NRG1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	70% ± 14%	Explore
GABAergic neuron	9 studies	46% ± 22%	Explore
classical monocyte	7 studies	20% ± 3%	Explore
endothelial cell	7 studies	36% ± 17%	Explore
neuron	6 studies	38% ± 18%	Explore
interneuron	6 studies	43% ± 16%	Explore
retinal ganglion cell	6 studies	66% ± 32%	Explore
microglial cell	5 studies	36% ± 22%	Explore
basal cell	5 studies	33% ± 21%	Explore
type I pneumocyte	5 studies	41% ± 7%	Explore
astrocyte	5 studies	32% ± 27%	Explore
cholangiocyte	4 studies	44% ± 22%	Explore
hepatocyte	4 studies	54% ± 30%	Explore
granule cell	4 studies	57% ± 9%	Explore
retina horizontal cell	4 studies	89% ± 12%	Explore
retinal cone cell	4 studies	70% ± 20%	Explore
GABAergic interneuron	3 studies	39% ± 16%	Explore
epithelial cell	3 studies	17% ± 1%	Explore
oligodendrocyte precursor cell	3 studies	19% ± 1%	Explore
GABAergic amacrine cell	3 studies	56% ± 6%	Explore
OFF-bipolar cell	3 studies	88% ± 5%	Explore
ON-bipolar cell	3 studies	70% ± 7%	Explore
amacrine cell	3 studies	35% ± 12%	Explore
retinal rod cell	3 studies	53% ± 32%	Explore
oligodendrocyte	3 studies	40% ± 29%	Explore
myoepithelial cell	3 studies	31% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	43% ± 19%	Explore
eye	5 studies	35% ± 16%	Explore
liver	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	545.07	89 / 89	70%	2.66	630 / 901
thymus	99%	1144.25	647 / 653	55%	1.83	332 / 605
lung	98%	504.49	567 / 578	39%	1.62	453 / 1155
liver	88%	656.62	200 / 226	24%	0.67	98 / 406
esophagus	42%	137.12	602 / 1445	69%	5.01	127 / 183
prostate	95%	469.60	232 / 245	12%	0.18	58 / 502
skin	98%	832.25	1766 / 1809	6%	0.16	30 / 472
brain	75%	313.52	1993 / 2642	21%	0.49	147 / 705
adrenal gland	38%	80.53	99 / 258	55%	2.49	126 / 230
breast	61%	842.05	281 / 459	29%	0.89	319 / 1118
intestine	73%	343.00	701 / 966	15%	0.30	78 / 527
bladder	62%	532.19	13 / 21	22%	1.32	110 / 504
ovary	68%	182.16	122 / 180	12%	0.32	50 / 430
spleen	75%	136.22	180 / 241	0%	0	0 / 0
uterus	37%	256.12	63 / 170	33%	1.23	151 / 459
tonsil	0%	0	0 / 0	69%	3.12	31 / 45
stomach	47%	157.91	168 / 359	21%	0.63	59 / 286
peripheral blood	53%	165.12	489 / 929	0%	0	0 / 0
heart	42%	126.00	358 / 861	0%	0	0 / 0
blood vessel	34%	88.94	448 / 1335	0%	0	0 / 0
pancreas	2%	2.89	8 / 328	8%	0.27	15 / 178
adipose	6%	11.39	75 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
muscle	0%	0.13	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030879	Biological process	mammary gland development
GO_0038133	Biological process	ERBB2-ERBB3 signaling pathway
GO_0032148	Biological process	activation of protein kinase B activity
GO_0007171	Biological process	activation of transmembrane receptor protein tyrosine kinase activity
GO_0055007	Biological process	cardiac muscle cell differentiation
GO_0038127	Biological process	ERBB signaling pathway
GO_0014032	Biological process	neural crest cell development
GO_0048513	Biological process	animal organ development
GO_0050919	Biological process	negative chemotaxis
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0042060	Biological process	wound healing
GO_0060956	Biological process	endocardial cell differentiation
GO_0038138	Biological process	ERBB4-ERBB4 signaling pathway
GO_0035556	Biological process	intracellular signal transduction
GO_0030154	Biological process	cell differentiation
GO_0060379	Biological process	cardiac muscle cell myoblast differentiation
GO_0099149	Biological process	regulation of postsynaptic neurotransmitter receptor internalization
