RHNO1 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	4 studies	24% ± 8%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of RHNO1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	744.17	966 / 966	100%	37.11	527 / 527
ovary	100%	844.44	180 / 180	100%	52.24	430 / 430
prostate	100%	1050.23	245 / 245	100%	35.04	502 / 502
stomach	100%	553.95	359 / 359	100%	34.79	286 / 286
brain	100%	809.30	2639 / 2642	100%	40.15	705 / 705
esophagus	100%	795.03	1443 / 1445	100%	39.15	183 / 183
bladder	100%	750.67	21 / 21	100%	45.61	503 / 504
breast	100%	654.66	459 / 459	100%	48.88	1115 / 1118
thymus	100%	881.89	653 / 653	100%	46.39	603 / 605
skin	100%	1287.06	1809 / 1809	100%	39.97	470 / 472
uterus	99%	752.68	169 / 170	100%	54.67	459 / 459
kidney	100%	727.20	89 / 89	99%	27.17	893 / 901
lung	99%	588.03	571 / 578	100%	49.91	1155 / 1155
pancreas	100%	422.12	327 / 328	99%	31.97	176 / 178
adrenal gland	100%	736.12	258 / 258	98%	28.04	225 / 230
liver	63%	162.49	143 / 226	76%	13.89	307 / 406
lymph node	0%	0	0 / 0	100%	45.22	29 / 29
spleen	100%	910.42	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	56.07	45 / 45
ureter	0%	0	0 / 0	100%	35.35	1 / 1
adipose	100%	492.00	1200 / 1204	0%	0	0 / 0
blood vessel	100%	606.65	1330 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	96%	19.57	77 / 80
muscle	93%	339.08	745 / 803	0%	0	0 / 0
heart	86%	317.10	742 / 861	0%	0	0 / 0
peripheral blood	85%	793.16	790 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006325	Biological process	chromatin organization
GO_1990166	Biological process	protein localization to site of double-strand break
GO_0000725	Biological process	recombinational repair
GO_0097681	Biological process	double-strand break repair via alternative nonhomologous end joining
GO_0071479	Biological process	cellular response to ionizing radiation
GO_0034644	Biological process	cellular response to UV
GO_0000077	Biological process	DNA damage checkpoint signaling
GO_0070318	Biological process	positive regulation of G0 to G1 transition
GO_0005694	Cellular component	chromosome
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0035861	Cellular component	site of double-strand break
GO_0005634	Cellular component	nucleus
GO_0140463	Molecular function	chromatin-protein adaptor activity
GO_0005515	Molecular function	protein binding

Gene name	RHNO1
Protein name	RAD9-HUS1-RAD1 interacting nuclear orphan 1 RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein)
Synonyms	HKMT1188 C12orf32 RHINO
Description	FUNCTION: Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis . MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair double-strand breaks in DNA that originate in S-phase . Accumulates in M-phase; following phosphorylation by PLK1, interacts with POLQ, enabling its recruitment to double-strand breaks for subsequent repair . Also involved in the DNA damage response (DDR) signaling in response to genotoxic stresses such as ionizing radiation (IR) during the S phase . Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner . Required for the progression of the G1 to S phase transition . Plays a role in the stimulation of CHEK1 phosphorylation . .
Accessions	ENST00000535978.5 F5H7S2 ENST00000538636.5 ENST00000461997.5 [Q9BSD3-2] ENST00000618250.4 [Q9BSD3-1] Q9BSD3 F5H0U1 ENST00000366285.5 ENST00000489288.7 [Q9BSD3-1] ENST00000538700.2 F5H795 F5H580

RHNO1 report