RPA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034502Biological processprotein localization to chromosome
GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_0006289Biological processnucleotide-excision repair
GO_0006260Biological processDNA replication
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0000723Biological processtelomere maintenance
GO_0031571Biological processmitotic G1 DNA damage checkpoint signaling
GO_2000001Biological processregulation of DNA damage checkpoint
GO_0006284Biological processbase-excision repair
GO_0006298Biological processmismatch repair
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0016605Cellular componentPML body
GO_0000781Cellular componentchromosome, telomeric region
GO_0005662Cellular componentDNA replication factor A complex
GO_0000785Cellular componentchromatin
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0098505Molecular functionG-rich strand telomeric DNA binding
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameRPA2
Protein nameReplication protein A2
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
SynonymsREPA2
RPA34
RPA32
DescriptionFUNCTION: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Also plays a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. .

AccessionsENST00000444045.1
ENST00000373909.7 [P15927-2]
ENST00000419958.5
ENST00000373912.8 [P15927-1]
ENST00000313433.11 [P15927-3]
P15927
Q5TEJ7
Q5TEJ0