GO_0035861 | OmnibusX

Name	site of double-strand break
ID	GO_0035861
collection_id	Cellular component
Exact synonym	site of DSB
Description	A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
Related synonym	DNA damage foci, DNA damage focus, IRIF, ionizing radiation-induced foci
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Genes	ATM WAS PARP1 POLH SMARCA5 SMC6 HUS1 PHF1 MRE11 ARPC2 INIP HELB PARP3 IFFO1 ZBTB7A SMARCAD1 SMCHD1 ASF1A RNF8 RNF168 RPA1 RPA2 SHLD1 WRAP53 ACTR3 PRPF19 NABP1 AIM2 NABP2 DYNLL1 H2AX PAXX ZGRF1 ATF2 STK38 NBN SLF2 LMNA RHNO1 RFWD3 MMS22L RPA3 HUS1B HTATSF1 SMARCAL1 POLQ ARPC3 PELI1 TP53 ARPC4 ARPC5 RIF1 UFL1 INTS3 RBBP8 UIMC1 EPC1 TOPBP1 RNF138 MDC1 MAD2L2 DDB1 DGCR8 CNTD1 RPA4 WDR70 RAD18 XRCC4 SIRT7 KAT5 ESCO2 SHLD3 SAMHD1 KDM4D VCP RAD17 NHEJ1 APLF POLL RAD50 TP53BP1 SMC5 CHD1L CYREN SHLD2 MBTD1 RNF169 PNKP SETMAR SIRT6 TIMELESS DMC1 RAD51 CGAS ARPC1A TONSL ACTR2 SLF1 shieldin_human

site of double-strand break