Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 24 studies | 28% ± 11% | |
classical monocyte | 17 studies | 26% ± 8% | |
dendritic cell | 15 studies | 32% ± 13% | |
endothelial cell | 15 studies | 28% ± 9% | |
monocyte | 12 studies | 29% ± 13% | |
non-classical monocyte | 12 studies | 25% ± 8% | |
conventional dendritic cell | 11 studies | 29% ± 13% | |
myeloid cell | 11 studies | 30% ± 8% | |
glutamatergic neuron | 10 studies | 41% ± 20% | |
microglial cell | 10 studies | 31% ± 11% | |
fibroblast | 9 studies | 21% ± 6% | |
adipocyte | 8 studies | 28% ± 6% | |
GABAergic neuron | 7 studies | 34% ± 18% | |
natural killer cell | 7 studies | 17% ± 3% | |
T cell | 7 studies | 18% ± 2% | |
CD4-positive, alpha-beta T cell | 7 studies | 19% ± 2% | |
astrocyte | 7 studies | 28% ± 9% | |
plasmacytoid dendritic cell | 6 studies | 26% ± 6% | |
pericyte | 6 studies | 22% ± 4% | |
epithelial cell | 5 studies | 30% ± 8% | |
mononuclear phagocyte | 5 studies | 36% ± 4% | |
type II pneumocyte | 5 studies | 20% ± 3% | |
neuron | 4 studies | 31% ± 8% | |
lymphocyte | 4 studies | 24% ± 7% | |
Mueller cell | 4 studies | 19% ± 4% | |
hepatocyte | 4 studies | 37% ± 20% | |
oligodendrocyte precursor cell | 4 studies | 25% ± 6% | |
CD8-positive, alpha-beta T cell | 4 studies | 17% ± 1% | |
alveolar macrophage | 4 studies | 34% ± 13% | |
interneuron | 4 studies | 35% ± 17% | |
oligodendrocyte | 4 studies | 22% ± 6% | |
squamous epithelial cell | 3 studies | 33% ± 14% | |
mature NK T cell | 3 studies | 18% ± 5% | |
innate lymphoid cell | 3 studies | 26% ± 7% | |
type I pneumocyte | 3 studies | 20% ± 0% | |
abnormal cell | 3 studies | 21% ± 7% | |
leukocyte | 3 studies | 22% ± 2% | |
B cell | 3 studies | 19% ± 4% | |
endothelial cell of lymphatic vessel | 3 studies | 19% ± 2% | |
group 3 innate lymphoid cell | 3 studies | 24% ± 7% | |
basal cell | 3 studies | 23% ± 6% | |
connective tissue cell | 3 studies | 21% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 100% | 2267.84 | 966 / 966 | 100% | 48.98 | 527 / 527 |
ovary | 100% | 2120.28 | 180 / 180 | 100% | 35.23 | 430 / 430 |
stomach | 100% | 1708.65 | 359 / 359 | 100% | 45.10 | 286 / 286 |
esophagus | 100% | 2796.71 | 1444 / 1445 | 100% | 55.90 | 183 / 183 |
lung | 100% | 3068.11 | 577 / 578 | 100% | 61.82 | 1155 / 1155 |
brain | 100% | 5219.76 | 2632 / 2642 | 100% | 75.82 | 705 / 705 |
prostate | 100% | 2151.18 | 244 / 245 | 100% | 70.67 | 502 / 502 |
breast | 100% | 2883.39 | 459 / 459 | 100% | 47.05 | 1113 / 1118 |
bladder | 100% | 2399.62 | 21 / 21 | 99% | 50.55 | 501 / 504 |
uterus | 100% | 2378.88 | 170 / 170 | 99% | 63.17 | 456 / 459 |
thymus | 100% | 1907.12 | 652 / 653 | 99% | 42.77 | 600 / 605 |
kidney | 100% | 2166.36 | 89 / 89 | 99% | 50.62 | 892 / 901 |
skin | 100% | 2480.77 | 1805 / 1809 | 99% | 53.50 | 468 / 472 |
liver | 100% | 2838.62 | 226 / 226 | 98% | 30.86 | 398 / 406 |
adrenal gland | 100% | 2624.25 | 258 / 258 | 97% | 56.41 | 224 / 230 |
pancreas | 95% | 1103.25 | 311 / 328 | 98% | 52.16 | 175 / 178 |
adipose | 100% | 3830.51 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 66.06 | 29 / 29 |
muscle | 100% | 4292.28 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2643.76 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 64.02 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 42.24 | 1 / 1 |
blood vessel | 100% | 3388.59 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 3419.64 | 890 / 929 | 0% | 0 | 0 / 0 |
heart | 94% | 2276.65 | 808 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 86% | 18.63 | 69 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_2000641 | Biological process | regulation of early endosome to late endosome transport |
GO_0030216 | Biological process | keratinocyte differentiation |
