EGFR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	23 studies	32% ± 14%	Explore
basal cell	17 studies	44% ± 25%	Explore
astrocyte	17 studies	43% ± 20%	Explore
endothelial cell	17 studies	32% ± 14%	Explore
type I pneumocyte	11 studies	40% ± 18%	Explore
oligodendrocyte precursor cell	11 studies	39% ± 18%	Explore
epithelial cell	10 studies	33% ± 18%	Explore
pericyte	10 studies	25% ± 6%	Explore
adipocyte	10 studies	49% ± 14%	Explore
ciliated cell	8 studies	23% ± 8%	Explore
type II pneumocyte	7 studies	37% ± 15%	Explore
club cell	7 studies	32% ± 12%	Explore
smooth muscle cell	7 studies	27% ± 7%	Explore
ionocyte	5 studies	46% ± 9%	Explore
hepatocyte	5 studies	62% ± 26%	Explore
abnormal cell	5 studies	38% ± 13%	Explore
Mueller cell	5 studies	38% ± 10%	Explore
respiratory goblet cell	5 studies	36% ± 16%	Explore
GABAergic neuron	5 studies	42% ± 9%	Explore
cholangiocyte	4 studies	55% ± 19%	Explore
interneuron	4 studies	55% ± 28%	Explore
mesothelial cell	4 studies	35% ± 8%	Explore
myofibroblast cell	4 studies	32% ± 11%	Explore
secretory cell	3 studies	25% ± 7%	Explore
hepatic stellate cell	3 studies	39% ± 17%	Explore
GABAergic interneuron	3 studies	31% ± 7%	Explore
placental villous trophoblast	3 studies	81% ± 15%	Explore
squamous epithelial cell	3 studies	29% ± 18%	Explore
neural progenitor cell	3 studies	24% ± 4%	Explore
connective tissue cell	3 studies	28% ± 11%	Explore
adventitial cell	3 studies	29% ± 8%	Explore
capillary endothelial cell	3 studies	26% ± 3%	Explore
goblet cell	3 studies	33% ± 23%	Explore
transit amplifying cell	3 studies	47% ± 37%	Explore
renal principal cell	3 studies	20% ± 3%	Explore
mucus secreting cell	3 studies	37% ± 3%	Explore
myoepithelial cell	3 studies	40% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	21% ± 6%	Explore
lung	7 studies	24% ± 7%	Explore
heart	4 studies	19% ± 2%	Explore
liver	3 studies	36% ± 12%	Explore
placenta	3 studies	40% ± 8%	Explore
adipose	3 studies	44% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9734.15	1445 / 1445	97%	188.44	177 / 183
prostate	100%	8101.59	245 / 245	92%	31.45	462 / 502
thymus	99%	6565.00	649 / 653	90%	40.43	547 / 605
lung	98%	6352.30	567 / 578	90%	76.68	1037 / 1155
uterus	100%	5801.86	170 / 170	81%	56.36	370 / 459
liver	100%	7424.42	226 / 226	76%	23.46	309 / 406
bladder	100%	6194.24	21 / 21	76%	43.35	382 / 504
intestine	99%	5608.16	958 / 966	76%	24.32	401 / 527
kidney	84%	2927.72	75 / 89	90%	69.06	810 / 901
stomach	94%	4355.54	336 / 359	77%	30.87	221 / 286
pancreas	87%	3163.86	284 / 328	82%	25.52	146 / 178
brain	54%	1695.71	1430 / 2642	97%	279.74	682 / 705
breast	100%	10410.21	458 / 459	35%	19.63	394 / 1118
ovary	100%	5058.16	180 / 180	30%	6.20	131 / 430
adrenal gland	97%	5345.69	251 / 258	18%	4.27	41 / 230
skin	100%	21813.63	1809 / 1809	7%	2.92	35 / 472
adipose	100%	10666.18	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7137.93	1333 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	76.01	42 / 45
muscle	77%	2756.27	616 / 803	0%	0	0 / 0
spleen	57%	1634.29	137 / 241	0%	0	0 / 0
heart	56%	1498.10	480 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_0030324	Biological process	lung development
GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0070141	Biological process	response to UV-A
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_0060571	Biological process	morphogenesis of an epithelial fold
GO_0007275	Biological process	multicellular organism development
GO_0071392	Biological process	cellular response to estradiol stimulus
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_0050730	Biological process	regulation of peptidyl-tyrosine phosphorylation
GO_0033590	Biological process	response to cobalamin
GO_0038134	Biological process	ERBB2-EGFR signaling pathway
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045740	Biological process	positive regulation of DNA replication
GO_1902895	Biological process	positive regulation of miRNA transcription
GO_1900020	Biological process	positive regulation of protein kinase C activity
GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0016101	Biological process	diterpenoid metabolic process
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0051592	Biological process	response to calcium ion
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0050673	Biological process	epithelial cell proliferation
GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0046328	Biological process	regulation of JNK cascade
GO_0042743	Biological process	hydrogen peroxide metabolic process
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0071549	Biological process	cellular response to dexamethasone stimulus
GO_0000165	Biological process	MAPK cascade
GO_0060252	Biological process	positive regulation of glial cell proliferation
GO_0001892	Biological process	embryonic placenta development
GO_0048143	Biological process	astrocyte activation
GO_0007165	Biological process	signal transduction
GO_0006412	Biological process	translation
GO_0007494	Biological process	midgut development
GO_0071276	Biological process	cellular response to cadmium ion
GO_0021795	Biological process	cerebral cortex cell migration
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0097421	Biological process	liver regeneration
GO_0051205	Biological process	protein insertion into membrane
GO_0032930	Biological process	positive regulation of superoxide anion generation
GO_0045930	Biological process	negative regulation of mitotic cell cycle
GO_0046777	Biological process	protein autophosphorylation
GO_0048546	Biological process	digestive tract morphogenesis
GO_0061029	Biological process	eyelid development in camera-type eye
GO_0042327	Biological process	positive regulation of phosphorylation
GO_0051896	Biological process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0045739	Biological process	positive regulation of DNA repair
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0045907	Biological process	positive regulation of vasoconstriction
GO_0043586	Biological process	tongue development
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0048812	Biological process	neuron projection morphogenesis
GO_0038083	Biological process	peptidyl-tyrosine autophosphorylation
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0033674	Biological process	positive regulation of kinase activity
GO_0046718	Biological process	symbiont entry into host cell
GO_0022008	Biological process	neurogenesis
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0042311	Biological process	vasodilation
GO_0007435	Biological process	salivary gland morphogenesis
GO_0070257	Biological process	positive regulation of mucus secretion
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0034614	Biological process	cellular response to reactive oxygen species
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0030307	Biological process	positive regulation of cell growth
GO_0042059	Biological process	negative regulation of epidermal growth factor receptor signaling pathway
GO_0007611	Biological process	learning or memory
GO_0045737	Biological process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0042698	Biological process	ovulation cycle
GO_0007623	Biological process	circadian rhythm
GO_1905208	Biological process	negative regulation of cardiocyte differentiation
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0030335	Biological process	positive regulation of cell migration
GO_0033594	Biological process	response to hydroxyisoflavone
GO_0001942	Biological process	hair follicle development
GO_0051968	Biological process	positive regulation of synaptic transmission, glutamatergic
GO_0001503	Biological process	ossification
GO_0098609	Biological process	cell-cell adhesion
GO_0045780	Biological process	positive regulation of bone resorption
GO_1902722	Biological process	positive regulation of prolactin secretion
GO_0045121	Cellular component	membrane raft
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0009925	Cellular component	basal plasma membrane
GO_0009986	Cellular component	cell surface
GO_0010008	Cellular component	endosome membrane
GO_0005768	Cellular component	endosome
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005634	Cellular component	nucleus
GO_0031901	Cellular component	early endosome membrane
GO_0097489	Cellular component	multivesicular body, internal vesicle lumen
GO_0005615	Cellular component	extracellular space
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0032991	Cellular component	protein-containing complex
GO_0097708	Cellular component	intracellular vesicle
GO_0000139	Cellular component	Golgi membrane
GO_0070435	Cellular component	Shc-EGFR complex
GO_0005737	Cellular component	cytoplasm
GO_0032587	Cellular component	ruffle membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005925	Cellular component	focal adhesion
GO_0030054	Cellular component	cell junction
GO_0031965	Cellular component	nuclear membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0042802	Molecular function	identical protein binding
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0001618	Molecular function	virus receptor activity
GO_0004709	Molecular function	MAP kinase kinase kinase activity
GO_0005524	Molecular function	ATP binding
GO_0051117	Molecular function	ATPase binding
GO_0003682	Molecular function	chromatin binding
GO_0003690	Molecular function	double-stranded DNA binding
GO_0019900	Molecular function	kinase binding
GO_0048408	Molecular function	epidermal growth factor binding
GO_0005516	Molecular function	calmodulin binding
GO_0019899	Molecular function	enzyme binding
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0051015	Molecular function	actin filament binding
GO_0030296	Molecular function	protein tyrosine kinase activator activity
GO_0030297	Molecular function	transmembrane receptor protein tyrosine kinase activator activity
GO_0005515	Molecular function	protein binding
GO_0005006	Molecular function	epidermal growth factor receptor activity
GO_0019903	Molecular function	protein phosphatase binding
GO_0045296	Molecular function	cadherin binding
GO_0019901	Molecular function	protein kinase binding
GO_0004714	Molecular function	transmembrane receptor protein tyrosine kinase activity
GO_0005178	Molecular function	integrin binding

