HBEGF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030307Biological processpositive regulation of cell growth
GO_0051545Biological processnegative regulation of elastin biosynthetic process
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0007165Biological processsignal transduction
GO_0038134Biological processERBB2-EGFR signaling pathway
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0030335Biological processpositive regulation of cell migration
GO_0051549Biological processpositive regulation of keratinocyte migration
GO_0007517Biological processmuscle organ development
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0038135Biological processERBB2-ERBB4 signaling pathway
GO_0035313Biological processwound healing, spreading of epidermal cells
GO_0008016Biological processregulation of heart contraction
GO_0060326Biological processcell chemotaxis
GO_0090303Biological processpositive regulation of wound healing
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0009986Cellular componentcell surface
GO_0008201Molecular functionheparin binding
GO_0048018Molecular functionreceptor ligand activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0008083Molecular functiongrowth factor activity
GO_0005515Molecular functionprotein binding
GO_0030297Molecular functiontransmembrane receptor protein tyrosine kinase activator activity

IV. Literature review

[source]
Gene nameHBEGF
Protein nameProheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)]
Short form heparin-binding EGF-like growth factor
SynonymsDTS
HEGFL
DTR
DescriptionFUNCTION: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

AccessionsQ99075
ENST00000230990.7
Q1HK36