EREG | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	19 studies	40% ± 21%	Explore
monocyte	11 studies	34% ± 20%	Explore
conventional dendritic cell	10 studies	23% ± 7%	Explore
non-classical monocyte	9 studies	32% ± 17%	Explore
macrophage	8 studies	34% ± 14%	Explore
dendritic cell	6 studies	26% ± 7%	Explore
hematopoietic stem cell	6 studies	32% ± 11%	Explore
myeloid cell	4 studies	28% ± 13%	Explore
hematopoietic precursor cell	3 studies	26% ± 11%	Explore
squamous epithelial cell	3 studies	26% ± 10%	Explore
mononuclear phagocyte	3 studies	28% ± 12%	Explore
basal cell	3 studies	25% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	24% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	90%	967.64	1304 / 1445	63%	21.40	115 / 183
intestine	63%	186.51	606 / 966	71%	27.27	374 / 527
lung	88%	586.08	509 / 578	32%	12.41	375 / 1155
ureter	0%	0	0 / 0	100%	4.43	1 / 1
skin	83%	1359.32	1504 / 1809	8%	1.87	38 / 472
stomach	13%	35.99	48 / 359	53%	24.82	151 / 286
bladder	10%	32.00	2 / 21	48%	20.31	244 / 504
pancreas	4%	8.57	12 / 328	51%	8.72	90 / 178
peripheral blood	47%	308.26	436 / 929	0%	0	0 / 0
spleen	36%	109.98	87 / 241	0%	0	0 / 0
adipose	36%	202.38	429 / 1204	0%	0	0 / 0
breast	19%	49.98	85 / 459	11%	1.52	122 / 1118
uterus	5%	28.15	9 / 170	23%	4.67	105 / 459
blood vessel	23%	73.40	313 / 1335	0%	0	0 / 0
heart	22%	73.55	187 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	20%	3.47	9 / 45
kidney	6%	20.28	5 / 89	11%	1.18	95 / 901
thymus	1%	2.30	9 / 653	13%	1.03	76 / 605
liver	5%	13.60	12 / 226	7%	1.41	30 / 406
ovary	7%	10.74	12 / 180	3%	0.18	13 / 430
prostate	7%	15.78	17 / 245	0%	0.02	2 / 502
adrenal gland	2%	2.50	4 / 258	2%	1.03	5 / 230
brain	0%	1.20	10 / 2642	2%	0.24	17 / 705
muscle	1%	1.07	6 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042327	Biological process	positive regulation of phosphorylation
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0030216	Biological process	keratinocyte differentiation
GO_0001525	Biological process	angiogenesis
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0051781	Biological process	positive regulation of cell division
GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0043434	Biological process	response to peptide hormone
GO_0009887	Biological process	animal organ morphogenesis
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0007143	Biological process	female meiotic nuclear division
GO_0051151	Biological process	negative regulation of smooth muscle cell differentiation
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0007267	Biological process	cell-cell signaling
GO_0045089	Biological process	positive regulation of innate immune response
GO_0042700	Biological process	luteinizing hormone signaling pathway
GO_0042060	Biological process	wound healing
GO_0001556	Biological process	oocyte maturation
GO_0045860	Biological process	positive regulation of protein kinase activity
GO_0048160	Biological process	primary follicle stage
GO_0038138	Biological process	ERBB4-ERBB4 signaling pathway
GO_0030728	Biological process	ovulation
GO_0038134	Biological process	ERBB2-EGFR signaling pathway
GO_0045740	Biological process	positive regulation of DNA replication
GO_0001550	Biological process	ovarian cumulus expansion
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0038135	Biological process	ERBB2-ERBB4 signaling pathway
GO_0001819	Biological process	positive regulation of cytokine production
GO_0009299	Biological process	mRNA transcription
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0043616	Biological process	keratinocyte proliferation
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0048018	Molecular function	receptor ligand activity
GO_0005154	Molecular function	epidermal growth factor receptor binding
GO_0008083	Molecular function	growth factor activity
GO_0030297	Molecular function	transmembrane receptor protein tyrosine kinase activator activity
GO_0005515	Molecular function	protein binding

Gene name	EREG
Protein name	Proepiregulin [Cleaved into: Epiregulin (EPR)] Alternative protein EREG
Synonyms
Description	FUNCTION: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation . Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation . .
Accessions	ENST00000244869.3 O14944 L8E9W3

EREG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review