TNFRSF10B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFRSF10B at tissue level.

III. Associated gene sets

GO_0002357Biological processdefense response to tumor cell
GO_0006915Biological processapoptotic process
GO_0007250Biological processactivation of NF-kappaB-inducing kinase activity
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0008625Biological processextrinsic apoptotic signaling pathway via death domain receptors
GO_0036462Biological processTRAIL-activated apoptotic signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0071260Biological processcellular response to mechanical stimulus
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0043065Biological processpositive regulation of apoptotic process
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0036463Molecular functionTRAIL receptor activity
GO_0038023Molecular functionsignaling receptor activity
GO_0045569Molecular functionTRAIL binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNFRSF10B
Protein nameTumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)
TNFRSF10B protein (Tumor necrosis factor receptor superfamily, member 10b) (cDNA FLJ76289, highly similar to Homo sapiens tumor necrosis factor receptor superfamily, member 10b (TNFRSF10B), transcript variant 1, mRNA)
TNF receptor superfamily member 10b
Tumor necrosis factor receptor superfamily, member 10b
Tumor necrosis factor receptor superfamily member 10B
SynonymsZTNFR9
hCG_1645072
TRICK2
UNQ160/PRO186
KILLER
DR5
TRAILR2
DescriptionFUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL . The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. .

FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. .

FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. .

FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. .

AccessionsE9PBT3
O14763
ENST00000276431.9 [O14763-1]
ENST00000523504.5
Q6FH58
D3DSR9
ENST00000347739.3 [O14763-2]
B5BU36