UBAC2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	21 studies	28% ± 10%	Explore
T cell	19 studies	23% ± 8%	Explore
macrophage	19 studies	31% ± 17%	Explore
CD4-positive, alpha-beta T cell	19 studies	23% ± 5%	Explore
CD8-positive, alpha-beta T cell	19 studies	22% ± 6%	Explore
natural killer cell	17 studies	23% ± 6%	Explore
B cell	16 studies	24% ± 9%	Explore
regulatory T cell	13 studies	19% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	24% ± 6%	Explore
gamma-delta T cell	12 studies	24% ± 6%	Explore
astrocyte	12 studies	35% ± 17%	Explore
fibroblast	12 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	24% ± 4%	Explore
microglial cell	11 studies	45% ± 12%	Explore
naive B cell	11 studies	22% ± 3%	Explore
glutamatergic neuron	10 studies	43% ± 26%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	24% ± 6%	Explore
oligodendrocyte precursor cell	10 studies	29% ± 12%	Explore
mucosal invariant T cell	10 studies	26% ± 5%	Explore
epithelial cell	10 studies	34% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	20% ± 5%	Explore
myeloid cell	9 studies	32% ± 10%	Explore
ciliated cell	9 studies	26% ± 9%	Explore
adipocyte	9 studies	26% ± 6%	Explore
oligodendrocyte	9 studies	26% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	26% ± 4%	Explore
mature NK T cell	8 studies	23% ± 8%	Explore
GABAergic neuron	8 studies	44% ± 23%	Explore
plasmacytoid dendritic cell	8 studies	28% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	23% ± 4%	Explore
classical monocyte	7 studies	22% ± 6%	Explore
dendritic cell	7 studies	37% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	21% ± 5%	Explore
neuron	6 studies	35% ± 15%	Explore
interneuron	6 studies	43% ± 24%	Explore
myofibroblast cell	6 studies	20% ± 7%	Explore
pericyte	6 studies	24% ± 9%	Explore
smooth muscle cell	6 studies	20% ± 4%	Explore
T follicular helper cell	6 studies	20% ± 4%	Explore
type II pneumocyte	6 studies	24% ± 7%	Explore
monocyte	6 studies	33% ± 11%	Explore
connective tissue cell	5 studies	20% ± 4%	Explore
cardiac muscle cell	5 studies	35% ± 9%	Explore
mononuclear phagocyte	5 studies	25% ± 7%	Explore
memory B cell	5 studies	17% ± 1%	Explore
endothelial cell of lymphatic vessel	5 studies	30% ± 9%	Explore
type I pneumocyte	5 studies	23% ± 8%	Explore
platelet	5 studies	26% ± 6%	Explore
leukocyte	5 studies	40% ± 18%	Explore
club cell	5 studies	26% ± 10%	Explore
basal cell	5 studies	44% ± 20%	Explore
hematopoietic precursor cell	4 studies	25% ± 9%	Explore
conventional dendritic cell	4 studies	35% ± 14%	Explore
non-classical monocyte	4 studies	26% ± 3%	Explore
granule cell	4 studies	26% ± 6%	Explore
precursor B cell	4 studies	23% ± 4%	Explore
immature B cell	4 studies	24% ± 4%	Explore
mast cell	4 studies	22% ± 6%	Explore
lymphocyte	4 studies	45% ± 16%	Explore
amacrine cell	4 studies	20% ± 5%	Explore
abnormal cell	4 studies	27% ± 14%	Explore
innate lymphoid cell	4 studies	21% ± 2%	Explore
respiratory goblet cell	4 studies	32% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 6%	Explore
renal principal cell	4 studies	24% ± 7%	Explore
GABAergic interneuron	3 studies	28% ± 3%	Explore
Mueller cell	3 studies	21% ± 4%	Explore
glycinergic amacrine cell	3 studies	20% ± 3%	Explore
retinal rod cell	3 studies	18% ± 0%	Explore
hepatocyte	3 studies	50% ± 15%	Explore
muscle cell	3 studies	28% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
neural progenitor cell	3 studies	20% ± 5%	Explore
ependymal cell	3 studies	32% ± 23%	Explore
hematopoietic stem cell	3 studies	24% ± 3%	Explore
alveolar macrophage	3 studies	35% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 6%	Explore
goblet cell	3 studies	38% ± 25%	Explore
transit amplifying cell	3 studies	41% ± 33%	Explore
double negative thymocyte	3 studies	26% ± 8%	Explore
mucus secreting cell	3 studies	32% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	34% ± 20%	Explore
peripheral blood	11 studies	21% ± 5%	Explore
lung	10 studies	23% ± 8%	Explore
liver	5 studies	29% ± 12%	Explore
heart	4 studies	26% ± 5%	Explore
eye	4 studies	28% ± 16%	Explore
kidney	4 studies	20% ± 3%	Explore
adipose	4 studies	24% ± 5%	Explore
lymph node	3 studies	19% ± 3%	Explore
intestine	3 studies	23% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3331.74	459 / 459	100%	61.41	1118 / 1118
esophagus	100%	3674.47	1445 / 1445	100%	42.97	183 / 183
liver	100%	2561.14	226 / 226	100%	45.36	406 / 406
ovary	100%	2783.84	180 / 180	100%	47.09	430 / 430
prostate	100%	3020.91	245 / 245	100%	55.81	502 / 502
stomach	100%	2473.18	359 / 359	100%	66.33	286 / 286
uterus	100%	2907.35	170 / 170	100%	64.46	459 / 459
kidney	100%	3001.28	89 / 89	100%	64.53	900 / 901
thymus	100%	3400.91	653 / 653	100%	61.94	604 / 605
lung	100%	2999.72	577 / 578	100%	53.99	1155 / 1155
intestine	100%	3019.49	966 / 966	100%	79.12	526 / 527
bladder	100%	2591.71	21 / 21	100%	73.96	503 / 504
brain	100%	1977.94	2635 / 2642	100%	43.57	705 / 705
pancreas	100%	1652.91	327 / 328	100%	58.56	178 / 178
skin	100%	4943.34	1809 / 1809	100%	54.46	470 / 472
adrenal gland	100%	2708.82	258 / 258	96%	25.25	221 / 230
adipose	100%	3109.57	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	54.40	80 / 80
lymph node	0%	0	0 / 0	100%	45.45	29 / 29
muscle	100%	3336.85	803 / 803	0%	0	0 / 0
spleen	100%	3293.66	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	49.89	45 / 45
ureter	0%	0	0 / 0	100%	22.39	1 / 1
blood vessel	100%	2687.89	1334 / 1335	0%	0	0 / 0
heart	99%	2143.37	854 / 861	0%	0	0 / 0
peripheral blood	98%	2157.16	915 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1904153	Biological process	negative regulation of retrograde protein transport, ER to cytosol
GO_0016055	Biological process	Wnt signaling pathway
GO_0090090	Biological process	negative regulation of canonical Wnt signaling pathway
GO_0070972	Biological process	protein localization to endoplasmic reticulum
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	UBAC2
Protein name	Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1) UBA domain containing 2
Synonyms	PHGDHL1 PSEC0110
Description	FUNCTION: Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets . In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 . .
Accessions	ENST00000474510.2 ENST00000403766.8 [Q8NBM4-1] Q5JUH4 A0A087WXT1 X6R5E5 ENST00000376440.6 [Q8NBM4-2] ENST00000355700.9 Q8NBM4 ENST00000457666.1

UBAC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review