DIABLO report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DIABLO at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DIABLO at tissue level.

III. Associated gene sets

GO_0008635Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO_0006915Biological processapoptotic process
GO_0051402Biological processneuron apoptotic process
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0097193Biological processintrinsic apoptotic signaling pathway
GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0043065Biological processpositive regulation of apoptotic process
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0035631Cellular componentCD40 receptor complex
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDIABLO
Protein nameDirect IAP-binding protein with low pI (Second mitochondria-derived activator of caspase)
Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) [Cleaved into: Diablo IAP-binding mitochondrial protein, cleaved form]
Diablo IAP-binding mitochondrial protein
SynonymshCG_1782202
SMAC
DescriptionFUNCTION: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. .; FUNCTION: [Isoform 3]: Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. .; FUNCTION: [Isoform 1]: Defective in the capacity to down-regulate the XIAP/BIRC4 abundance. .

AccessionsH7BZQ7
Q9NR28
ENST00000541273.6
A0A2R8Y5H2
ENST00000342392.3
ENST00000353548.11 [Q9NR28-3]
A0A2U3TZH2
ENST00000443649.9
F5GYH3
ENST00000439489.6
ENST00000650715.1 [Q9NR28-1]
ENST00000541656.6
F5GXT8
F5GX50
ENST00000267169.11
ENST00000644227.1
ENST00000446652.5
Q502X2
ENST00000540535.6
A0A024RBT2
A0A0S2Z5U7
A0A0S2Z5P6
H7BZK7
ENST00000464942.7 [Q9NR28-1]
K7X1S0