RAD50 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	8 studies	26% ± 10%	Explore
oligodendrocyte precursor cell	8 studies	31% ± 14%	Explore
oligodendrocyte	8 studies	32% ± 11%	Explore
fibroblast	7 studies	22% ± 7%	Explore
type I pneumocyte	7 studies	20% ± 3%	Explore
glutamatergic neuron	7 studies	44% ± 25%	Explore
ciliated cell	7 studies	27% ± 10%	Explore
GABAergic neuron	6 studies	45% ± 20%	Explore
microglial cell	6 studies	24% ± 6%	Explore
astrocyte	6 studies	39% ± 12%	Explore
macrophage	5 studies	24% ± 5%	Explore
epithelial cell	5 studies	36% ± 19%	Explore
natural killer cell	4 studies	18% ± 2%	Explore
goblet cell	4 studies	20% ± 2%	Explore
basal cell	4 studies	22% ± 9%	Explore
interneuron	4 studies	50% ± 23%	Explore
B cell	3 studies	18% ± 2%	Explore
pancreatic A cell	3 studies	31% ± 15%	Explore
neuron	3 studies	35% ± 10%	Explore
GABAergic interneuron	3 studies	24% ± 2%	Explore
myeloid cell	3 studies	21% ± 6%	Explore
abnormal cell	3 studies	29% ± 12%	Explore
enteroendocrine cell	3 studies	18% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	35% ± 20%	Explore
pancreas	3 studies	33% ± 18%	Explore
intestine	3 studies	20% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	3015.49	359 / 359	63%	1.05	181 / 286
breast	100%	3354.91	459 / 459	53%	0.91	598 / 1118
esophagus	100%	3584.17	1445 / 1445	52%	0.80	96 / 183
intestine	100%	3863.79	966 / 966	47%	0.72	249 / 527
kidney	100%	2392.33	89 / 89	37%	0.59	335 / 901
brain	99%	2267.12	2616 / 2642	27%	0.37	192 / 705
bladder	100%	3712.48	21 / 21	25%	0.40	126 / 504
thymus	100%	3445.45	653 / 653	23%	0.30	142 / 605
lung	99%	2628.81	575 / 578	24%	0.38	276 / 1155
skin	100%	4219.91	1809 / 1809	23%	0.33	108 / 472
prostate	100%	3339.00	245 / 245	22%	0.31	111 / 502
pancreas	100%	2326.02	328 / 328	21%	0.30	38 / 178
adrenal gland	100%	3592.24	258 / 258	16%	0.20	36 / 230
ovary	100%	4354.62	180 / 180	13%	0.17	58 / 430
uterus	100%	3977.39	170 / 170	13%	0.20	61 / 459
liver	100%	1764.88	226 / 226	9%	0.12	36 / 406
adipose	100%	3074.22	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3219.86	1335 / 1335	0%	0	0 / 0
muscle	100%	2848.62	803 / 803	0%	0	0 / 0
spleen	100%	2539.13	241 / 241	0%	0	0 / 0
heart	93%	1990.20	802 / 861	0%	0	0 / 0
peripheral blood	43%	2061.01	403 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	31%	0.46	9 / 29
tonsil	0%	0	0 / 0	20%	0.25	9 / 45
eye	0%	0	0 / 0	6%	0.08	5 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032508	Biological process	DNA duplex unwinding
GO_0006281	Biological process	DNA repair
GO_0006302	Biological process	double-strand break repair
GO_0007131	Biological process	reciprocal meiotic recombination
GO_0006974	Biological process	DNA damage response
GO_0000722	Biological process	telomere maintenance via recombination
GO_0110025	Biological process	DNA strand resection involved in replication fork processing
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0033674	Biological process	positive regulation of kinase activity
GO_1904354	Biological process	negative regulation of telomere capping
GO_0000729	Biological process	DNA double-strand break processing
GO_0044818	Biological process	mitotic G2/M transition checkpoint
GO_0035825	Biological process	homologous recombination
GO_0032206	Biological process	positive regulation of telomere maintenance
GO_0062176	Biological process	R-loop processing
GO_0070192	Biological process	chromosome organization involved in meiotic cell cycle
GO_0000723	Biological process	telomere maintenance
GO_0031954	Biological process	positive regulation of protein autophosphorylation
GO_0006310	Biological process	DNA recombination
GO_0031860	Biological process	telomeric 3' overhang formation
GO_0000019	Biological process	regulation of mitotic recombination
GO_0007004	Biological process	telomere maintenance via telomerase
GO_0030870	Cellular component	Mre11 complex
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0070533	Cellular component	BRCA1-C complex
GO_0000794	Cellular component	condensed nuclear chromosome
GO_0000781	Cellular component	chromosome, telomeric region
GO_0035861	Cellular component	site of double-strand break
GO_0098687	Cellular component	chromosomal region
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0043047	Molecular function	single-stranded telomeric DNA binding
GO_0042802	Molecular function	identical protein binding
GO_0008408	Molecular function	3'-5' exonuclease activity
GO_0043539	Molecular function	protein serine/threonine kinase activator activity
GO_0051880	Molecular function	G-quadruplex DNA binding
GO_0003691	Molecular function	double-stranded telomeric DNA binding
GO_0003678	Molecular function	DNA helicase activity
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0000014	Molecular function	single-stranded DNA endodeoxyribonuclease activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	RAD50
Protein name	RAD50 protein RAD50 double strand break repair protein DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)
Synonyms
Description	FUNCTION: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point . The complex may also be required for DNA damage signaling via activation of the ATM kinase . In telomeres the MRN complex may modulate t-loop formation . .
Accessions	ENST00000453394.5 Q92878 A0A494C122 ENST00000652016.1 C9JNH8 E7ESD9 A0A494BZX5 ENST00000651723.1 ENST00000533482.5 ENST00000652485.1 A0A494BZX8 ENST00000651541.1 ENST00000455677.1 A0A494C1B7 E7EN38 Q32P42 H7C0V2 ENST00000434288.1 ENST00000651160.1 E9PM98 ENST00000416135.5 H7C0P8 A5D6Y3 ENST00000651249.1 A0A494C0Y7 A0A494BZW0 ENST00000423956.5 ENST00000378823.8 [Q92878-1]

RAD50 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review