TLE1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0010628Biological processpositive regulation of gene expression
GO_0016055Biological processWnt signaling pathway
GO_2000811Biological processnegative regulation of anoikis
GO_0009887Biological processanimal organ morphogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_1990907Cellular componentbeta-catenin-TCF complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTLE1
Protein nameTLE family member 1, transcriptional corepressor
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Synonyms
DescriptionFUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. .

AccessionsENST00000674113.1
Q5T3G3
A0A669KBB1
ENST00000418319.5
ENST00000464999.1
Q5T3G2
ENST00000491534.5
ENST00000376484.2
ENST00000376463.3
ENST00000376499.8
A0A669KAE5
F6T2C8
A0A669KBK8
Q04724