IV. Literature review

[source]

Gene name	EGFR
Protein name	Receptor protein-tyrosine kinase (EC 2.7.10.1) Alternative protein EGFR Epidermal growth factor receptor protein-tyrosine kinase (EC 2.7.10.1) Epidermal growth factor receptor variant EX12_14del Epidermal growth factor receptor variant EX12_15del Truncated epidermal growth factor receptor Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1) Epidermal growth factor receptor A431-specific truncated epidermal growth factor receptor
Synonyms	ERBB1 ERBB HER1
Description	FUNCTION: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses . Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF . Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules . May also activate the NF-kappa-B signaling cascade . Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling . Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin . Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration . Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity). .; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. .
Accessions	ENST00000275493.7 [P00533-1] A0A068JCC9 ENST00000455089.5 A7VN06 C9JYS6 G9MC26 I3WA72 Q9H3D0 A7VMV4 I3WA73 Q68GS6 E7BSV0 A0A1Y0DMK7 A0A068JD88 A7VN05 G9MC81 ENST00000700145.1 E2I6F5 Q8WZA5 A0A7S9GFS3 P00533 I3WA68 A7VN07 A2VCQ7 ENST00000420316.6 [P00533-2] Q30BI0 B6RC66 A0A8V8TPW8 F1JTL6 B6RC65 Q8NDU8 ENST00000450046.2 ENST00000344576.7 [P00533-3] ENST00000342916.7 [P00533-4] Q9H3C8 Q75MF2 Q504U8 Q4H1F3 L0R6G1 Q147T7

EGFR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review