NOTCH1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	24 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	8 studies	24% ± 8%	Explore
endothelial cell of artery	7 studies	22% ± 4%	Explore
astrocyte	7 studies	27% ± 9%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 7%	Explore
basal cell	5 studies	22% ± 5%	Explore
capillary endothelial cell	5 studies	21% ± 2%	Explore
epithelial cell	4 studies	22% ± 3%	Explore
classical monocyte	3 studies	18% ± 3%	Explore
microglial cell	3 studies	21% ± 2%	Explore
transit amplifying cell	3 studies	30% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7353.27	1445 / 1445	100%	68.97	183 / 183
intestine	100%	8511.86	966 / 966	98%	45.52	519 / 527
uterus	100%	6525.78	170 / 170	96%	38.43	439 / 459
bladder	100%	6692.29	21 / 21	93%	30.56	468 / 504
lung	100%	10898.83	578 / 578	92%	28.73	1068 / 1155
pancreas	99%	3656.97	325 / 328	93%	18.67	166 / 178
breast	100%	7381.41	459 / 459	92%	21.06	1031 / 1118
stomach	93%	4035.55	335 / 359	99%	50.89	282 / 286
skin	96%	8314.56	1744 / 1809	94%	30.86	444 / 472
brain	89%	2755.18	2343 / 2642	100%	82.74	702 / 705
thymus	100%	5798.95	652 / 653	87%	22.03	526 / 605
prostate	100%	7785.83	245 / 245	83%	14.21	415 / 502
kidney	100%	4882.18	89 / 89	82%	20.38	735 / 901
ovary	82%	2173.52	147 / 180	79%	19.89	340 / 430
liver	92%	2221.29	208 / 226	47%	7.25	191 / 406
adrenal gland	89%	1813.88	229 / 258	37%	5.36	86 / 230
adipose	100%	8419.65	1204 / 1204	0%	0	0 / 0
spleen	100%	11721.55	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	12.29	1 / 1
blood vessel	100%	4996.29	1329 / 1335	0%	0	0 / 0
heart	99%	3882.78	854 / 861	0%	0	0 / 0
peripheral blood	98%	7427.64	913 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	69.27	44 / 45
lymph node	0%	0	0 / 0	97%	26.53	28 / 29
eye	0%	0	0 / 0	81%	10.95	65 / 80
muscle	60%	1019.59	484 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002052	Biological process	positive regulation of neuroblast proliferation
GO_0003241	Biological process	growth involved in heart morphogenesis
GO_0006366	Biological process	transcription by RNA polymerase II
GO_2000974	Biological process	negative regulation of pro-B cell differentiation
GO_0061384	Biological process	heart trabecula morphogenesis
GO_2001027	Biological process	negative regulation of endothelial cell chemotaxis
GO_0030324	Biological process	lung development
GO_0048103	Biological process	somatic stem cell division
GO_0021515	Biological process	cell differentiation in spinal cord
GO_0003192	Biological process	mitral valve formation
GO_0001947	Biological process	heart looping
GO_0045662	Biological process	negative regulation of myoblast differentiation
GO_0032495	Biological process	response to muramyl dipeptide
GO_0060843	Biological process	venous endothelial cell differentiation
GO_0032966	Biological process	negative regulation of collagen biosynthetic process
GO_0003157	Biological process	endocardium development
GO_0003203	Biological process	endocardial cushion morphogenesis
GO_0031100	Biological process	animal organ regeneration
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0051152	Biological process	positive regulation of smooth muscle cell differentiation
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0002437	Biological process	inflammatory response to antigenic stimulus
GO_0002085	Biological process	inhibition of neuroepithelial cell differentiation
GO_0006959	Biological process	humoral immune response
GO_0006955	Biological process	immune response
GO_0055008	Biological process	cardiac muscle tissue morphogenesis
GO_0003332	Biological process	negative regulation of extracellular matrix constituent secretion
GO_0070168	Biological process	negative regulation of biomineral tissue development
GO_0061101	Biological process	neuroendocrine cell differentiation
GO_0045955	Biological process	negative regulation of calcium ion-dependent exocytosis
GO_0060528	Biological process	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO_1902339	Biological process	positive regulation of apoptotic process involved in morphogenesis
GO_0030513	Biological process	positive regulation of BMP signaling pathway
GO_0001554	Biological process	luteolysis
GO_0030163	Biological process	protein catabolic process
GO_0060842	Biological process	arterial endothelial cell differentiation
GO_0060982	Biological process	coronary artery morphogenesis
GO_0046579	Biological process	positive regulation of Ras protein signal transduction
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0035924	Biological process	cellular response to vascular endothelial growth factor stimulus
GO_0045618	Biological process	positive regulation of keratinocyte differentiation
GO_0061344	Biological process	regulation of cell adhesion involved in heart morphogenesis
GO_0072538	Biological process	T-helper 17 type immune response
