HMGB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0006303Biological processdouble-strand break repair via nonhomologous end joining
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0045654Biological processpositive regulation of megakaryocyte differentiation
GO_0010629Biological processnegative regulation of gene expression
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0050918Biological processpositive chemotaxis
GO_0033151Biological processV(D)J recombination
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007289Biological processspermatid nucleus differentiation
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0045089Biological processpositive regulation of innate immune response
GO_0006334Biological processnucleosome assembly
GO_0072091Biological processregulation of stem cell proliferation
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0006265Biological processDNA topological change
GO_0045648Biological processpositive regulation of erythrocyte differentiation
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0008584Biological processmale gonad development
GO_0048545Biological processresponse to steroid hormone
GO_0032392Biological processDNA geometric change
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0050767Biological processregulation of neurogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0060326Biological processcell chemotaxis
GO_0032496Biological processresponse to lipopolysaccharide
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005615Cellular componentextracellular space
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000793Cellular componentcondensed chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003677Molecular functionDNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0008301Molecular functionDNA binding, bending
GO_0019904Molecular functionprotein domain specific binding
GO_0000987Molecular functioncis-regulatory region sequence-specific DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0042056Molecular functionchemoattractant activity
GO_0097100Molecular functionsupercoiled DNA binding
GO_0003723Molecular functionRNA binding
GO_0044378Molecular functionnon-sequence-specific DNA binding, bending
GO_0003713Molecular functiontranscription coactivator activity
GO_0050786Molecular functionRAGE receptor binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameHMGB2
Protein nameHigh mobility group protein B2 (High mobility group protein 2)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
SynonymsHMG2
DescriptionFUNCTION: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity . Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE . Has antimicrobial activity in gastrointestinal epithelial tissues . Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity). .

AccessionsENST00000296503.10
D6R9A6
ENST00000506267.1
P26583
ENST00000438704.6
ENST00000446922.6