TLE5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	51% ± 20%	Explore
endothelial cell	37 studies	35% ± 15%	Explore
B cell	35 studies	38% ± 18%	Explore
CD8-positive, alpha-beta T cell	34 studies	46% ± 21%	Explore
T cell	32 studies	45% ± 18%	Explore
CD4-positive, alpha-beta T cell	31 studies	51% ± 21%	Explore
fibroblast	30 studies	34% ± 14%	Explore
pericyte	24 studies	37% ± 13%	Explore
regulatory T cell	24 studies	51% ± 18%	Explore
macrophage	20 studies	24% ± 9%	Explore
basal cell	20 studies	42% ± 20%	Explore
smooth muscle cell	19 studies	33% ± 14%	Explore
mature NK T cell	19 studies	49% ± 17%	Explore
epithelial cell	19 studies	38% ± 18%	Explore
naive B cell	18 studies	42% ± 17%	Explore
conventional dendritic cell	17 studies	29% ± 21%	Explore
memory B cell	17 studies	38% ± 18%	Explore
ciliated cell	17 studies	54% ± 14%	Explore
classical monocyte	17 studies	30% ± 20%	Explore
gamma-delta T cell	16 studies	52% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	63% ± 21%	Explore
plasmacytoid dendritic cell	15 studies	41% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	51% ± 22%	Explore
mucosal invariant T cell	14 studies	46% ± 16%	Explore
capillary endothelial cell	14 studies	34% ± 10%	Explore
myofibroblast cell	14 studies	32% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	66% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	68% ± 15%	Explore
connective tissue cell	12 studies	33% ± 9%	Explore
glutamatergic neuron	12 studies	31% ± 16%	Explore
endothelial cell of artery	12 studies	45% ± 14%	Explore
endothelial cell of lymphatic vessel	11 studies	27% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	55% ± 29%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	55% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	52% ± 20%	Explore
secretory cell	11 studies	40% ± 13%	Explore
vein endothelial cell	10 studies	30% ± 12%	Explore
monocyte	9 studies	23% ± 7%	Explore
type I pneumocyte	9 studies	36% ± 14%	Explore
club cell	9 studies	40% ± 18%	Explore
dendritic cell	8 studies	45% ± 26%	Explore
goblet cell	8 studies	33% ± 16%	Explore
alveolar macrophage	7 studies	22% ± 5%	Explore
type II pneumocyte	7 studies	27% ± 13%	Explore
innate lymphoid cell	7 studies	42% ± 22%	Explore
plasma cell	7 studies	31% ± 13%	Explore
respiratory goblet cell	7 studies	45% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	45% ± 14%	Explore
leukocyte	7 studies	36% ± 11%	Explore
non-classical monocyte	7 studies	31% ± 18%	Explore
abnormal cell	7 studies	32% ± 18%	Explore
neuron	7 studies	41% ± 18%	Explore
GABAergic neuron	7 studies	36% ± 16%	Explore
myeloid cell	7 studies	33% ± 20%	Explore
endothelial cell of vascular tree	7 studies	27% ± 10%	Explore
plasmablast	6 studies	49% ± 23%	Explore
ionocyte	6 studies	51% ± 15%	Explore
platelet	6 studies	26% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	52% ± 15%	Explore
precursor B cell	6 studies	62% ± 14%	Explore
T follicular helper cell	6 studies	34% ± 14%	Explore
interneuron	6 studies	31% ± 18%	Explore
CD4-positive helper T cell	5 studies	47% ± 17%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	62% ± 21%	Explore
hematopoietic precursor cell	5 studies	48% ± 27%	Explore
exhausted T cell	5 studies	53% ± 26%	Explore
enteroendocrine cell	5 studies	45% ± 19%	Explore
mesothelial cell	5 studies	33% ± 15%	Explore
transit amplifying cell	5 studies	26% ± 10%	Explore
lymphocyte	5 studies	34% ± 17%	Explore
pro-B cell	5 studies	53% ± 21%	Explore
T-helper 17 cell	5 studies	48% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	72% ± 19%	Explore
oligodendrocyte precursor cell	5 studies	30% ± 13%	Explore
oligodendrocyte	5 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	41% ± 10%	Explore
deuterosomal cell	4 studies	34% ± 12%	Explore
squamous epithelial cell	4 studies	52% ± 17%	Explore
mononuclear phagocyte	4 studies	24% ± 9%	Explore
glomerular endothelial cell	4 studies	40% ± 9%	Explore
kidney loop of Henle epithelial cell	4 studies	29% ± 9%	Explore
retinal ganglion cell	4 studies	71% ± 19%	Explore
brush cell	4 studies	41% ± 23%	Explore
immature B cell	4 studies	65% ± 20%	Explore
progenitor cell	4 studies	29% ± 8%	Explore
amacrine cell	4 studies	36% ± 14%	Explore
astrocyte	4 studies	28% ± 9%	Explore
adventitial cell	4 studies	22% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 6%	Explore
