DYNLL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0110027Biological processnegative regulation of DNA strand resection involved in replication fork processing
GO_0044458Biological processmotile cilium assembly
GO_0006974Biological processDNA damage response
GO_0035721Biological processintraciliary retrograde transport
GO_0045019Biological processnegative regulation of nitric oxide biosynthetic process
GO_0042326Biological processnegative regulation of phosphorylation
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0021762Biological processsubstantia nigra development
GO_0006915Biological processapoptotic process
GO_0007286Biological processspermatid development
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0072686Cellular componentmitotic spindle
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005868Cellular componentcytoplasmic dynein complex
GO_0097542Cellular componentciliary tip
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0070821Cellular componenttertiary granule membrane
GO_0008180Cellular componentCOP9 signalosome
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0005737Cellular componentcytoplasm
GO_0030286Cellular componentdynein complex
GO_1904115Cellular componentaxon cytoplasm
GO_0035861Cellular componentsite of double-strand break
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0097110Molecular functionscaffold protein binding
GO_0036487Molecular functionnitric-oxide synthase inhibitor activity
GO_0060703Molecular functiondeoxyribonuclease inhibitor activity
GO_0045505Molecular functiondynein intermediate chain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDYNLL1
Protein nameDynein light chain
Dynein light chain LC8-type 1
Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)
SynonymsDLC1
HDLC1
DNCLC1
DNCL1
hCG_27767
DescriptionFUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.; FUNCTION: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. .; FUNCTION: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. .; FUNCTION: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1. .

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. .; FUNCTION: Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1. .; FUNCTION: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. .; FUNCTION: Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity. .

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. .; FUNCTION: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. .

FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. .; FUNCTION: Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1. .

AccessionsENST00000392508.2
P63167
ENST00000392509.6
ENST00000550178.1
ENST00000548342.5
ENST00000549989.1
ENST00000548214.1
ENST00000550845.5
ENST00000552870.1
F8VXI7
F8VRV5
ENST00000549649.5
ENST00000242577.11
F8VXL2
Q6FGH9