.5
B4E1C1
ENST00000374542.10 [Q9UER7-1]
ENST00000445009.6 [Q9UER7-1]
ENST00000616312.1 [Q9UER7-4]
ENST00000399060.7 [Q9UER7-1]
ENST00000453931.5
ENST00000421874.1
ENST00000419855.5
ENST00000451280.1
ENST00000612868.4 [Q9UER7-3]
ENST00000446511.1
A0A994J7Y1
ENST00000266000.10 [Q9UER7-1]
ENST00000399344.7 [Q9UER7-1]
ENST00000440500.1
ENST00000706094.1
ENST00000477162.1
A0A0G2JJZ4
ENST00000612888.2 [Q9UER7-3]
Q4VX54
ENST00000457553.1
ENST00000429531.1
ENST00000613912.3 [Q9UER7-4]
ENST00000617660.4 [Q9UER7-3]
Q9UER7
A2AB94
ENST00000619421.1 [Q9UER7-4]
ENST00000383062.8 [Q9UER7-1]
ENST00000622655.1 [Q9UER7-4]
ENST00000438332.5
ENST00000383194.8 [Q9UER7-1]
ENST00000414083.6 [Q9UER7-3]
ENST00000455860.6 [Q9UER7-1]
ENST00000620164.4 [Q9UER7-4]
ENST00000433482.5 [Q9UER7-1]
ENST00000436311.6 [Q9UER7-1]