LRP4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0030279Biological processnegative regulation of ossification
GO_0071340Biological processskeletal muscle acetylcholine-gated channel clustering
GO_0009954Biological processproximal/distal pattern formation
GO_0097104Biological processpostsynaptic membrane assembly
GO_0006897Biological processendocytosis
GO_0048813Biological processdendrite morphogenesis
GO_0050771Biological processnegative regulation of axonogenesis
GO_0007167Biological processenzyme-linked receptor protein signaling pathway
GO_0060173Biological processlimb development
GO_0042733Biological processembryonic digit morphogenesis
GO_0001822Biological processkidney development
GO_0035022Biological processpositive regulation of Rac protein signal transduction
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0009953Biological processdorsal/ventral pattern formation
GO_0051124Biological processsynaptic assembly at neuromuscular junction
GO_0048699Biological processgeneration of neurons
GO_1901631Biological processpositive regulation of presynaptic membrane organization
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0150094Biological processamyloid-beta clearance by cellular catabolic process
GO_0001942Biological processhair follicle development
GO_1904395Biological processpositive regulation of skeletal muscle acetylcholine-gated channel clustering
GO_0016055Biological processWnt signaling pathway
GO_0050808Biological processsynapse organization
GO_0097105Biological processpresynaptic membrane assembly
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0097060Cellular componentsynaptic membrane
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0044853Cellular componentplasma membrane raft
GO_0014069Cellular componentpostsynaptic density
GO_0015026Molecular functioncoreceptor activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0034185Molecular functionapolipoprotein binding
GO_0097110Molecular functionscaffold protein binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameLRP4
Protein nameLDL receptor related protein 4
Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)
SynonymsMEGF7
LRP10
KIAA0816
DescriptionFUNCTION: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity). .

AccessionsO75096
ENST00000534404.1
E9PNJ5
ENST00000378623.6