Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | NRG1-ERBB3 | NRG1_HUMAN - ERBB3_HUMAN | Ligand-Receptor | Signaling by Neuregulin |
| Name | ERBB2-ERBB3 signaling pathway |
| ID | GO_0038133 |
| collection_id | Biological process |
| Exact synonym | ERBB2-ERBB3 signalling pathway, HER2-HER3 signaling pathway |
| Description | The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission. |
| External URL | |
| Genes |