ERBB3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	14 studies	39% ± 17%	Explore
epithelial cell	12 studies	40% ± 16%	Explore
type I pneumocyte	10 studies	28% ± 9%	Explore
ciliated cell	8 studies	26% ± 9%	Explore
goblet cell	8 studies	29% ± 9%	Explore
oligodendrocyte precursor cell	8 studies	36% ± 13%	Explore
club cell	7 studies	31% ± 13%	Explore
respiratory goblet cell	7 studies	27% ± 11%	Explore
basal cell	6 studies	27% ± 12%	Explore
secretory cell	6 studies	25% ± 7%	Explore
enterocyte	6 studies	28% ± 8%	Explore
squamous epithelial cell	4 studies	43% ± 22%	Explore
enteroendocrine cell	4 studies	30% ± 6%	Explore
intestinal crypt stem cell	4 studies	24% ± 5%	Explore
progenitor cell	4 studies	27% ± 8%	Explore
Schwann cell	4 studies	42% ± 18%	Explore
type II pneumocyte	4 studies	22% ± 8%	Explore
glial cell	4 studies	41% ± 19%	Explore
hepatocyte	4 studies	30% ± 23%	Explore
brush cell	4 studies	28% ± 3%	Explore
ionocyte	3 studies	17% ± 1%	Explore
transit amplifying cell	3 studies	24% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	26% ± 7%	Explore
melanocyte	3 studies	27% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	29% ± 9%	Explore
abnormal cell	3 studies	24% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	4 studies	19% ± 4%	Explore
lung	3 studies	25% ± 7%	Explore
brain	3 studies	35% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	8729.63	226 / 226	96%	80.54	389 / 406
prostate	96%	7072.05	235 / 245	99%	120.10	497 / 502
stomach	95%	9527.83	340 / 359	98%	128.23	280 / 286
intestine	94%	8695.37	908 / 966	98%	127.88	517 / 527
pancreas	100%	6124.96	328 / 328	92%	86.92	163 / 178
esophagus	94%	6666.59	1356 / 1445	90%	85.78	165 / 183
kidney	99%	5060.07	88 / 89	84%	73.98	754 / 901
skin	72%	10001.37	1305 / 1809	94%	226.44	445 / 472
lung	81%	3394.93	467 / 578	85%	71.68	985 / 1155
breast	61%	5458.16	278 / 459	99%	166.78	1104 / 1118
bladder	67%	3608.33	14 / 21	90%	85.08	454 / 504
thymus	63%	1463.63	410 / 653	59%	26.39	355 / 605
brain	68%	3260.90	1793 / 2642	32%	15.19	227 / 705
ureter	0%	0	0 / 0	100%	30.42	1 / 1
uterus	12%	372.33	20 / 170	81%	56.33	374 / 459
eye	0%	0	0 / 0	86%	71.35	69 / 80
ovary	1%	30.54	2 / 180	84%	49.19	363 / 430
tonsil	0%	0	0 / 0	82%	41.79	37 / 45
heart	19%	412.22	160 / 861	0%	0	0 / 0
blood vessel	5%	171.49	71 / 1335	0%	0	0 / 0
adipose	5%	129.05	59 / 1204	0%	0	0 / 0
muscle	4%	85.34	30 / 803	0%	0	0 / 0
adrenal gland	2%	46.84	5 / 258	1%	1.08	3 / 230
spleen	0%	12.59	1 / 241	0%	0	0 / 0
peripheral blood	0%	1.59	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0038133	Biological process	ERBB2-ERBB3 signaling pathway
GO_0014037	Biological process	Schwann cell differentiation
GO_0055025	Biological process	positive regulation of cardiac muscle tissue development
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0042552	Biological process	myelination
GO_0007507	Biological process	heart development
GO_0009968	Biological process	negative regulation of signal transduction
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0070886	Biological process	positive regulation of calcineurin-NFAT signaling cascade
GO_0007275	Biological process	multicellular organism development
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0042060	Biological process	wound healing
GO_0033674	Biological process	positive regulation of kinase activity
GO_0051402	Biological process	neuron apoptotic process
GO_0022008	Biological process	neurogenesis
GO_0014044	Biological process	Schwann cell development
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0097192	Biological process	extrinsic apoptotic signaling pathway in absence of ligand
GO_0007422	Biological process	peripheral nervous system development
GO_0003197	Biological process	endocardial cushion development
GO_0043491	Biological process	phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_2000672	Biological process	negative regulation of motor neuron apoptotic process
GO_0097049	Biological process	motor neuron apoptotic process
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0051048	Biological process	negative regulation of secretion
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0021545	Biological process	cranial nerve development
GO_0042127	Biological process	regulation of cell population proliferation
GO_0016324	Cellular component	apical plasma membrane
GO_0005615	Cellular component	extracellular space
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0009925	Cellular component	basal plasma membrane
GO_0038143	Cellular component	ERBB3:ERBB2 complex
GO_0016328	Cellular component	lateral plasma membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0038131	Molecular function	neuregulin receptor activity
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0042802	Molecular function	identical protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0030296	Molecular function	protein tyrosine kinase activator activity
GO_0019838	Molecular function	growth factor binding
GO_0043125	Molecular function	ErbB-3 class receptor binding
GO_0005524	Molecular function	ATP binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0038132	Molecular function	neuregulin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ERBB3
Protein name	Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3) Erb-b2 receptor tyrosine kinase 3 (ErbB-3 R31) receptor protein-tyrosine kinase (EC 2.7.10.1) Erb-b2 receptor tyrosine kinase 3 Erb-b2 receptor tyrosine kinase 3 (cDNA FLJ43038 fis, clone BRTHA3002955, highly similar to Receptor tyrosine-protein kinase erbB-3)
Synonyms	HER3 c-erbB-3
Description	FUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase . May also be activated by CSPG5 . Involved in the regulation of myeloid cell differentiation . .
Accessions	ENST00000683164.1 [P21860-4] F8VRL0 O75812 F8VW48 P21860 ENST00000267101.8 [P21860-1] F8VRI5 ENST00000411731.6 [P21860-2] ENST00000550828.1 ENST00000549061.5 ENST00000683059.1 [P21860-4] B4DGQ7 A0A2R8Y6T4 ENST00000683018.1 [P21860-4] ENST00000549282.5 ENST00000550869.5 B3KWG5 ENST00000549832.1 F8VYK4 ENST00000415288.6 [P21860-4] ENST00000551085.5 ENST00000643266.1 ENST00000550070.6 ENST00000551242.5 [P21860-3]

ERBB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review