Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| Mueller cell | 6 studies | 39% ± 22% | |
| kidney distal convoluted tubule epithelial cell | 4 studies | 74% ± 10% | |
| kidney loop of Henle epithelial cell | 4 studies | 59% ± 14% | |
| cardiac muscle cell | 3 studies | 19% ± 4% | |
| glutamatergic neuron | 3 studies | 22% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| kidney | 4 studies | 27% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 78% | 226.68 | 191 / 245 | 86% | 5.76 | 430 / 502 |
| kidney | 100% | 3779.08 | 89 / 89 | 58% | 5.97 | 523 / 901 |
| pancreas | 100% | 4394.51 | 328 / 328 | 35% | 1.18 | 63 / 178 |
| breast | 61% | 644.54 | 279 / 459 | 71% | 5.01 | 795 / 1118 |
| lung | 66% | 161.46 | 384 / 578 | 62% | 3.32 | 714 / 1155 |
| thymus | 93% | 246.61 | 610 / 653 | 22% | 0.65 | 135 / 605 |
| muscle | 100% | 4465.00 | 803 / 803 | 0% | 0 | 0 / 0 |
| skin | 63% | 133.06 | 1142 / 1809 | 36% | 1.16 | 169 / 472 |
| heart | 92% | 492.93 | 793 / 861 | 0% | 0 | 0 / 0 |
| brain | 35% | 47.40 | 914 / 2642 | 56% | 1.41 | 394 / 705 |
| bladder | 52% | 104.48 | 11 / 21 | 20% | 0.95 | 103 / 504 |
| uterus | 55% | 83.94 | 94 / 170 | 17% | 0.63 | 76 / 459 |
| intestine | 31% | 49.54 | 298 / 966 | 23% | 0.98 | 119 / 527 |
| esophagus | 20% | 24.65 | 294 / 1445 | 31% | 1.01 | 56 / 183 |
| peripheral blood | 30% | 50.14 | 278 / 929 | 0% | 0 | 0 / 0 |
| spleen | 22% | 23.06 | 52 / 241 | 0% | 0 | 0 / 0 |
| stomach | 1% | 1.32 | 2 / 359 | 19% | 0.96 | 55 / 286 |
| eye | 0% | 0 | 0 / 0 | 18% | 0.40 | 14 / 80 |
| liver | 0% | 0 | 0 / 226 | 16% | 0.52 | 64 / 406 |
| adrenal gland | 2% | 3.20 | 6 / 258 | 7% | 0.24 | 16 / 230 |
| ovary | 1% | 0.92 | 2 / 180 | 6% | 0.16 | 25 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.34 | 2 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.25 | 3 / 45 |
| adipose | 2% | 3.89 | 23 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 1% | 3.51 | 15 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042327 | Biological process | positive regulation of phosphorylation |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0001525 | Biological process | angiogenesis |
| GO_0090279 | Biological process | regulation of calcium ion import |
| GO_0090370 | Biological process | negative regulation of cholesterol efflux |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0048754 | Biological process | branching morphogenesis of an epithelial tube |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_2000008 | Biological process | regulation of protein localization to cell surface |
| GO_0060749 | Biological process | mammary gland alveolus development |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_1902966 | Biological process | positive regulation of protein localization to early endosome |
| GO_0002092 | Biological process | positive regulation of receptor internalization |
| GO_1905278 | Biological process | positive regulation of epithelial tube formation |
| GO_0070371 | Biological process | ERK1 and ERK2 cascade |
| GO_0038134 | Biological process | ERBB2-EGFR signaling pathway |
| GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0021930 | Biological process | cerebellar granule cell precursor proliferation |
| GO_0021940 | Biological process | positive regulation of cerebellar granule cell precursor proliferation |
| GO_0043388 | Biological process | positive regulation of DNA binding |
| GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0051048 | Biological process | negative regulation of secretion |
| GO_0010800 | Biological process | positive regulation of peptidyl-threonine phosphorylation |
| GO_1900127 | Biological process | positive regulation of hyaluronan biosynthetic process |
| GO_0046425 | Biological process | regulation of receptor signaling pathway via JAK-STAT |
| GO_0045840 | Biological process | positive regulation of mitotic nuclear division |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0005154 | Molecular function | epidermal growth factor receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0030297 | Molecular function | transmembrane receptor protein tyrosine kinase activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | EGF |
| Protein name | Epidermal growth factor Alternative protein EGF Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)] |
| Synonyms | |
| Description | FUNCTION: EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro . . |
| Accessions | ENST00000652245.1 Q6QBS2 ENST00000265171.10 [P01133-1] ENST00000509793.5 [P01133-2] L8EC91 P01133 ENST00000503392.1 [P01133-3] A0A494C018 |
