MMS22L | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	4 studies	25% ± 7%	Explore
astrocyte	4 studies	31% ± 15%	Explore
oligodendrocyte	4 studies	28% ± 9%	Explore
hematopoietic precursor cell	3 studies	18% ± 2%	Explore
microglial cell	3 studies	18% ± 2%	Explore
epithelial cell	3 studies	22% ± 5%	Explore
macrophage	3 studies	17% ± 1%	Explore
transit amplifying cell	3 studies	45% ± 23%	Explore

Name	Number of supported studies	Average coverage
brain	5 studies	23% ± 7%	Explore
liver	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	353.17	1444 / 1445	99%	4.49	181 / 183
uterus	100%	458.80	170 / 170	95%	3.73	434 / 459
breast	100%	463.49	459 / 459	91%	2.81	1020 / 1118
stomach	99%	258.70	356 / 359	92%	2.86	263 / 286
intestine	100%	378.18	966 / 966	91%	2.60	477 / 527
lung	99%	366.53	573 / 578	88%	2.89	1022 / 1155
bladder	100%	343.90	21 / 21	85%	2.50	429 / 504
skin	100%	786.61	1808 / 1809	80%	2.10	377 / 472
brain	99%	295.60	2626 / 2642	77%	1.45	541 / 705
ovary	100%	406.49	180 / 180	75%	1.63	324 / 430
prostate	100%	354.10	245 / 245	58%	0.89	292 / 502
kidney	94%	224.51	84 / 89	60%	1.12	539 / 901
pancreas	98%	212.49	323 / 328	55%	0.96	98 / 178
thymus	100%	303.04	651 / 653	50%	0.87	304 / 605
adrenal gland	98%	339.14	253 / 258	46%	0.74	106 / 230
spleen	100%	454.78	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	4.49	45 / 45
adipose	100%	360.51	1202 / 1204	0%	0	0 / 0
blood vessel	99%	257.01	1324 / 1335	0%	0	0 / 0
heart	84%	139.85	721 / 861	0%	0	0 / 0
peripheral blood	78%	533.41	721 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	72%	1.82	21 / 29
liver	48%	67.22	109 / 226	22%	0.39	91 / 406
muscle	48%	54.68	387 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	19%	0.27	15 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0006325	Biological process	chromatin organization
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0031297	Biological process	replication fork processing
GO_0071168	Biological process	protein localization to chromatin
GO_0043596	Cellular component	nuclear replication fork
GO_0042555	Cellular component	MCM complex
GO_0090734	Cellular component	site of DNA damage
GO_0035101	Cellular component	FACT complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0003697	Molecular function	single-stranded DNA binding

Gene name	MMS22L
Protein name	Protein MMS22-like (Methyl methanesulfonate-sensitivity protein 22-like) MMS22 like, DNA repair protein
Synonyms	C6orf167
Description	FUNCTION: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks . The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication . It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs . Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination . Within the complex, MMS22L acts by binding ssDNA . .
Accessions	H0YAJ2 ENST00000509383.5 A0A2Z2E9D2 ENST00000510018.5 ENST00000275053.8 E2QRD4 Q6ZRQ5 ENST00000369251.6 ENST00000683635.1 H0Y8J1 H9KVD8 ENST00000482634.1

MMS22L report