MAP2K2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000641Biological processregulation of early endosome to late endosome transport
GO_0038133Biological processERBB2-ERBB3 signaling pathway
GO_0050772Biological processpositive regulation of axonogenesis
GO_0042552Biological processmyelination
GO_0000165Biological processMAPK cascade
GO_0007507Biological processheart development
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0090170Biological processregulation of Golgi inheritance
GO_0010628Biological processpositive regulation of gene expression
GO_2000147Biological processpositive regulation of cell motility
GO_0030878Biological processthyroid gland development
GO_0032872Biological processregulation of stress-activated MAPK cascade
GO_0048679Biological processregulation of axon regeneration
GO_0060440Biological processtrachea formation
GO_0070371Biological processERK1 and ERK2 cascade
GO_0014044Biological processSchwann cell development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0060324Biological processface development
GO_0048538Biological processthymus development
GO_0036289Biological processpeptidyl-serine autophosphorylation
GO_0060502Biological processepithelial cell proliferation involved in lung morphogenesis
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0005778Cellular componentperoxisomal membrane
GO_0005576Cellular componentextracellular region
GO_0005874Cellular componentmicrotubule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0005911Cellular componentcell-cell junction
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0005634Cellular componentnucleus
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005078Molecular functionMAP-kinase scaffold activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004708Molecular functionMAP kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0030165Molecular functionPDZ domain binding
GO_0097110Molecular functionscaffold protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP2K2
Protein namemitogen-activated protein kinase kinase (EC 2.7.12.2)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
SynonymsMKK2
MEK2
hCG_23544
PRKMK2
DescriptionFUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation . .

AccessionsP36507
M0R1B6
B3KS97
ENST00000599021.1
ENST00000262948.10