SKIL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	26% ± 8%	Explore
macrophage	26 studies	25% ± 9%	Explore
fibroblast	23 studies	28% ± 8%	Explore
B cell	17 studies	27% ± 6%	Explore
conventional dendritic cell	16 studies	26% ± 8%	Explore
mast cell	15 studies	29% ± 7%	Explore
naive B cell	13 studies	26% ± 9%	Explore
microglial cell	12 studies	37% ± 13%	Explore
dendritic cell	11 studies	26% ± 12%	Explore
natural killer cell	11 studies	22% ± 5%	Explore
smooth muscle cell	11 studies	19% ± 4%	Explore
monocyte	10 studies	26% ± 9%	Explore
myofibroblast cell	10 studies	26% ± 7%	Explore
memory B cell	10 studies	27% ± 7%	Explore
classical monocyte	9 studies	25% ± 12%	Explore
non-classical monocyte	9 studies	28% ± 11%	Explore
capillary endothelial cell	9 studies	24% ± 6%	Explore
ciliated cell	9 studies	28% ± 14%	Explore
endothelial cell of artery	8 studies	28% ± 9%	Explore
basal cell	8 studies	22% ± 5%	Explore
vein endothelial cell	8 studies	23% ± 5%	Explore
type I pneumocyte	7 studies	23% ± 6%	Explore
neutrophil	7 studies	23% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	20% ± 4%	Explore
alveolar macrophage	7 studies	25% ± 11%	Explore
connective tissue cell	7 studies	24% ± 4%	Explore
pericyte	7 studies	23% ± 6%	Explore
T cell	6 studies	21% ± 7%	Explore
leukocyte	6 studies	30% ± 9%	Explore
CD8-positive, alpha-beta T cell	6 studies	17% ± 2%	Explore
myeloid cell	6 studies	32% ± 10%	Explore
epithelial cell	6 studies	39% ± 22%	Explore
gamma-delta T cell	6 studies	23% ± 11%	Explore
mature NK T cell	6 studies	19% ± 4%	Explore
neuron	5 studies	27% ± 9%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 4%	Explore
mucosal invariant T cell	5 studies	22% ± 11%	Explore
endothelial cell of vascular tree	5 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	24% ± 11%	Explore
astrocyte	5 studies	26% ± 4%	Explore
glutamatergic neuron	5 studies	48% ± 12%	Explore
goblet cell	5 studies	26% ± 7%	Explore
endothelial cell of lymphatic vessel	4 studies	19% ± 3%	Explore
mononuclear phagocyte	4 studies	27% ± 6%	Explore
abnormal cell	4 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	18% ± 2%	Explore
plasmacytoid dendritic cell	4 studies	35% ± 13%	Explore
innate lymphoid cell	4 studies	30% ± 11%	Explore
retinal cone cell	4 studies	31% ± 14%	Explore
GABAergic neuron	4 studies	30% ± 11%	Explore
oligodendrocyte precursor cell	4 studies	24% ± 8%	Explore
oligodendrocyte	4 studies	19% ± 3%	Explore
secretory cell	4 studies	28% ± 8%	Explore
glomerular endothelial cell	3 studies	25% ± 2%	Explore
precursor B cell	3 studies	26% ± 5%	Explore
squamous epithelial cell	3 studies	35% ± 23%	Explore
club cell	3 studies	26% ± 3%	Explore
retinal pigment epithelial cell	3 studies	28% ± 4%	Explore
retinal rod cell	3 studies	18% ± 4%	Explore
tissue-resident macrophage	3 studies	26% ± 9%	Explore
lymphocyte	3 studies	27% ± 7%	Explore
CD4-positive helper T cell	3 studies	25% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	28% ± 9%	Explore
regulatory T cell	3 studies	18% ± 1%	Explore
granulocyte	3 studies	34% ± 3%	Explore
neural progenitor cell	3 studies	18% ± 2%	Explore
adventitial cell	3 studies	28% ± 16%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 10%	Explore
interneuron	3 studies	27% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	24% ± 7%	Explore
brain	7 studies	33% ± 8%	Explore
peripheral blood	4 studies	25% ± 5%	Explore
kidney	3 studies	17% ± 1%	Explore
eye	3 studies	24% ± 3%	Explore
uterus	3 studies	26% ± 3%	Explore
intestine	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4681.78	578 / 578	100%	44.38	1150 / 1155
breast	100%	2354.89	459 / 459	99%	49.29	1112 / 1118
esophagus	100%	2058.15	1445 / 1445	99%	52.65	182 / 183
uterus	100%	2378.99	170 / 170	99%	48.47	456 / 459
ovary	100%	3043.02	180 / 180	98%	33.64	422 / 430
bladder	100%	2092.71	21 / 21	98%	39.23	493 / 504
brain	97%	1316.20	2555 / 2642	100%	21.59	703 / 705
thymus	100%	3559.19	653 / 653	96%	25.34	583 / 605
stomach	100%	1903.55	358 / 359	97%	38.26	276 / 286
prostate	100%	3041.90	245 / 245	96%	23.31	483 / 502
pancreas	97%	1095.39	317 / 328	98%	46.17	174 / 178
intestine	100%	2229.26	966 / 966	94%	32.07	497 / 527
kidney	100%	2173.35	89 / 89	90%	23.44	810 / 901
adrenal gland	100%	2223.14	258 / 258	84%	12.50	194 / 230
skin	100%	1969.05	1805 / 1809	70%	12.54	332 / 472
liver	100%	1849.30	225 / 226	66%	11.17	267 / 406
adipose	100%	2722.51	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3553.29	1335 / 1335	0%	0	0 / 0
muscle	100%	2150.82	803 / 803	0%	0	0 / 0
spleen	100%	1641.15	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.64	45 / 45
ureter	0%	0	0 / 0	100%	56.76	1 / 1
heart	97%	2125.70	835 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	20.98	26 / 29
peripheral blood	73%	889.31	677 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	3%	0.22	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1902231	Biological process	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0007283	Biological process	spermatogenesis
GO_0050772	Biological process	positive regulation of axonogenesis
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0034097	Biological process	response to cytokine
GO_0002260	Biological process	lymphocyte homeostasis
GO_0008625	Biological process	extrinsic apoptotic signaling pathway via death domain receptors
GO_1902043	Biological process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0008630	Biological process	intrinsic apoptotic signaling pathway in response to DNA damage
GO_0045596	Biological process	negative regulation of cell differentiation
GO_0070306	Biological process	lens fiber cell differentiation
GO_0001825	Biological process	blastocyst formation
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0051726	Biological process	regulation of cell cycle
GO_0001669	Cellular component	acrosomal vesicle
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005667	Cellular component	transcription regulator complex
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003682	Molecular function	chromatin binding
GO_0046332	Molecular function	SMAD binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SKIL
Protein name	SKI like proto-oncogene Ski-like protein (Ski-related oncogene) (Ski-related protein) Ski-like protein
Synonyms	SNO
Description	FUNCTION: May have regulatory role in cell division or differentiation in response to extracellular signals.
Accessions	ENST00000426052.6 [P12757-5] I6QMM9 ENST00000259119.9 [P12757-1] P12757 ENST00000465590.2 [P12757-1] C9J8R9 ENST00000476188.5 H7C4V3 ENST00000413427.6 [P12757-3] ENST00000458537.7 [P12757-1] ENST00000470571.1

SKIL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review