I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 20 studies | 46% ± 19% | |
| connective tissue cell | 9 studies | 36% ± 23% | |
| adventitial cell | 5 studies | 59% ± 21% | |
| mesothelial cell | 3 studies | 34% ± 18% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 20 studies | 46% ± 19% | |
| connective tissue cell | 9 studies | 36% ± 23% | |
| adventitial cell | 5 studies | 59% ± 21% | |
| mesothelial cell | 3 studies | 34% ± 18% |
Insufficient scRNA-seq data for expression of SFRP2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 90% | 13834.05 | 412 / 459 | 93% | 930.84 | 1036 / 1118 |
| bladder | 95% | 9025.00 | 20 / 21 | 41% | 179.49 | 209 / 504 |
| esophagus | 89% | 7014.28 | 1280 / 1445 | 48% | 175.79 | 88 / 183 |
| lung | 65% | 5522.42 | 374 / 578 | 71% | 283.35 | 821 / 1155 |
| pancreas | 34% | 1328.72 | 112 / 328 | 89% | 1151.36 | 159 / 178 |
| thymus | 85% | 9209.28 | 557 / 653 | 35% | 169.30 | 214 / 605 |
| prostate | 80% | 5505.88 | 195 / 245 | 33% | 52.18 | 166 / 502 |
| intestine | 75% | 6046.70 | 724 / 966 | 32% | 143.23 | 170 / 527 |
| blood vessel | 91% | 18210.33 | 1217 / 1335 | 0% | 0 | 0 / 0 |
| stomach | 44% | 2569.54 | 157 / 359 | 43% | 169.61 | 122 / 286 |
| skin | 60% | 5140.99 | 1078 / 1809 | 26% | 66.01 | 123 / 472 |
| adipose | 72% | 8227.78 | 872 / 1204 | 0% | 0 | 0 / 0 |
| uterus | 22% | 1043.89 | 38 / 170 | 38% | 153.96 | 173 / 459 |
| brain | 4% | 111.62 | 118 / 2642 | 41% | 151.91 | 290 / 705 |
| ovary | 9% | 682.81 | 17 / 180 | 34% | 122.06 | 145 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 104.78 | 13 / 45 |
| kidney | 7% | 275.04 | 6 / 89 | 18% | 54.01 | 159 / 901 |
| adrenal gland | 9% | 211.80 | 24 / 258 | 2% | 4.24 | 5 / 230 |
| muscle | 6% | 208.75 | 48 / 803 | 0% | 0 | 0 / 0 |
| heart | 4% | 141.21 | 38 / 861 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 2% | 6.73 | 10 / 406 |
| peripheral blood | 0% | 2.92 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042662 | Biological process | negative regulation of mesodermal cell fate specification |
| GO_0007584 | Biological process | response to nutrient |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0061056 | Biological process | sclerotome development |
| GO_0003151 | Biological process | outflow tract morphogenesis |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0010629 | Biological process | negative regulation of gene expression |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0003402 | Biological process | planar cell polarity pathway involved in axis elongation |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0060028 | Biological process | convergent extension involved in axis elongation |
| GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
| GO_0042733 | Biological process | embryonic digit morphogenesis |
| GO_1904956 | Biological process | regulation of midbrain dopaminergic neuron differentiation |
| GO_2000041 | Biological process | negative regulation of planar cell polarity pathway involved in axis elongation |
| GO_0003214 | Biological process | cardiac left ventricle morphogenesis |
| GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
| GO_0090090 | Biological process | negative regulation of canonical Wnt signaling pathway |
| GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
| GO_0048866 | Biological process | stem cell fate specification |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0060070 | Biological process | canonical Wnt signaling pathway |
| GO_0002063 | Biological process | chondrocyte development |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0071425 | Biological process | hematopoietic stem cell proliferation |
| GO_0090179 | Biological process | planar cell polarity pathway involved in neural tube closure |
| GO_0050732 | Biological process | negative regulation of peptidyl-tyrosine phosphorylation |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0030178 | Biological process | negative regulation of Wnt signaling pathway |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
| GO_0071481 | Biological process | cellular response to X-ray |
| GO_0036342 | Biological process | post-anal tail morphogenesis |
| GO_2000035 | Biological process | regulation of stem cell division |
| GO_0045600 | Biological process | positive regulation of fat cell differentiation |
| GO_1902230 | Biological process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| GO_0010659 | Biological process | cardiac muscle cell apoptotic process |
| GO_0008584 | Biological process | male gonad development |
| GO_0010975 | Biological process | regulation of neuron projection development |
| GO_1902042 | Biological process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0007501 | Biological process | mesodermal cell fate specification |
| GO_0030199 | Biological process | collagen fibril organization |
| GO_0090244 | Biological process | Wnt signaling pathway involved in somitogenesis |
| GO_0035567 | Biological process | non-canonical Wnt signaling pathway |
| GO_0010667 | Biological process | negative regulation of cardiac muscle cell apoptotic process |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0061185 | Biological process | negative regulation of dermatome development |
| GO_0048546 | Biological process | digestive tract morphogenesis |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0005615 | Cellular component | extracellular space |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0017147 | Molecular function | Wnt-protein binding |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0061133 | Molecular function | endopeptidase activator activity |
| GO_0001968 | Molecular function | fibronectin binding |
| GO_0005178 | Molecular function | integrin binding |
| Gene name | SFRP2 |
| Protein name | Secreted frizzled-related protein 2 (FRP-2) (sFRP-2) (Secreted apoptosis-related protein 1) (SARP-1) |
| Synonyms | FKSG12 SARP1 UNQ361/PRO697 FRP2 |
| Description | FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. |
| Accessions | Q96HF1 ENST00000274063.5 |
