CASP10 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	10 studies	22% ± 5%	Explore
plasma cell	5 studies	33% ± 8%	Explore
macrophage	5 studies	22% ± 6%	Explore
epithelial cell	3 studies	27% ± 2%	Explore
endothelial cell of lymphatic vessel	3 studies	22% ± 0%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of CASP10 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	2878.38	578 / 578	99%	14.37	1148 / 1155
stomach	99%	1183.91	357 / 359	99%	17.05	284 / 286
thymus	100%	1368.59	651 / 653	99%	10.84	599 / 605
intestine	97%	1752.05	937 / 966	99%	16.49	523 / 527
kidney	100%	1371.16	89 / 89	95%	10.62	860 / 901
esophagus	99%	1145.58	1434 / 1445	96%	17.53	176 / 183
pancreas	99%	734.40	324 / 328	97%	12.92	172 / 178
liver	100%	817.46	226 / 226	93%	5.34	378 / 406
bladder	95%	887.52	20 / 21	93%	10.68	468 / 504
uterus	100%	882.51	170 / 170	88%	10.51	403 / 459
breast	100%	1617.41	459 / 459	87%	5.11	968 / 1118
skin	99%	940.51	1794 / 1809	71%	4.13	335 / 472
prostate	98%	958.86	241 / 245	67%	2.94	337 / 502
ovary	59%	303.05	106 / 180	91%	8.71	393 / 430
adrenal gland	96%	574.43	247 / 258	53%	2.21	123 / 230
brain	67%	310.09	1760 / 2642	70%	2.60	492 / 705
adipose	100%	2028.12	1204 / 1204	0%	0	0 / 0
spleen	100%	5519.60	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	3.21	1 / 1
peripheral blood	99%	2385.80	919 / 929	0%	0	0 / 0
heart	98%	743.93	848 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	10.97	44 / 45
lymph node	0%	0	0 / 0	79%	5.48	23 / 29
blood vessel	75%	500.13	996 / 1335	0%	0	0 / 0
muscle	64%	271.18	512 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	5%	0.19	4 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006915	Biological process	apoptotic process
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0008625	Biological process	extrinsic apoptotic signaling pathway via death domain receptors
GO_0030225	Biological process	macrophage differentiation
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0006508	Biological process	proteolysis
GO_0043525	Biological process	positive regulation of neuron apoptotic process
GO_0051604	Biological process	protein maturation
GO_0097342	Cellular component	ripoptosome
GO_0005829	Cellular component	cytosol
GO_0031265	Cellular component	CD95 death-inducing signaling complex
GO_0005737	Cellular component	cytoplasm
GO_0097153	Molecular function	cysteine-type endopeptidase activity involved in apoptotic process
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding
GO_0035877	Molecular function	death effector domain binding
GO_0097199	Molecular function	cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Gene name	CASP10
Protein name	Caspase 10 Caspase 10 apoptosis-related cysteine peptidase isoform 3 (Caspase 10, apoptosis-related cysteine peptidase, isoform CRA_d) Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12] Caspase 10 (cDNA FLJ61090, highly similar to Caspase-10) Caspase 10 apoptosis-related cysteine peptidase isoform 1
Synonyms	MCH4 hCG_16984
Description	FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-\|-AMC and Asp-Glu-Val-Asp-\|-AMC. .; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. .; FUNCTION: Isoform C is proteolytically inactive. .
Accessions	B4E3T5 A0A8Q3WLN0 ENST00000374650.8 [Q92851-7] A0A0S2Z3Z5 A0A0S2Z3G5 ENST00000313728.12 [Q92851-6] ENST00000492363.6 [Q92851-3] ENST00000286186.11 [Q92851-4] ENST00000696199.1 ENST00000438843.6 Q92851 A0A8Q3SJ84 ENST00000346817.10 [Q92851-2] ENST00000272879.9 [Q92851-1] ENST00000471191.2 ENST00000448480.1 [Q92851-5]

CASP10 report