GO_0050673	Biological process	epithelial cell proliferation
GO_0030279	Biological process	negative regulation of ossification
GO_0060271	Biological process	cilium assembly
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0003252	Biological process	negative regulation of cell proliferation involved in heart valve morphogenesis
GO_0003151	Biological process	outflow tract morphogenesis
GO_0070986	Biological process	left/right axis specification
GO_0060979	Biological process	vasculogenesis involved in coronary vascular morphogenesis
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_0007219	Biological process	Notch signaling pathway
GO_0001701	Biological process	in utero embryonic development
GO_0071372	Biological process	cellular response to follicle-stimulating hormone stimulus
GO_0010629	Biological process	negative regulation of gene expression
GO_0003169	Biological process	coronary vein morphogenesis
GO_0007368	Biological process	determination of left/right symmetry
GO_0030900	Biological process	forebrain development
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0010628	Biological process	positive regulation of gene expression
GO_0007386	Biological process	compartment pattern specification
GO_0048711	Biological process	positive regulation of astrocyte differentiation
GO_2000811	Biological process	negative regulation of anoikis
GO_0009957	Biological process	epidermal cell fate specification
GO_0035148	Biological process	tube formation
GO_0003344	Biological process	pericardium morphogenesis
GO_0048708	Biological process	astrocyte differentiation
GO_0003273	Biological process	cell migration involved in endocardial cushion formation
GO_0003208	Biological process	cardiac ventricle morphogenesis
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0062043	Biological process	positive regulation of cardiac epithelial to mesenchymal transition
GO_0060740	Biological process	prostate gland epithelium morphogenesis
GO_0006606	Biological process	protein import into nucleus
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0060412	Biological process	ventricular septum morphogenesis
GO_0003219	Biological process	cardiac right ventricle formation
GO_0009912	Biological process	auditory receptor cell fate commitment
GO_0060354	Biological process	negative regulation of cell adhesion molecule production
GO_0003184	Biological process	pulmonary valve morphogenesis
GO_2000048	Biological process	negative regulation of cell-cell adhesion mediated by cadherin
GO_0014807	Biological process	regulation of somitogenesis
GO_0010812	Biological process	negative regulation of cell-substrate adhesion
GO_0071228	Biological process	cellular response to tumor cell
GO_0090051	Biological process	negative regulation of cell migration involved in sprouting angiogenesis
GO_0030216	Biological process	keratinocyte differentiation
GO_0048715	Biological process	negative regulation of oligodendrocyte differentiation
GO_0003198	Biological process	epithelial to mesenchymal transition involved in endocardial cushion formation
GO_0072017	Biological process	distal tubule development
GO_0060045	Biological process	positive regulation of cardiac muscle cell proliferation
GO_0042670	Biological process	retinal cone cell differentiation
GO_0060411	Biological process	cardiac septum morphogenesis
GO_0017156	Biological process	calcium-ion regulated exocytosis
GO_0031069	Biological process	hair follicle morphogenesis
GO_0003181	Biological process	atrioventricular valve morphogenesis
GO_0003180	Biological process	aortic valve morphogenesis
GO_0001889	Biological process	liver development
GO_0003214	Biological process	cardiac left ventricle morphogenesis
GO_0042246	Biological process	tissue regeneration
GO_1901201	Biological process	regulation of extracellular matrix assembly
GO_0045070	Biological process	positive regulation of viral genome replication
GO_1902263	Biological process	apoptotic process involved in embryonic digit morphogenesis
GO_0003207	Biological process	cardiac chamber formation
GO_0002040	Biological process	sprouting angiogenesis
GO_0060038	Biological process	cardiac muscle cell proliferation
GO_0010832	Biological process	negative regulation of myotube differentiation
GO_0003209	Biological process	cardiac atrium morphogenesis
GO_0007492	Biological process	endoderm development
GO_1903849	Biological process	positive regulation of aorta morphogenesis
GO_0072148	Biological process	epithelial cell fate commitment
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0060253	Biological process	negative regulation of glial cell proliferation
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0060379	Biological process	cardiac muscle cell myoblast differentiation
GO_0045608	Biological process	negative regulation of inner ear auditory receptor cell differentiation
