MYOC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MYOC at tissue level.

III. Associated gene sets

GO_0035024Biological processnegative regulation of Rho protein signal transduction
GO_0038133Biological processERBB2-ERBB3 signaling pathway
GO_0051901Biological processpositive regulation of mitochondrial depolarization
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0001649Biological processosteoblast differentiation
GO_0031175Biological processneuron projection development
GO_0046330Biological processpositive regulation of JNK cascade
GO_0007165Biological processsignal transduction
GO_0045162Biological processclustering of voltage-gated sodium channels
GO_0001953Biological processnegative regulation of cell-matrix adhesion
GO_0022011Biological processmyelination in peripheral nervous system
GO_0014734Biological processskeletal muscle hypertrophy
GO_0030335Biological processpositive regulation of cell migration
GO_0051894Biological processpositive regulation of focal adhesion assembly
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0035567Biological processnon-canonical Wnt signaling pathway
GO_0043408Biological processregulation of MAPK cascade
GO_0060348Biological processbone development
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0005615Cellular componentextracellular space
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005929Cellular componentcilium
GO_0005783Cellular componentendoplasmic reticulum
GO_0033268Cellular componentnode of Ranvier
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0005109Molecular functionfrizzled binding
GO_0001968Molecular functionfibronectin binding
GO_0046872Molecular functionmetal ion binding
GO_0032027Molecular functionmyosin light chain binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameMYOC
Protein nameMyocilin trabecular meshwork inducible glucocorticoid response isoform 5
Myocilin trabecular meshwork inducible glucocorticoid response isoform 4
Myocilin (Trabecular meshwork-induced glucocorticoid response protein)
Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]
Myocilin trabecular meshwork inducible glucocorticoid response isoform 3
Myocilin
SynonymsTIGR
GLC1A
DescriptionFUNCTION: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork. .

AccessionsENST00000037502.11
A0A1W2PP09
A0A140CTX2
Q99972
B6V6K6
A0A7T6ZKF8
A0A0S2Z481
ENST00000638471.1
A0A0H3W5P3
B6ECI7
A0A7T6ZK44
A0A7G3V676
A0A140CTX3
B6V6K7
A0A7T6ZL00
A0A7T6ZK79
A0A0S2Z421
A0A140CTX4
A0A140CTW9
A0A7T6ZK47
A0A140CTX1
A0A0S2Z412
Q6PKX1
A0A140CTX0
A0A0S2Z416