RAF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0035994Biological processresponse to muscle stretch
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0038133Biological processERBB2-ERBB3 signaling pathway
GO_0042552Biological processmyelination
GO_0000165Biological processMAPK cascade
GO_0048011Biological processneurotrophin TRK receptor signaling pathway
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0060333Biological processtype II interferon-mediated signaling pathway
GO_0030878Biological processthyroid gland development
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0035773Biological processinsulin secretion involved in cellular response to glucose stimulus
GO_0042060Biological processwound healing
GO_0071550Biological processdeath-inducing signaling complex assembly
GO_0007190Biological processactivation of adenylate cyclase activity
GO_0008286Biological processinsulin receptor signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0014044Biological processSchwann cell development
GO_0045595Biological processregulation of cell differentiation
GO_0060324Biological processface development
GO_0035023Biological processregulation of Rho protein signal transduction
GO_0045104Biological processintermediate filament cytoskeleton organization
GO_0048538Biological processthymus development
GO_2000145Biological processregulation of cell motility
GO_0006915Biological processapoptotic process
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0006468Biological processprotein phosphorylation
GO_0044342Biological processtype B pancreatic cell proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035019Biological processsomatic stem cell population maintenance
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031143Cellular componentpseudopodium
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0004672Molecular functionprotein kinase activity
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRAF1
Protein nameEosinophil cationic protein (Ribonuclease 3)
Raf-1 proto-oncogene, serine/threonine kinase
non-specific serine/threonine protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (Raf-1)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
SynonymshCG_40478
RAF
RNASE3
DescriptionFUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. .

AccessionsA0A8I5KSV6
ENST00000691899.1 [P04049-1]
ENST00000685653.1 [P04049-1]
ENST00000690585.1
ENST00000685437.1
A0A8I5KSI1
ENST00000685738.1
ENST00000687326.1
ENST00000692959.1
ENST00000432427.3
A0A8I5KQV4
A0A8I5KW44
A0A8I5KS16
ENST00000692093.1
ENST00000686762.1
A0A8I5KUW4
ENST00000689033.1
ENST00000689481.1
ENST00000423275.6
A0A8I5QKU8
ENST00000691724.1
ENST00000416093.2
A0A8I5KTA5
A0A0S2Z559
ENST00000693705.1
A0A8I5QKZ6
ENST00000691396.1
ENST00000689914.1
ENST00000685348.1
ENST00000690397.1
A0A8I5KX50
ENST00000691718.1
A0A8I5KT32
A0A8I5KR46
A0A8I5KYC4
A0A0S2Z4L5
ENST00000687486.1
A0A8I5QJG5
ENST00000442415.7 [P04049-2]
A0A8I5KTK4
ENST00000690460.1
ENST00000688543.1
ENST00000251849.9 [P04049-1]
A0A8I5KSB0
ENST00000687923.1
W0UUR6
ENST00000691779.1
A0A0B4J1W9
A0A8I5KWF7
A0A8I5KSM4
ENST00000688625.1
ENST00000689876.1
A0A8I5KWS9
ENST00000689097.1
ENST00000689226.1
ENST00000693069.1
ENST00000693312.1
ENST00000691268.1
ENST00000688326.1
H7C155
ENST00000688753.1
A0A8I5KYP5
ENST00000693664.1
P04049
ENST00000684903.1
ENST00000689389.1
ENST00000687348.1
ENST00000691888.1
ENST00000685959.1
A0A8I5KQ33
A0A8I5KRD1
A0A8I5KWA9
ENST00000685740.1
ENST00000689418.1
ENST00000692773.1
ENST00000692830.1
L7RRS6