GO_0072044	Biological process	collecting duct development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0046427	Biological process	positive regulation of receptor signaling pathway via JAK-STAT
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0010614	Biological process	negative regulation of cardiac muscle hypertrophy
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0071456	Biological process	cellular response to hypoxia
GO_0120163	Biological process	negative regulation of cold-induced thermogenesis
GO_0097400	Biological process	interleukin-17-mediated signaling pathway
GO_0072144	Biological process	glomerular mesangial cell development
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0007283	Biological process	spermatogenesis
GO_0048754	Biological process	branching morphogenesis of an epithelial tube
GO_0007507	Biological process	heart development
GO_0045603	Biological process	positive regulation of endothelial cell differentiation
GO_0007440	Biological process	foregut morphogenesis
GO_0050768	Biological process	negative regulation of neurogenesis
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0050680	Biological process	negative regulation of epithelial cell proliferation
GO_0035116	Biological process	embryonic hindlimb morphogenesis
GO_0060956	Biological process	endocardial cell differentiation
GO_0060317	Biological process	cardiac epithelial to mesenchymal transition
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0043086	Biological process	negative regulation of catalytic activity
GO_0060768	Biological process	regulation of epithelial cell proliferation involved in prostate gland development
GO_0046533	Biological process	negative regulation of photoreceptor cell differentiation
GO_0007221	Biological process	positive regulation of transcription of Notch receptor target
GO_0014031	Biological process	mesenchymal cell development
GO_0003270	Biological process	Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO_0072091	Biological process	regulation of stem cell proliferation
GO_0030335	Biological process	positive regulation of cell migration
GO_0060948	Biological process	cardiac vascular smooth muscle cell development
GO_2000737	Biological process	negative regulation of stem cell differentiation
GO_0003213	Biological process	cardiac right atrium morphogenesis
GO_0048709	Biological process	oligodendrocyte differentiation
GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0003162	Biological process	atrioventricular node development
GO_0003222	Biological process	ventricular trabecula myocardium morphogenesis
GO_0021915	Biological process	neural tube development
GO_0003160	Biological process	endocardium morphogenesis
GO_0032496	Biological process	response to lipopolysaccharide
GO_0007411	Biological process	axon guidance
GO_0003182	Biological process	coronary sinus valve morphogenesis
GO_0001669	Cellular component	acrosomal vesicle
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0009986	Cellular component	cell surface
GO_0010008	Cellular component	endosome membrane
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0005654	Cellular component	nucleoplasm
GO_0005912	Cellular component	adherens junction
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0000139	Cellular component	Golgi membrane
GO_0002193	Cellular component	MAML1-RBP-Jkappa- ICN1 complex
GO_0016324	Cellular component	apical plasma membrane
GO_0005829	Cellular component	cytosol
GO_0004857	Molecular function	enzyme inhibitor activity
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0005112	Molecular function	Notch binding
GO_0042802	Molecular function	identical protein binding
GO_0031490	Molecular function	chromatin DNA binding
GO_0005509	Molecular function	calcium ion binding
GO_0140537	Molecular function	transcription regulator activator activity
GO_0019899	Molecular function	enzyme binding
GO_0000987	Molecular function	cis-regulatory region sequence-specific DNA binding
GO_0005515	Molecular function	protein binding
GO_0003713	Molecular function	transcription coactivator activity

Gene name	NOTCH1
Protein name	Notch receptor 1 Alternative protein NOTCH1 Notch 1 Mutant notch 1 Neurogenic locus notch homolog protein 1 Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] NOTCH1 variant NOTCH1 protein Truncated NOTCH1
Synonyms	TAN1
Description	FUNCTION: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). .
Accessions	A0A7P0T8W1 L8EAX5 H6VYP0 H9CXX2 A0A7P0TAK8 ENST00000680924.1 H9BDU9 A0A7P0Z4H9 A0A7P0TBG2 ENST00000680778.1 ENST00000680133.1 ENST00000651671.1 ENST00000681454.1 ENST00000679595.1 A0A7P0T8U6 P46531 ENST00000680218.1 W6FHB5 A7TW83 A0A7P0TA56 ENST00000681135.1 A0A7P0T9V1 A0A7P0TB20 Q6IAD4 H6VYP1 ENST00000680668.1

NOTCH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review