luminal cell of prostate epithelium	4 studies	25% ± 7%	Explore
double negative thymocyte	4 studies	64% ± 17%	Explore
mast cell	3 studies	26% ± 3%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	42% ± 11%	Explore
duct epithelial cell	3 studies	53% ± 13%	Explore
hillock cell	3 studies	39% ± 10%	Explore
pancreatic A cell	3 studies	43% ± 3%	Explore
type B pancreatic cell	3 studies	46% ± 12%	Explore
retinal bipolar neuron	3 studies	44% ± 11%	Explore
thymocyte	3 studies	30% ± 5%	Explore
extravillous trophoblast	3 studies	71% ± 2%	Explore
hematopoietic stem cell	3 studies	41% ± 27%	Explore
retinal cone cell	3 studies	42% ± 7%	Explore
mucus secreting cell	3 studies	25% ± 7%	Explore
serous secreting cell	3 studies	34% ± 9%	Explore
rod bipolar cell	3 studies	42% ± 21%	Explore
erythroblast	3 studies	47% ± 30%	Explore
germinal center B cell	3 studies	24% ± 1%	Explore
muscle cell	3 studies	35% ± 15%	Explore
granulocyte	3 studies	29% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	52% ± 15%	Explore
double-positive, alpha-beta thymocyte	3 studies	66% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	39% ± 16%	Explore
peripheral blood	17 studies	52% ± 16%	Explore
brain	14 studies	28% ± 12%	Explore
intestine	10 studies	29% ± 13%	Explore
eye	8 studies	27% ± 11%	Explore
kidney	6 studies	29% ± 7%	Explore
lymph node	6 studies	35% ± 14%	Explore
bone marrow	5 studies	40% ± 26%	Explore
liver	5 studies	33% ± 12%	Explore
uterus	4 studies	40% ± 13%	Explore
breast	4 studies	27% ± 11%	Explore
pancreas	3 studies	39% ± 12%	Explore
placenta	3 studies	34% ± 22%	Explore
prostate	3 studies	27% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	22246.22	258 / 258	100%	209.24	230 / 230
ovary	100%	15862.16	180 / 180	100%	110.28	430 / 430
pancreas	100%	9114.02	328 / 328	100%	133.59	178 / 178
thymus	100%	21002.08	653 / 653	100%	215.62	605 / 605
brain	100%	22883.53	2639 / 2642	100%	114.11	705 / 705
uterus	100%	21040.54	170 / 170	100%	126.25	458 / 459
intestine	100%	19939.44	966 / 966	100%	127.30	525 / 527
prostate	100%	19454.56	245 / 245	100%	161.09	500 / 502
esophagus	100%	19134.69	1445 / 1445	99%	85.91	182 / 183
kidney	100%	15241.11	89 / 89	99%	113.90	896 / 901
breast	100%	13788.73	459 / 459	99%	121.15	1109 / 1118
lung	100%	17134.92	577 / 578	99%	101.25	1147 / 1155
skin	100%	12040.05	1808 / 1809	99%	102.65	467 / 472
stomach	100%	13152.20	359 / 359	99%	111.28	282 / 286
bladder	100%	20148.05	21 / 21	98%	139.16	496 / 504
liver	100%	8025.83	226 / 226	96%	66.23	391 / 406
adipose	100%	13900.37	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	129.01	80 / 80
lymph node	0%	0	0 / 0	100%	135.03	29 / 29
muscle	100%	19849.81	803 / 803	0%	0	0 / 0
spleen	100%	19524.06	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	122.56	45 / 45
ureter	0%	0	0 / 0	100%	155.78	1 / 1
blood vessel	100%	12448.57	1333 / 1335	0%	0	0 / 0
heart	100%	21382.89	859 / 861	0%	0	0 / 0
peripheral blood	97%	11898.57	899 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001501	Biological process	skeletal system development
GO_0016055	Biological process	Wnt signaling pathway
GO_0032091	Biological process	negative regulation of protein binding
GO_2000210	Biological process	positive regulation of anoikis
GO_0070555	Biological process	response to interleukin-1
GO_0010629	Biological process	negative regulation of gene expression
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0040008	Biological process	regulation of growth
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0060761	Biological process	negative regulation of response to cytokine stimulus
GO_0005634	Cellular component	nucleus
GO_0003714	Molecular function	transcription corepressor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TLE5
Protein name	Amino-terminal enhancer of split, isoform CRA_a (TLE family member 5, transcriptional modulator) TLE family member 5, transcriptional modulator TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Synonyms	GRG hCG_2005178 AES GRG5
Description	FUNCTION: Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. .
Accessions	ENST00000586742.5 ENST00000327141.9 [Q08117-1] K7ELQ8 K7ELE3 ENST00000221561.12 [Q08117-2] ENST00000586839.1 ENST00000585557.1 K7EQH5 Q08117

TLE5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review