ERBB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0038133Biological processERBB2-ERBB3 signaling pathway
GO_0032886Biological processregulation of microtubule-based process
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0042552Biological processmyelination
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0030307Biological processpositive regulation of cell growth
GO_0007507Biological processheart development
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0007165Biological processsignal transduction
GO_0007167Biological processenzyme-linked receptor protein signaling pathway
GO_0007275Biological processmulticellular organism development
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0045785Biological processpositive regulation of cell adhesion
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0071363Biological processcellular response to growth factor stimulus
GO_0007528Biological processneuromuscular junction development
GO_0045765Biological processregulation of angiogenesis
GO_0042060Biological processwound healing
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0033674Biological processpositive regulation of kinase activity
GO_0030182Biological processneuron differentiation
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0022008Biological processneurogenesis
GO_0035556Biological processintracellular signal transduction
GO_0014044Biological processSchwann cell development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0038134Biological processERBB2-EGFR signaling pathway
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_0045727Biological processpositive regulation of translation
GO_0048709Biological processoligodendrocyte differentiation
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0008045Biological processmotor neuron axon guidance
GO_0033088Biological processnegative regulation of immature T cell proliferation in thymus
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0038135Biological processERBB2-ERBB4 signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0099645Biological processneurotransmitter receptor localization to postsynaptic specialization membrane
GO_0033080Biological processimmature T cell proliferation in thymus
GO_0007166Biological processcell surface receptor signaling pathway
GO_0032587Cellular componentruffle membrane
GO_0016324Cellular componentapical plasma membrane
GO_0002116Cellular componentsemaphorin receptor complex
GO_0043235Cellular componentreceptor complex
GO_0043209Cellular componentmyelin sheath
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0005654Cellular componentnucleoplasm
GO_0009925Cellular componentbasal plasma membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0038143Cellular componentERBB3:ERBB2 complex
GO_0005829Cellular componentcytosol
GO_0010008Cellular componentendosome membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005634Cellular componentnucleus
GO_0015026Molecular functioncoreceptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005102Molecular functionsignaling receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0001042Molecular functionRNA polymerase I core binding
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0019838Molecular functiongrowth factor binding
GO_0043125Molecular functionErbB-3 class receptor binding
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameERBB2
Protein nameErb-b2 receptor tyrosine kinase 2
Receptor protein-tyrosine kinase (EC 2.7.10.1)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
receptor protein-tyrosine kinase (EC 2.7.10.1)
Receptor tyrosine-protein kinase erbB-2 (Proto-oncogene c-ErbB-2) (p185erbB2)
Alternative protein ERBB2
V-erb-b2 avian erythroblastic leukemia viral oncoprotein 2 isoform C
Receptor tyrosine-protein kinase erbB-2 variant (EC 2.7.10.1)
ERBB2
Truncated HER2 splice variant p100
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Proto-oncogene c-ErbB-2) (p185erbB2)
SynonymsNGL
NEU
hCG_28177
HER-2
HER2
MLN19
DescriptionFUNCTION: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. .; FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. .

FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. .

FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. .

FUNCTION: In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. .

AccessionsENST00000584450.5
Q9NP09
Q4H1F2
J3QRJ7
Q4H1F1
ENST00000580074.1
ENST00000582648.5
ENST00000584601.5 [P04626-5]
X5DNK3
ENST00000541774.5 [P04626-4]
J3QLV2
J3QL83
ENST00000269571.10 [P04626-1]
J3QRX1
L8E8G2
ENST00000406381.6 [P04626-5]
ENST00000582818.5
J3KTI5
Q9UK79
P04626
ENST00000578709.5
ENST00000578199.5
J3QLU9
E2I6F8
F5H1T4
ENST00000445658.6
X5DQX2
A0A7T8JKQ4
B4DTR1
ENST00000578502.1
J3KRI9
ENST00000578373.5
A0A0R9RWK2