NKD1 report

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	8 studies	27% ± 13%	Explore
smooth muscle cell	7 studies	29% ± 10%	Explore
endothelial cell	6 studies	33% ± 13%	Explore
fibroblast	6 studies	23% ± 5%	Explore
myofibroblast cell	3 studies	39% ± 12%	Explore
oligodendrocyte	3 studies	18% ± 2%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NKD1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	1799.24	2539 / 2642	96%	25.62	674 / 705
intestine	87%	2819.19	839 / 966	72%	20.11	381 / 527
prostate	93%	2461.21	227 / 245	61%	3.42	307 / 502
esophagus	93%	5870.87	1348 / 1445	44%	5.72	81 / 183
ovary	98%	2486.21	177 / 180	39%	1.83	167 / 430
stomach	69%	1481.20	249 / 359	62%	20.85	177 / 286
lung	98%	6410.35	569 / 578	29%	3.38	332 / 1155
uterus	99%	3681.09	168 / 170	23%	3.24	104 / 459
bladder	86%	1918.38	18 / 21	31%	6.80	156 / 504
pancreas	38%	358.37	124 / 328	67%	3.87	119 / 178
blood vessel	99%	8909.02	1327 / 1335	0%	0	0 / 0
skin	60%	1094.08	1079 / 1809	30%	2.13	140 / 472
spleen	81%	1267.14	196 / 241	0%	0	0 / 0
kidney	74%	1134.87	66 / 89	2%	0.09	21 / 901
adipose	71%	1353.59	855 / 1204	0%	0	0 / 0
breast	52%	812.86	238 / 459	18%	0.59	196 / 1118
adrenal gland	33%	336.90	85 / 258	28%	5.41	65 / 230
eye	0%	0	0 / 0	31%	1.21	25 / 80
liver	4%	35.80	10 / 226	24%	6.73	96 / 406
thymus	11%	154.01	72 / 653	2%	0.18	10 / 605
tonsil	0%	0	0 / 0	9%	0.47	4 / 45
heart	6%	60.57	53 / 861	0%	0	0 / 0
muscle	2%	27.54	19 / 803	0%	0	0 / 0
peripheral blood	2%	19.33	19 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0060026	Biological process	convergent extension
GO_0030178	Biological process	negative regulation of Wnt signaling pathway
GO_0045732	Biological process	positive regulation of protein catabolic process
GO_0001754	Biological process	eye photoreceptor cell differentiation
GO_0007525	Biological process	somatic muscle development
GO_0016055	Biological process	Wnt signaling pathway
GO_0090249	Biological process	regulation of cell migration involved in somitogenic axis elongation
GO_0003401	Biological process	axis elongation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_2000052	Biological process	positive regulation of non-canonical Wnt signaling pathway
GO_2000096	Biological process	positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0000159	Cellular component	protein phosphatase type 2A complex
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0030165	Molecular function	PDZ domain binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

Gene name	NKD1
Protein name	Protein naked cuticle homolog 1 (Naked-1) (hNkd) (hNkd1)
Synonyms	PP7246 NKD
Description	FUNCTION: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. .
Accessions	Q969G9 ENST00000268459.6