I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 4 studies | 28% ± 9% | |
| squamous epithelial cell | 3 studies | 35% ± 17% | |
| oligodendrocyte | 3 studies | 20% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 4 studies | 28% ± 9% | |
| squamous epithelial cell | 3 studies | 35% ± 17% | |
| oligodendrocyte | 3 studies | 20% ± 2% |
Insufficient scRNA-seq data for expression of TGFA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 98% | 621.45 | 322 / 328 | 90% | 31.22 | 161 / 178 |
| kidney | 100% | 1094.18 | 89 / 89 | 88% | 81.02 | 795 / 901 |
| thymus | 99% | 652.03 | 648 / 653 | 86% | 60.84 | 522 / 605 |
| lung | 89% | 480.59 | 515 / 578 | 87% | 31.37 | 1002 / 1155 |
| brain | 99% | 1060.10 | 2604 / 2642 | 59% | 10.18 | 415 / 705 |
| bladder | 52% | 384.48 | 11 / 21 | 85% | 25.83 | 429 / 504 |
| stomach | 60% | 303.57 | 216 / 359 | 77% | 14.20 | 220 / 286 |
| esophagus | 40% | 1196.56 | 582 / 1445 | 95% | 39.78 | 173 / 183 |
| intestine | 43% | 576.30 | 416 / 966 | 84% | 17.08 | 443 / 527 |
| spleen | 95% | 677.94 | 228 / 241 | 0% | 0 | 0 / 0 |
| skin | 72% | 1596.16 | 1306 / 1809 | 15% | 9.48 | 69 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 34.02 | 38 / 45 |
| uterus | 5% | 54.44 | 8 / 170 | 79% | 30.10 | 363 / 459 |
| prostate | 56% | 244.95 | 138 / 245 | 24% | 2.86 | 122 / 502 |
| breast | 43% | 256.36 | 197 / 459 | 35% | 6.26 | 392 / 1118 |
| liver | 55% | 168.11 | 124 / 226 | 21% | 6.07 | 84 / 406 |
| peripheral blood | 71% | 1167.68 | 657 / 929 | 0% | 0 | 0 / 0 |
| ovary | 2% | 4.62 | 3 / 180 | 40% | 6.12 | 170 / 430 |
| adipose | 11% | 39.22 | 136 / 1204 | 0% | 0 | 0 / 0 |
| heart | 5% | 14.84 | 39 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.26 | 1 / 29 |
| adrenal gland | 0% | 0 | 0 / 258 | 3% | 0.66 | 7 / 230 |
| blood vessel | 2% | 7.52 | 32 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.54 | 2 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0051781 | Biological process | positive regulation of cell division |
| GO_0060749 | Biological process | mammary gland alveolus development |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0038134 | Biological process | ERBB2-EGFR signaling pathway |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0072574 | Biological process | hepatocyte proliferation |
| GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0045840 | Biological process | positive regulation of mitotic nuclear division |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
| GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0012507 | Cellular component | ER to Golgi transport vesicle membrane |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0005154 | Molecular function | epidermal growth factor receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0030297 | Molecular function | transmembrane receptor protein tyrosine kinase activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TGFA |
| Protein name | Transforming growth factor alpha (Transforming growth factor, alpha, isoform CRA_d) Transforming growth factor alpha Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)] |
| Synonyms | hCG_40573 |
| Description | FUNCTION: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
| Accessions | F8VNR3 Q15578 ENST00000450929.5 F8WA74 H0Y6S5 ENST00000445399.5 [P01135-3] ENST00000419940.5 E7EPT6 ENST00000444975.5 ENST00000418333.6 [P01135-2] Q9UE87 P01135 ENST00000394241.3 ENST00000295400.11 [P01135-1] Q9UQ91 |