GO_0048870 | Biological process | cell motility |
GO_0038133 | Biological process | ERBB2-ERBB3 signaling pathway |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0060020 | Biological process | Bergmann glial cell differentiation |
GO_0050772 | Biological process | positive regulation of axonogenesis |
GO_0042552 | Biological process | myelination |
GO_0000165 | Biological process | MAPK cascade |
GO_0007507 | Biological process | heart development |
GO_0048009 | Biological process | insulin-like growth factor receptor signaling pathway |
GO_0007165 | Biological process | signal transduction |
GO_0090170 | Biological process | regulation of Golgi inheritance |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0035987 | Biological process | endodermal cell differentiation |
GO_0030878 | Biological process | thyroid gland development |
GO_0006935 | Biological process | chemotaxis |
GO_0032872 | Biological process | regulation of stress-activated MAPK cascade |
GO_0048679 | Biological process | regulation of axon regeneration |
GO_0060440 | Biological process | trachea formation |
GO_0030182 | Biological process | neuron differentiation |
GO_0070371 | Biological process | ERK1 and ERK2 cascade |
GO_0014044 | Biological process | Schwann cell development |
GO_0060711 | Biological process | labyrinthine layer development |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0060674 | Biological process | placenta blood vessel development |
GO_0060324 | Biological process | face development |
GO_0048538 | Biological process | thymus development |
GO_0021697 | Biological process | cerebellar cortex formation |
GO_0090398 | Biological process | cellular senescence |
GO_1903226 | Biological process | positive regulation of endodermal cell differentiation |
GO_0044342 | Biological process | type B pancreatic cell proliferation |
GO_0060502 | Biological process | epithelial cell proliferation involved in lung morphogenesis |
GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
GO_0071902 | Biological process | positive regulation of protein serine/threonine kinase activity |
GO_0005886 | Cellular component | plasma membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0005769 | Cellular component | early endosome |
GO_0005813 | Cellular component | centrosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005925 | Cellular component | focal adhesion |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005770 | Cellular component | late endosome |
GO_0005634 | Cellular component | nucleus |
GO_0004712 | Molecular function | protein serine/threonine/tyrosine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005078 | Molecular function | MAP-kinase scaffold activity |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0004708 | Molecular function | MAP kinase kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0004672 | Molecular function | protein kinase activity |
GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
GO_0030295 | Molecular function | protein kinase activator activity |
GO_0097110 | Molecular function | scaffold protein binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MAP2K1 |
Protein name | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) |
Synonyms | PRKMK1 MEK1 hCG_24510 |
Description | FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation . Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. . |
Accessions | ENST00000691576.1 A0A8I5QJ96 Q02750 A0A8I5QJC1 A0A8I5KYB4 A0A8I5QJP8 A0A8I5KYS7 ENST00000684779.1 ENST00000692683.1 ENST00000686347.1 ENST00000307102.10 [Q02750-1] ENST00000685763.1 H3BRW9 A0A8I5KVF6 ENST00000689951.1 ENST00000691077.1 A0A8I5QJL9 ENST00000566326.1 ENST00000693150.1 A0A8I5KRX5 ENST00000691937.1 B4DFY5 ENST00000692487.1 A0A8I5KXN4 A4QPA9 ENST00000685172.1 |