MAPK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0120041Biological processpositive regulation of macrophage proliferation
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0043330Biological processresponse to exogenous dsRNA
GO_0038127Biological processERBB signaling pathway
GO_0030878Biological processthyroid gland development
GO_0006935Biological processchemotaxis
GO_0032872Biological processregulation of stress-activated MAPK cascade
GO_0019858Biological processcytosine metabolic process
GO_0035094Biological processresponse to nicotine
GO_0006468Biological processprotein phosphorylation
GO_0007166Biological processcell surface receptor signaling pathway
GO_0042473Biological processouter ear morphogenesis
GO_0038133Biological processERBB2-ERBB3 signaling pathway
GO_1904355Biological processpositive regulation of telomere capping
GO_0042552Biological processmyelination
GO_0072584Biological processcaveolin-mediated endocytosis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0090170Biological processregulation of Golgi inheritance
GO_0071276Biological processcellular response to cadmium ion
GO_0060291Biological processlong-term synaptic potentiation
GO_0050852Biological processT cell receptor signaling pathway
GO_0051403Biological processstress-activated MAPK cascade
GO_0070371Biological processERK1 and ERK2 cascade
GO_0060425Biological processlung morphogenesis
GO_0060324Biological processface development
GO_0060716Biological processlabyrinthine layer blood vessel development
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0030521Biological processandrogen receptor signaling pathway
GO_0070849Biological processresponse to epidermal growth factor
GO_0033598Biological processmammary gland epithelial cell proliferation
GO_0051493Biological processregulation of cytoskeleton organization
GO_0050853Biological processB cell receptor signaling pathway
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0050847Biological processprogesterone receptor signaling pathway
GO_0060440Biological processtrachea formation
GO_0008286Biological processinsulin receptor signaling pathway
GO_0007268Biological processchemical synaptic transmission
GO_0048538Biological processthymus development
GO_0051973Biological processpositive regulation of telomerase activity
GO_0061308Biological processcardiac neural crest cell development involved in heart development
GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_2000641Biological processregulation of early endosome to late endosome transport
GO_0034614Biological processcellular response to reactive oxygen species
GO_0060020Biological processBergmann glial cell differentiation
GO_0007611Biological processlearning or memory
GO_0006974Biological processDNA damage response
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0035556Biological processintracellular signal transduction
GO_0014044Biological processSchwann cell development
GO_0034198Biological processcellular response to amino acid starvation
GO_0006915Biological processapoptotic process
GO_0045596Biological processnegative regulation of cell differentiation
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0030278Biological processregulation of ossification
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0030641Biological processregulation of cellular pH
GO_0031647Biological processregulation of protein stability
GO_0035578Cellular componentazurophil granule lumen
GO_0005856Cellular componentcytoskeleton
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005634Cellular componentnucleus
GO_0005576Cellular componentextracellular region
GO_0072686Cellular componentmitotic spindle
GO_0005654Cellular componentnucleoplasm
GO_0005770Cellular componentlate endosome
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0005813Cellular componentcentrosome
GO_0005794Cellular componentGolgi apparatus
GO_0005737Cellular componentcytoplasm
GO_0005901Cellular componentcaveola
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0031143Cellular componentpseudopodium
GO_0042802Molecular functionidentical protein binding
GO_0008353Molecular functionRNA polymerase II CTD heptapeptide repeat kinase activity
GO_0005524Molecular functionATP binding
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0004707Molecular functionMAP kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0019902Molecular functionphosphatase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding

IV. Literature review

[source]
Gene nameMAPK1
Protein nameMitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Mitogen-activated protein kinase (EC 2.7.11.24)
SynonymsPRKM1
PRKM2
hCG_32557
ERK2
DescriptionFUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity). .; FUNCTION: Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. .

AccessionsENST00000215832.11 [P28482-1]
P28482
Q499G7
ENST00000398822.7 [P28482-1]
Q1HBJ4
ENST00000544786.1 [P28482-2]