MAP2K1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000641Biological processregulation of early endosome to late endosome transport
GO_0030216Biological processkeratinocyte differentiation
GO_0048870Biological processcell motility
GO_0038133Biological processERBB2-ERBB3 signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0060020Biological processBergmann glial cell differentiation
GO_0050772Biological processpositive regulation of axonogenesis
GO_0042552Biological processmyelination
GO_0000165Biological processMAPK cascade
GO_0007507Biological processheart development
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0090170Biological processregulation of Golgi inheritance
GO_0010628Biological processpositive regulation of gene expression
GO_0035987Biological processendodermal cell differentiation
GO_0030878Biological processthyroid gland development
GO_0006935Biological processchemotaxis
GO_0032872Biological processregulation of stress-activated MAPK cascade
GO_0048679Biological processregulation of axon regeneration
GO_0060440Biological processtrachea formation
GO_0030182Biological processneuron differentiation
GO_0070371Biological processERK1 and ERK2 cascade
GO_0014044Biological processSchwann cell development
GO_0060711Biological processlabyrinthine layer development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0060674Biological processplacenta blood vessel development
GO_0060324Biological processface development
GO_0048538Biological processthymus development
GO_0021697Biological processcerebellar cortex formation
GO_0090398Biological processcellular senescence
GO_1903226Biological processpositive regulation of endodermal cell differentiation
GO_0044342Biological processtype B pancreatic cell proliferation
GO_0060502Biological processepithelial cell proliferation involved in lung morphogenesis
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0005813Cellular componentcentrosome
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0005634Cellular componentnucleus
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005078Molecular functionMAP-kinase scaffold activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004708Molecular functionMAP kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0030295Molecular functionprotein kinase activator activity
GO_0097110Molecular functionscaffold protein binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP2K1
Protein nameDual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1)
SynonymsPRKMK1
MEK1
hCG_24510
DescriptionFUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation . Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. .

AccessionsENST00000691576.1
A0A8I5QJ96
Q02750
A0A8I5QJC1
A0A8I5KYB4
A0A8I5QJP8
A0A8I5KYS7
ENST00000684779.1
ENST00000692683.1
ENST00000686347.1
ENST00000307102.10 [Q02750-1]
ENST00000685763.1
H3BRW9
A0A8I5KVF6
ENST00000689951.1
ENST00000691077.1
A0A8I5QJL9
ENST00000566326.1
ENST00000693150.1
A0A8I5KRX5
ENST00000691937.1
B4DFY5
ENST00000692487.1
A0A8I5KXN4
A4QPA9
ENST00000685172.1