AREG | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	31 studies	40% ± 17%	Explore
conventional dendritic cell	25 studies	38% ± 12%	Explore
mast cell	23 studies	52% ± 23%	Explore
dendritic cell	16 studies	40% ± 14%	Explore
plasmacytoid dendritic cell	16 studies	44% ± 17%	Explore
classical monocyte	15 studies	43% ± 13%	Explore
B cell	14 studies	27% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	54% ± 17%	Explore
monocyte	13 studies	31% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	42% ± 15%	Explore
CD4-positive, alpha-beta T cell	13 studies	23% ± 7%	Explore
basal cell	13 studies	31% ± 8%	Explore
macrophage	12 studies	30% ± 10%	Explore
naive B cell	10 studies	24% ± 5%	Explore
epithelial cell	10 studies	36% ± 12%	Explore
innate lymphoid cell	9 studies	55% ± 26%	Explore
mature NK T cell	9 studies	33% ± 17%	Explore
gamma-delta T cell	9 studies	36% ± 16%	Explore
memory B cell	9 studies	28% ± 9%	Explore
T cell	8 studies	29% ± 10%	Explore
type II pneumocyte	8 studies	35% ± 17%	Explore
CD8-positive, alpha-beta T cell	8 studies	24% ± 6%	Explore
ciliated cell	7 studies	28% ± 12%	Explore
non-classical monocyte	7 studies	34% ± 11%	Explore
hematopoietic stem cell	6 studies	41% ± 21%	Explore
intermediate monocyte	5 studies	37% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	28% ± 9%	Explore
plasma cell	4 studies	33% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
mucosal invariant T cell	4 studies	21% ± 1%	Explore
myeloid cell	4 studies	32% ± 6%	Explore
alveolar macrophage	4 studies	29% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	69% ± 8%	Explore
regulatory T cell	4 studies	19% ± 2%	Explore
granulocyte	4 studies	40% ± 18%	Explore
monocyte-derived dendritic cell	4 studies	37% ± 15%	Explore
T follicular helper cell	4 studies	39% ± 17%	Explore
group 3 innate lymphoid cell	4 studies	59% ± 15%	Explore
smooth muscle cell	3 studies	20% ± 3%	Explore
mononuclear phagocyte	3 studies	37% ± 26%	Explore
goblet cell	3 studies	34% ± 20%	Explore
CD4-positive helper T cell	3 studies	26% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	28% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	26% ± 7%	Explore
neutrophil	3 studies	34% ± 6%	Explore
inflammatory macrophage	3 studies	26% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	40% ± 9%	Explore
secretory cell	3 studies	37% ± 16%	Explore
leukocyte	3 studies	47% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	11 studies	26% ± 6%	Explore
peripheral blood	6 studies	21% ± 5%	Explore
intestine	5 studies	20% ± 4%	Explore
breast	4 studies	28% ± 8%	Explore
prostate	3 studies	32% ± 5%	Explore
lymph node	3 studies	30% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	97%	2080.12	562 / 578	70%	86.56	809 / 1155
intestine	64%	484.97	623 / 966	93%	169.37	488 / 527
breast	97%	1959.89	443 / 459	60%	115.53	670 / 1118
esophagus	75%	897.05	1080 / 1445	80%	82.08	147 / 183
stomach	69%	672.38	249 / 359	80%	149.12	229 / 286
bladder	52%	249.24	11 / 21	60%	111.63	300 / 504
ureter	0%	0	0 / 0	100%	37.48	1 / 1
adipose	90%	1837.28	1089 / 1204	0%	0	0 / 0
pancreas	11%	43.35	36 / 328	79%	69.93	141 / 178
skin	80%	623.72	1441 / 1809	7%	10.44	34 / 472
spleen	68%	533.73	164 / 241	0%	0	0 / 0
uterus	19%	121.22	32 / 170	47%	40.39	215 / 459
heart	65%	613.21	560 / 861	0%	0	0 / 0
prostate	50%	348.01	123 / 245	9%	2.98	46 / 502
ovary	45%	608.36	81 / 180	12%	4.81	50 / 430
peripheral blood	53%	924.39	495 / 929	0%	0	0 / 0
blood vessel	52%	348.74	700 / 1335	0%	0	0 / 0
muscle	48%	579.46	387 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	42%	47.94	19 / 45
kidney	20%	90.48	18 / 89	16%	6.09	148 / 901
thymus	19%	70.95	125 / 653	16%	6.60	98 / 605
adrenal gland	24%	97.36	63 / 258	10%	7.28	22 / 230
liver	11%	39.98	25 / 226	7%	3.18	27 / 406
brain	1%	2.59	24 / 2642	2%	0.97	14 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042542	Biological process	response to hydrogen peroxide
GO_0032355	Biological process	response to estradiol
GO_0043434	Biological process	response to peptide hormone
GO_0060744	Biological process	mammary gland branching involved in thelarche
GO_0060750	Biological process	epithelial cell proliferation involved in mammary gland duct elongation
GO_0031175	Biological process	neuron projection development
GO_0060749	Biological process	mammary gland alveolus development
GO_0010838	Biological process	positive regulation of keratinocyte proliferation
GO_0007267	Biological process	cell-cell signaling
GO_0060598	Biological process	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
GO_0051591	Biological process	response to cAMP
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0038134	Biological process	ERBB2-EGFR signaling pathway
GO_0051384	Biological process	response to glucocorticoid
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0014009	Biological process	glial cell proliferation
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0009986	Cellular component	cell surface
GO_0012507	Cellular component	ER to Golgi transport vesicle membrane
GO_0005634	Cellular component	nucleus
GO_0048018	Molecular function	receptor ligand activity
GO_0005154	Molecular function	epidermal growth factor receptor binding
GO_0008083	Molecular function	growth factor activity
GO_0030297	Molecular function	transmembrane receptor protein tyrosine kinase activator activity
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	AREG
Protein name	Amphiregulin Amphiregulin (AR) (Colorectum cell-derived growth factor) (CRDGF)
Synonyms	AREGB SDGF
Description	FUNCTION: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Accessions	ENST00000502307.1 P15514 D6RFX5 ENST00000395748.8

AREG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review