GO_0007154	Biological process	cell communication
GO_0051155	Biological process	positive regulation of striated muscle cell differentiation
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0051048	Biological process	negative regulation of secretion
GO_0038135	Biological process	ERBB2-ERBB4 signaling pathway
GO_0003222	Biological process	ventricular trabecula myocardium morphogenesis
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0038129	Biological process	ERBB3 signaling pathway
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0007399	Biological process	nervous system development
GO_0038130	Biological process	ERBB4 signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0098978	Cellular component	glutamatergic synapse
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0048018	Molecular function	receptor ligand activity
GO_0003712	Molecular function	transcription coregulator activity
GO_0005178	Molecular function	integrin binding
GO_0008083	Molecular function	growth factor activity
GO_0030296	Molecular function	protein tyrosine kinase activator activity
GO_0043125	Molecular function	ErbB-3 class receptor binding
GO_0045499	Molecular function	chemorepellent activity
GO_0030297	Molecular function	transmembrane receptor protein tyrosine kinase activator activity
GO_0030971	Molecular function	receptor tyrosine kinase binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	NRG1
Protein name	Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)] Neuregulin 1 Neuregulin 1 isoform HRG-beta3 (Neuregulin 1, isoform CRA_g) NRG1 protein Neuregulin 1 variant fetal a IV 1 Neuregulin 1 isoform HRG-gamma Neuregulin 1 variant fetal b IV-beta 1a Neuregulin 1 variant fetal c IV 2 Heregulin-gamma protein isoform 2 Heregulin-gamma protein isoform 1 Neuregulin 1 isoform 4 Heregulin-beta 3 protein isoform Neuregulin 1 isoform HRG-gamma (Neuregulin 1, isoform CRA_l) Neuregulin 1 type IV beta 3 Neuregulin 1 isoform HRG-alpha (Neuregulin 1 isoform HRG-beta1) (Neuregulin 1 isoform HRG-beta2) (Neuregulin 1 isoform HRG-beta3) (Neuregulin 1 isoform HRG-gamma) (Neuregulin 1 isoform ndf43) Pro-neuregulin-1, membrane-bound isoform
Synonyms	GGF hCG_14780 HRGA HGL NDF SMDF
Description	FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 . Binds to ERBB3 . Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 . Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). .
Accessions	A0A494C054 Q86WJ0 ENST00000523041.2 H0YDC2 B9EK51 B0FYA8 ENST00000287842.7 [Q02297-6] A5YAK7 A0A494C043 Q7RTW4 A0A494C0T5 Q7RTW5 A6MW56 ENST00000520407.5 [Q02297-9] H0YBA3 ENST00000652588.1 ENST00000652698.1 E3SFN0 H0YCP0 ENST00000522402.6 B0FYA9 A0A494C0K4 ENST00000652592.1 ENST00000405005.8 [Q02297-1] ENST00000650819.1 A0A494C0L9 A0A494C1F5 ENST00000518084.5 B5BU95 A0A494C1F8 A0A494C0Q4 ENST00000522569.1 ENST00000519301.6 [Q02297-11] Q7RTW3 A6MW54 ENST00000521670.5 [Q02297-3] ENST00000651149.1 Q02297 ENST00000356819.7 [Q02297-7] A0A5F9ZHA5 A0A494C114 ENST00000651333.2 ENST00000650866.1 Q96IB3 ENST00000523534.5 A0A024QY88 E5RIG8 ENST00000651335.1 ENST00000523079.5 [Q02297-12] A5YAK8 A0A494C1B5 A0A494BZT4 B0FYA7 B0FWZ3 E5RHP6 B7Z168 E3SFM9 ENST00000520502.7 [Q02297-10] ENST00000519240.5 Q6ICV5 ENST00000650980.1 Q7RTV8 ENST00000650856.1 E5RHQ1 A0A494C1G2 ENST00000518206.5 A6MW55 ENST00000650919.1 [Q02297-8] Q6PK61 ENST00000650967.1 A5YAK6 ENST00000651696.1

NRG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review