Interactors | Protein name | Directionality | Classification | |
|---|---|---|---|---|
| 1 | AREG-EGFR | AREG_HUMAN - EGFR_HUMAN | Ligand-Receptor | Signaling by Epidermal growth factor |
| 2 | BTC-EGFR | BTC_HUMAN - EGFR_HUMAN | Ligand-Receptor | Signaling by Epidermal growth factor |
| 3 | EGF-EGFR | EGF_HUMAN - EGFR_HUMAN | Ligand-Receptor | Signaling by Epidermal growth factor |
| 4 | EREG-EGFR | EREG_HUMAN - EGFR_HUMAN | Ligand-Receptor | Signaling by Epidermal growth factor |
| 5 | HBEGF-EGFR | HBEGF_HUMAN - EGFR_HUMAN | Ligand-Receptor | Signaling by Epidermal growth factor |
| 6 | HBEGF-ERBB2 | HBEGF_HUMAN - ERBB2_HUMAN | Ligand-Receptor | Signaling by Epidermal growth factor |
| 7 | TGFA-EGFR | TGFA_HUMAN - EGFR_HUMAN | Ligand-Receptor | Signaling by Transforming growth factor |
| Name | ERBB2-EGFR signaling pathway |
| ID | GO_0038134 |
| collection_id | Biological process |
| Exact synonym | EGFR-HER2 signaling pathway, ERBB2-EGFR signalling pathway |
| Description | The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. |
| External URL | |
| Genes |