MAD2L2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0001558Biological processregulation of cell growth
GO_0042276Biological processerror-prone translesion synthesis
GO_0006302Biological processdouble-strand break repair
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0051301Biological processcell division
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0090090Biological processnegative regulation of canonical Wnt signaling pathway
GO_1901203Biological processpositive regulation of extracellular matrix assembly
GO_2000678Biological processnegative regulation of transcription regulatory region DNA binding
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007015Biological processactin filament organization
GO_1904667Biological processnegative regulation of ubiquitin protein ligase activity
GO_0043247Biological processtelomere maintenance in response to DNA damage
GO_0042772Biological processDNA damage response, signal transduction resulting in transcription
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_2000048Biological processnegative regulation of cell-cell adhesion mediated by cadherin
GO_0002208Biological processsomatic diversification of immunoglobulins involved in immune response
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0045830Biological processpositive regulation of isotype switching
GO_0005680Cellular componentanaphase-promoting complex
GO_0005654Cellular componentnucleoplasm
GO_0016035Cellular componentzeta DNA polymerase complex
GO_0005737Cellular componentcytoplasm
GO_0005694Cellular componentchromosome
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0008432Molecular functionJUN kinase binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAD2L2
Protein nameMitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2)
Mitotic arrest deficient 2 like 2
Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7)
SynonymsREV7
MAD2B
DescriptionFUNCTION: Adapter protein able to interact with different proteins and involved in different biological processes . Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis . Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions . Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) . During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection . Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres . May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 . Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle . Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation . .

AccessionsENST00000456915.2
ENST00000376669.9
ENST00000376692.9
ENST00000235310.7
ENST00000697272.1
B1AK45
A0A8V8TL87
B1AK44
ENST00000456915.1
ENST00000445656.5
A0A8V8TMF5
ENST00000376672.5
Q9UI95
ENST00000376667.7
B1AK43
ENST00000697273.1
A0A8V8TKV6
ENST00000697274.1