GABARAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035020Biological processregulation of Rac protein signal transduction
GO_0000045Biological processautophagosome assembly
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0006605Biological processprotein targeting
GO_1902524Biological processpositive regulation of protein K48-linked ubiquitination
GO_0007268Biological processchemical synaptic transmission
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0000422Biological processautophagy of mitochondrion
GO_0015031Biological processprotein transport
GO_0097352Biological processautophagosome maturation
GO_0006995Biological processcellular response to nitrogen starvation
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005790Cellular componentsmooth endoplasmic reticulum
GO_0005764Cellular componentlysosome
GO_0000421Cellular componentautophagosome membrane
GO_0005930Cellular componentaxoneme
GO_0000139Cellular componentGolgi membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005776Cellular componentautophagosome
GO_0097225Cellular componentsperm midpiece
GO_0005875Cellular componentmicrotubule associated complex
GO_0048487Molecular functionbeta-tubulin binding
GO_0050811Molecular functionGABA receptor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008017Molecular functionmicrotubule binding
GO_0008429Molecular functionphosphatidylethanolamine binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGABARAP
Protein nameGamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46)
Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein)
GABA type A receptor-associated protein
SynonymsHT004
hCG_1987397
FLC3B
DescriptionFUNCTION: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton . Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation . Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover . Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction . Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation . Involved in apoptosis . .

AccessionsENST00000571129.5
ENST00000571253.1
ENST00000573928.1
H6UMI1
I3L3J4
O95166
I3L236
ENST00000570856.1
ENST00000577035.5
ENST00000302386.10
Q6IAW1